Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 143 for “"synovial"”.
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Mixed and boundary lubrication in synovial joints
Human synovial joints have to withstand complex, varied and often harsh loading regimes. For approximately 90% of the time synovial joints and articular cartilage undergo very little motion, and these periods are commonly associated with significant amounts of prolonged loading. During these …
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Chondrogenic capacities of equine synovial progenitor populations
… research program is to provide strategies using synovial progenitor populations for articular cartilage repair in horses. The synovial fluid samples were added directly to culture medium and maintained until confluence. The primary cultures were passage twice to generate sufficient cell numbers …
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Osteochondral properties and relationships in the synovial joint
The overall goal of this study was to examine the relationship between the properties of articular cartilage and its underlying subchondral bone using an equine model. Thus, the objectives of this study were: (1) to determine the structural and mechanical properties of equine cartilage, (2) to …
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Synovial sarcoma : translating gene expression into patient care
Synovial sarcoma is a soft tissue tumor defined by the presence of t(X;18)(p11.2;q11.2), fusing the SYT (SS18) gene on chromosome 18 and one of three SSX genes on chromosome X. T(X;18) results in production of a fusion protein (SYT-SSX) that is thought to underlie synovial sarcoma pathogenesis …
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Investigating Synovial Fluid Electrochemical Properties Against Orthopaedic Alloys
… corrosion processes that occur at the CoCrMo-synovial fluid interface. The first study investigates the electrochemical behavior of CoCrMo in human synovial fluid obtained at the time of primary TKA, using CoCrMo in phosphate-buffered saline (PBS) as a comparison. The second study compares the …
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Hyporesponsive synovial fluid T cells in rheumatoid Arthritis
… role in pathogenesis. Both chronically inflamed synovial tissue and synovial fluid (SF) are usually rich in infiltrated CD4+ T helper cells (TH cells) and CD8+ cytotoxic T cells (CTL). Only T cells isolated from the SF of many RA patients were anergic upon their activation in vitro by stimulation …
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Joint contact modelling of articular cartilage in synovial joints
Hip joint is one of the important load bearing joints and has been extensively studied to investigate contact mechanics and tribology. It has known to experience high contact forces and stresses. However, cartilage shows remarkable lubricating and wear properties, and survives the lifetime of a …
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DAMPening synovial activation in osteoarthritis: taking the S100-road
Contains fulltext : 132082.pdf (Publisher’s version ) (Open Access)
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Mechanisms of Impaired Efferocytosis of Synovial Macrophages in Knee Osteoarthritis
… primary blood monocytes, which were treated with synovial fluid from patients with high levels of inflammation due to knee OA. By feeding labeled apoptotic cells to macrophages stimulated with synovial fluid and fixing the cells during the process of efferocytosis, we were able to identify the …
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Mechanisms of synovial fluid lipid-mediated neuronal sensitisation in arthritis
… targets is to use human samples, such as synovial fluid (SF), in pre-clinical research. SF lubricates healthy synovial joints, like the knee, and has been shown to have elevated levels of various inflammatory mediators, such as peptide nerve growth factor (NGF), which correlates with pain …
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Elucidating the Relationship Between Macrophages and Synovial Mesenchymal Progenitor Cell Chondrogenesis
… remains unknown is how macrophages interact with synovial mesenchymal progenitor cells (sMPCs) in the joint. sMPCs are able to differentiate into cartilage but for unknown reasons, sMPC chondrogenic capacity is lost in OA. This thesis elucidates the relationship between macrophages and sMPC using …
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Molecular and functional analyses of human synovial B-lymphocytes in rheumatoid arthritis
B-cells of the rheumatoid synovial tissue are a constant part of and, in some histopathological subtypes, the dominant population of the inflammatory infiltrate, located in the region of tissue destruction. The pattern of B-cell distribution and the relationship to the corresponding …
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The Effects of Synovial Fluid and Inflammatory Cells on Orthopaedic Implant Alloys
… and inflammation can alter the composition of Synovial Fluid (SF), potentially causing implant corrosion and the release of metal ions into the surrounding tissue. These metal ions can trigger innate and adaptive responses, further enhancing implant corrosion. As the number of primary TKA …
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Therapeutic Potential of TRP Channels in the Targeting of Rheumatoid Arthritis Synovial Fibroblasts
… cartilage and acts as a barrier which secretes synovial fluid that lubricates the joint. Synovial fibroblasts, also called fibroblast-like synoviocytes, are responsible for this secretion of lubricating components hyaluronic acid and lubricin that allow for ease of movement. Together with …
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VALIDATION OF CANDIDATE GENES IN RESPONSE TO VERSICAN MANIPULATION IN DEVELOPING SYNOVIAL JOINTS
Little is understood about the complex process of synovial joint formation in early limb development. It has been shown that versican is highly expressed in the extracellular matrix of these joints (Snow et al., 2005; Shepard et al., 2007) and the knockdown of versican leads to malformation of the …
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DEFINING THE ROLE OF THE PCGF3-CONTAINING POLYCOMB REPRESSIVE COMPLEX 1 IN SYNOVIAL SARCOMA
Synovial Sarcoma (SS) poses significant challenges in diagnosis and treatment due to its rarity and therapeutic options. The fusion protein SS18-SSX, found in over 95% of cases, is considered the primary oncogenic driver, disrupting BAF complexes and redirecting them to Polycomb repressive domains, …
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Synovial Fibrosis in Osteoarthritis of the Knee: Mechanism of Development and Potential Therapeutic Targets
<p>Synovial tissue fibrosis is an immune mediated disease characterized by fibroblast cell migration, proliferation and transition to a myofibroblast phenotype characterized by alpha smooth muscle actin (a-SMA) upregulation and stress fiber formation. Transforming growth factor-β (TGF-b) plays an …
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Development of a gamma ray telescope for online synovial dosimetry in boron neutron capture synovectomy
… for online monitoring of the accumulated synovial boron dose. This thesis explores the feasibility of developing a telescope system for online determination of synovial boron dose for accelerator-based BNCS. The Monte Carlo code MCNP was used to design the telescope system. The neutron and …
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