Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"synaptophysin"”.
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Investigating Synapse Function In Organotypic Hippocampal Slice Culture Models of Neurodegeneration
… and progressive loss of the presynaptic protein synaptophysin; however, direct analysis of functional changes in this model has not yet been achieved. Additionally, wild type mice exposed to the inflammatory molecule Lipopolysaccharide (LPS) experience similar loss of presynaptic protein, …
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Dynamic changes in the localization of synapse associated proteins during development and differentiation of the mammalian retina
… associated proteins Synaptotagmin, Rab 3A, Synaptophysin and Synaptobrevin, and presynaptic terminal membrane associated proteins SNAP-25 and Syntaxin, to characterize their spatio-temporal distribution during retinal differentiation and in the mature retina;The vertebrate retina has a …
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Genetic analysis of synaptogyrin function in the synaptic vesicle cycle
… exocytosis, and endocytosis. Synaptogyrin and synaptophysin are abundant and evolutionarily conserved synaptic vesicles proteins that were identified over twenty years ago, yet their exact function in the synaptic vesicle cycle remains unknown. To further elucidate the role of these proteins, …
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Effects of long-term hormone treatment on cognitive behavior and the structure of the medial prefrontal cortex during aging in female rats
… stained for tyrosine hydroxylase and synaptophysin. Adjacent sections were Nissl stained to calculate volume and quantify neuron number. The medial prefrontal cortex was examined because it is involved in several cognitive tasks and is known to be sensitive to both aging and ovarian …
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The effects of magnesium administration on cardiac ventricular function, heart rate variability, and myocardial morphological changes in a chronic diabetes disease model in rats
… of the cardiac autonomic presynaptic marker (synaptophysin) and of the mitochondrial marker of oxidative stress (ATP5A) were performed on right atrial tissue. Plasma Mg2+ concentration was measured using automated photometric assays. Results: STZ treatment significantly increased the blood …
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Revealing Mechanisms of Sporadic Alzheimer’s Disease by Modelling in Organotypic Hippocampal Slice Cultures
… decrease in the presynaptic protein synaptophysin. Next, lowering glucose concentration to model hypoglycaemia, causes an increase in Aβ in wild type OHSCs, which can be rescued with a variety of alternative fuel sources. And finally, OHSCs cultured from a mouse transgenic line show …
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Lateral Parabrachial Choline Acetyltransferase Neurons and the Decision to Eat
… dependent viral vectors to express mRuby tagged synaptophysin, the highest output being the central amygdala. Calcium dynamics were measured at the amygdala using the genetically encoded calcium indicator GCaMP. The dynamics around the decision to consume food were seen to be different between …
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Hdac6 Inhibition Reverses Long-Term Doxorubicin-Induced Cognitive Dysfunction By Restoring Microglia Homeostasis
… but no decrease in the presynaptic protein synaptophysin, in the hippocampus. I did not detect a significant decrease in mitochondrial function or morphology in brain synaptosomes, myelination in the cingulate cortex using Black Gold II staining, or changes in astrocyte reactivity as …
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Regulation of filopodia dynamics is critical for proper synapse formation
… and motility, but reduces the recruitment of synaptophysin positive presynaptic elements and the probability of forming stable axo-dendritic contacts. We provide evidence for the rapid transformation of filopodia to spines within hours of imaging live neurons and reveal potential molecules …
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Persistent “hijacking” of brain proteasomes in HIV-associated dementia
… the analysis of synaptic proteins. Decreases in synaptophysin correlated with immunoproteasome increases, indicating the potential for synaptic protein alterations associated with immunoproteasomes. Analysis of isolated nerve endings, or synaptosomes, revealed immunoproteasome increases in …
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Mesenchymal Stem Cells Therapy in Progressive Rat Model of Parkinson's Disease
… demonstrating triple-stained with NuMA, TH, and synaptophysin. Behavioral analysis revealed that hMSC treatment in MG-132-treated rats had a tendency of increase in mean stay time on the rod at a 25 rpm (p<0.1). In conclusion, we have shown that hMSC treatment have a protective effect of …
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The effect of exercise on spatial learning and hippocampal proteins in maternally separated adult rats
… location memory despite increases in levels of synaptophysin and phospho-extracellular signal-regulated protein kinase (pERK) in the hippocampus of non-separated-exercised rats. In the current study, the same MS technique and three-week voluntary exercise regimen were tested to determine their …
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Neuroendocrine neoplasms of the digestive tract: retrospective classification according to the 2019 WHO grading system, and evaluation of the immunohistochemical marker INSM1
… compared to chromogranin A (CgA) and synaptophysin (SYN). Sixty-nine GIT NENs diagnosed between 2003 and 2017 at Groote Schuur Hospital were included in this study. The mitotic rate and Ki-67 proliferation index were evaluated for each case. We identified 38 grade 1 NETs, 16 grade 2 …
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The neural cell adhesion molecule 2 (NCAM2) promotes excitatory synapse formation through increasing insulin and insulin-like growth factor 1 receptor signaling
… disrupts the normal developmental increase in synaptophysin and VGLUT1 levels but does not affect the developmental increase in VGAT levels. Synapse densities are reduced in NCAM2-deficient cultured hippocampal neurons when compared to NCAM2-expressing neurons. In NCAM2-expressing neurons, …
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Influence of food intervention on enteric nervous system and enteroendocrine cells development in a small for gestational age piglet model
… Neuronal markers (BIII tubulin (B3T), synaptophysin (SYN), neuropeptide Y (NPY), tyrosine hydroxylase (TH)) and EES markers (Chromogranin A (CoA), somatostatin (SOM), serotonin (SER), NPY, Neurotensin (NeuroT)) were used to assess the development of the ENS and enteroendocrine cells …
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Eine funktionelle Charakterisierung der frühendosomalen SNARE-Proteine
… Teil der vorliegenden Arbeit für SNAREs und Synaptophysin untersucht. Bisher war es aufgrund der geringen Größe von Endosomen (ungefähr 200 nm Durchmesser) sehr schwer, Aussagen über unterschiedliche endosomale Domänen zu treffen, da sie im Bereich der Auflösungsgrenze konventioneller …
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Developmental trajectory of synaptic vesicle recycling in wild type and neurodevelopmental disorder mqodels
… calcium influx from 3 days in vitro (DIV). Synaptophysin-pHluorin (sypHy) imaging indicated that SVs are recycled via evoked exocytosis and endocytosis from the first week in vitro as well, although the number of responsive nerve terminals continued to increase until the second week in …
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Synaptic vesicle protein 2A-dependent function and dysfunction at the presynapse
… activity. No observed effects of the drug on synaptophysin, vesicular glutamate transporter 1 (VGLUT1) and SYT1 recycling were observed, suggesting that LEV is unlikely to function as a modulator of excitatory presynaptic activity or by influencing SV2A function. In conclusion, this work …
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CHRONIC LOW-LEVEL LEAD EXPOSURE AFFECTS THE MONOAMINERGIC SYSTEM IN THE MOUSE SUPERIOR OLIVARY COMPLEX
Low-level lead (Pb) exposure is associated with behavioral and cognitive dysfunction. It is not clear how Pb produces these behavioral changes but low-level Pb exposure and learning disabilities have been associated with altered auditory temporal processing in both humans and animals. Temporal …
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CHRONIC LOW-LEVEL LEAD EXPOSURE AFFECTS THE MONOAMINERGIC SYSTEM IN THE MOUSE SUPERIOR OLIVARY COMPLEX
Low-level lead (Pb) exposure is associated with behavioral and cognitive dysfunction. It is not clear how Pb produces these behavioral changes but low-level Pb exposure and learning disabilities have been associated with altered auditory temporal processing in both humans and animals. Temporal …
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