Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"synapsin"”.
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Role of Synapsin In Long-Term Synaptic Facilitation In Aplysia
… expression of the presynaptic protein synapsin has been correlated with certain forms of long-term plasticity and learning and memory. However, the regulation and requirement for enhanced synapsin expression in long-term memory remains unknown. In the present study the technical …
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Molekulare und phänotypische Charakterisierung von Drosophila melanogaster Synapsin Mutanten und In-vivo Calcium Imaging
… bislang unbekannte regulatorische Elemente des Synapsin Gens identifiziert werden. Mit dieser Information sollte es möglich sein, einen Synapsin-„Rescue“ Vektor zu konstruieren, der nach Transformation in die Nullmutante den wildtypischen Phänotyp wiederherstellt. Beim Vergleich der im Rahmen …
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Molecular Anatomy of a Living Nerve Terminal: Actin and Synapsin in the Synaptic Vesicle Cycle
… the synaptic vesicle-associated phosphoprotein synapsin. The studies presented in this thesis were designed to investigate the role of the interaction between synapsin and actin in an intact model of synaptic transmission, the lamprey reticulospinal synapse. To establish the role of actin in the …
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Synaptic vesicle recycling <i>in Vivo</i>
… Knockout Stamm des Vesikel-assoziierten Proteins Synapsin. Tatsächlich konnten wir zeigen, dass Synapsin die Mobilität der nicht-aktiven Vesikelpopulation einschränkt. Außerdem führte der Knockout von Synapsin zu einem signifikanten Anstieg des Anteils aktiver Vesikel in vivo. Synapsin ist also …
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Die Rolle von transformierenden Wachstumsfaktoren-beta (TGF-β) in der Entwicklung von Synapsen
… Einfluss von TGF-β auf die Phosphorylierung von Synapsin untersucht, da diese zu einer Umverteilung der Vesikel in den synaptischen Terminalien beiträgt. Es konnte eine erhöhte Phosphorylierung verschiedener Synapsin-Isoformen nach akuter Behandlung mit TGF-β und eine Hypophosphorylierung nach …
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Identifizierung und Charakterisierung von Interaktoren des zellulären Prion-Proteins
… mit PrP näher zu charakterisieren: Pint1, Synapsin Ib und Grb2. Mittels Copräzipitation konnte bestätigt werden, dass auch in Säugetierzellen eine physiologische Wechselwirkung zwischen den identifizierten Interaktoren und PrP auftritt. Das Protein Pint1 wurde bislang noch nicht beschrieben …
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The glutamate hypothesis of depression: the effect of stress and glucocorticoids on glutamate synapse and the action of antidepressants
… Finally we found that stress and CORT modulated synapsin I, a protein involved in vesicle mobilization and in vesicles docking, fusion and recycling at active zones. We found that both FS-stress and CORT induce an increase of synapsin I phosphorylation in synaptic membranes selectively at site 1. …
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Seasonal plasticity of A15 dopaminergic neurons in the ewe
… on A15 neurons varies with season by examining synapsin-positive close contacts on A15 cells using immunofluorescence and confocal microscopy. The number of contacts on dendrites, but not somata, increased during anestrus. There were also corresponding changes in dendritic morphology including …
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CaMKII at a central synapse : α-calcium/calmodium protien kinase II and synaptic plasticity at CA3 Schaffer collateral -- CA1 synapses in the mammalian hippocampus
… that CaMKII phosphorylation of pre-synaptic synapsin I is not required for LTP expression. Contextual and cued fear conditioning were also normal in CA3 mutants, demonstrating that one form of hippocampus dependent learning is intact.
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Environmental influences on the development of the female honeybee brain Apis mellifera
… mit Fluor-Phalloidin und anti-Synapsin Immuncytochemie durchgeführt. Diese Doppelmarkierung ermöglichte die Visualisierung und Quantifizierung individueller Synapsenkomplexe (Microglomeruli) im Pilzkörper-Calyx. Phalloidin bindet an verschiedene F-Aktin Isoformen und kann zum …
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IMPACT OF PESTICIDES ON THE NEURAL STRUCTURE OF THE HONEY BEE, APIS MELLIFERA
… immunolabeling of the pre-synaptic marker anti-synapsin I and laser scanning confocal microscopy. This permits visualization of synaptic complexes called microglomeruli. Exposure of worker honey bees to fipronil at field-realistic (1 ppb), as well as lower (0.1 ppb) and higher (4 ppb) …
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Auswirkungen der Überexpression von neuronalem p21ras auf cholinerge Septumneurone der Maus : eine stereologische Studie
… unter der Kontrolle des neuronenspezifischen Synapsin I-Promotors exprimiert. In adulten p21ras-transgenen Mäusen konnte hier gezeigt werden, dass das Transgen im Hippokampus deutlich stärker exprimiert wird als im MS. Um einen neurotrophen Effekt der p21ras-ÜBerexpression auf cholinerge …
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Transient CaMK-II Activation is Necessary for Left-Right Asymmetry in the Zebrafish Embryo
… linked CaMK-II to secretion (mediated through synapsin I) and to bipolar spindle formation in mammalian cells, among other cellular functions. In mammals, CaMK-II is encoded by four genes: α, β, δ, and γ. In zebrafish, like other teleost fish, gene duplication has yielded eight genes (α, αKAP, …
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Persistent “hijacking” of brain proteasomes in HIV-associated dementia
… with increases in 14-3-3 zeta and decreases in synapsin 1. These findings suggest “hijacking” of constitutive proteasomes by immunoproteasomes with the persistent inflammatory response in HIV-infected brains. Ubiquitin-mediated protein turnover by constitutive proteasomes is consequently …
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Gene therapy for axon regeneration
… serotypes and four promoters (CMV, mPGK, sCAG, synapsin) in their efficiency to express eGFP following injection at the sensory-motor cortex in mice and rats. The data suggests that AAV1 is the superior serotype to target layer V cortical neurons. Furthermore, the mPGK and synapsin promoters are …
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Calcium-Stimulated Adenylyl Cyclases are Critical Modulators of Fear Learning and Experience-Dependent Plasticity
… deficits after learning as measured by p-synapsin. The CA1 LTP results coincide with the above data as DKO mice, but not AC8 Rescue mice, show impaired LTP. Finally, WT mice show changes in CF memory strength that is dependent on prior environmental exposure, but DKO mice do not, …
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Expression of the repressor element-1 silencing transcription factor (REST) is regulated by IGF-I and PKC in human neuroblastoma cells
… 43 (GAP-43; a gene not regulated by REST) and of synapsin I and βIII tubulin (genes regulated by REST), proteins involved in the early stage of neuronal development. We observed that differentiation of SH-SY5Y cells by IGF-I and PMA was accompanied by a significant increase of these neuronal …
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Analysis of the expression and effects of vascular endothelial growth factor family of molecules on Fragile X Syndrome abnormalities in a mouse model
… Chapter 3 we found that through blocking VEGF-A, Synapsin-1 levels (a presynaptic marker) were reduced to wildtype (WT) levels and resulted in a rescue of physical and behavioral FXS phenotypes (Belagodu et al., 2017). Chapter 4 explored and characterized ultrasonic vocalization (USV) …
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Evaluating the Therapeutic Effect of an Hsp90 Inhibitor in Mouse Models of Alzheimer’s Disease
… such as Post-synaptic density 95 (PSD95), synapsin I, and brain-derived neurotrophic factor (BDNF), among others. Confocal imaging demonstrated rescued dendritic spines with 17-AAG treatment after Aβ challenge in neuronal culture models. The functionality of these changes in the synapse was …
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Examination of neocortical plasticity during forebrain-dependent trace-associative learning tasks
… Findings from Chapter 2 demonstrating increased synapsin I expression, a presynaptic marker, in the conditioned barrels following WTEB conditioning support that synaptic modifications occur following learning. Closer examination of learning-induced synaptic modifications in Chapter 3 …
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