Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 399 for “"synapse"”.
-
Signaling at the neuromuscular synapse
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1995.
-
Immunological synapse arrays : patterned protein surfaces that modulate immunological synapse structure formation in T cells
… T cell-APC interface known as the immunological synapse (IS). It remains unresolved whether the unique physical structure of the synapse itself impacts the functional response of T cells, independent of the quantity and quality of ligands encountered by the T cell. As a first step toward …
-
Computational modelling of the glycinergic synapse
… mutations to the components of the glycinergic synapse, for instance nonketotic hyperglycinemia (NHK) which leads to severe neurological problems. Moreover, the control of glycine concentration time course via the inhibition of glycine reuptake has been suggested as a potential novel treatment …
-
Neuroligins Determine Synapse Maturation and Function
… Reduktion der exzitatorischen und hemmenden Synapsen führt und diese Änderung bedingt infolgedessen die synaptische Übertragung in diesen Neuronen. Wir beobachteten ein unverändertes Verhältnis der symmetrischen und asymetrischen Synapsenanzahl in den Mäusen, denen alle drei Neuroligine …
-
Molecular Physiology of the Ribbon Synapse
Durch Ca2+-Einstrom hervorgerufene Exocytose in den inneren Haarzellen (IHZ) der Cochlea ist ein kritischer Schritt für die Wahrnehmung von Geräuschen. In dieser Arbeit wurde mit Hilfe von knock-out-Mäusen die Regulierung von Ca2+-Kanälen in IHZ der Maus durch die CaV(beta)2 Ca2+-Kanaluntereinheit …
-
Dreidimensionale Rekonstruktion einer exzitatorischen zentralen Synapse : die Held`sche Calyx - Prinzipalneuron Synapse im medialen Nucleus des Trapezkörpers
… einer Held´schen Calyx - Prinzipalneuron Synapse im medialen Nucleus des Trapezkörpers (MNTB) aus seriellen Ultradünnschnitten einer postnatal Tag 9 alten Ratte. <br>Der Calyx ist eine sehr große (ca. 20-25 µm im Durchmesser) und komplex aufgebaute glutamaterge axosomatische …
-
Synapse Formation in the Zebrafish Lateral Line
… pre- and postsynaptic partners are matched for synapse formation. The zebrafish lateral line offers the opportunity for greater insight into this process. Hair cells in the lateral-line neuromast exist as two intermingled subpopulations, anteriorly and posteriorly polarized cells. Afferent …
-
Mechanisms of Synapse Formation and Synaptic Plasticity
Synapses are the fundamental building blocks of the nervous system. Following target cell contact, they are formed through a process that requires the precise orchestration of both pre- and postsynaptic differentiation of synaptic machinery. However, the precise time course of synaptogenesis, and …
-
Role of Neuroligin in Synapse Formation and Autism
… binds only beta -neurexin more potently promotes synapse formation in hippocampal neurons, whereas neuroligin 1 lacking splice site B, which binds both alpha - and beta -neurexins, is more efficient at synapse expansion. Mutations in two surface loops of neuroligin 1 abolished neuroligin binding …
-
Visualizing inhibitory and excitatory synapse dynamics In vivo
… the properties of inhibitory and excitatory synapse dynamics are not well understood. To address this issue, we utilized triple-color two photon microscopy to examine inhibitory and excitatory synapses across time with daily imaging. We found that the majority of dynamic spines at these …
-
Transfer Properties of the Hair Cell-Afferent Fiber Synapse
… a transduction process achieved by the chemical synapses of hair cells in the auditory periphery. Thus, the operation of the hair cell's presynaptic active zone is key to understanding auditory transduction. However, the lack of suitable experimental systems in which to investigate both the …
-
Untersuchungen zum Zeitverlauf der Transmitterfreisetzung an einer glutamatergen Synapse
… elektrische Signale übermittelt. An chemischen Synapsen werden bei einer Erregung präsynaptischer Endigungen Transmittersubstanzen ausgeschüttet, die in Vesikeln gespeichert sind. Mit welchem genauen Zeitverlauf der Transmitter aus einzelnen Vesikeln abgegeben wird, ist nicht abschließend …
-
Kurz- und Langzeitplastizität an einer hippokampalen Körnerzell-Korbzell-Synapse
Die Körnerzell-CA3-Pyramidenzell Synapse stellt eine Hauptkomponente des <br>hippokampalen trisynaptischen Schaltkreises dar. Neuere Untersuchungen <br>jedoch legen nahe, daß inhibitorische Interneurone die <br>Hauptzielstrukturen des Moosfasersystems darstellen. Um die Regulation <br>der …
-
Axon Development and Synapse Formation in Olfactory Sensory Neurons
… model for the study of axonal growth and synapse formation. The present set of studies attempts to provide insights into synapse formation and axonal development of olfactory sensory neurons. First, I sought to understand the regulation of expression of pre-synaptic molecules in the …
-
Mechanisms underlying retinogeniculate synapse formation in mouse visual thalamus
Retinogeniculate (RG) synapses connect retinal ganglion cells to the thalamic relay cells of the dorsal lateral geniculate nucleus (dLGN). They are critical for regulating the flow of visual information from retina to primary visual cortex (V1). RG synapses in dLGN are uniquely larger and stronger …
-
The Role of Stac3 in Neuromuscular Synapse Elimination and Maturation
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
-
Filopodial Dynamics and Synapse Specification in the Drosophila Visual System
… array of genes required for various steps of synapse specification. However, it remained unclear how these genes implement the developmental rules that result in the final connectivity and we understand very little of what actually goes wrong between a particular genetic perturbation and the …
-
Tsyn-Seq: A T Cell Synapse-Based Antigen Identification Platform
… We present a new antigen screening method, the T-synapse (Tsyn) reporter system, which includes antigen-presenting cells (APCs) with a Fas-inducible NF-κB reporter and T cells with a nuclear factor of activated T cells (NFAT) reporter. To functionally screen for target antigens from a cDNA …
-
Regulation of filopodia dynamics is critical for proper synapse formation
… that regulate the formation and development of synapses remain poorly understood. Indeed, the mechanisms through which initial synaptic contacts are established and modified during synaptogenesis have not been fully determined and a precise understanding of these mechanisms may shed light on …
Page 1 of 20