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Showing 1 to 20 of 147 for “"succinate"”.
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Inhibition of Succinate Oxidation in Tomato Fruit Mitochondria
Made available in DSpace on 2014-12-10T17:53:07Z (GMT). No. of bitstreams: 1 6801742.pdf: 2324593 bytes, checksum: 87718b967d3eab0902d5618c2ce91f9f (MD5) Previous issue date: 1967
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Developing drugs to attenuate succinate accumulation and oxidation
… Mitochondria are at the heart of IR injury, with succinate dehydrogenase (SDH) a major player in orchestrating the damage. Succinate accumulates during ischaemia and is rapidly oxidised by SDH upon reperfusion, producing reactive oxygen species (ROS), leading to cellular death. I have investigated …
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Analysis of the Metabolism of Dextran-Methylprednisolone Succinate Using
… acid linker to form Dextran-methylprednisolone succinate @exMPS). A newly developed reversed-phase HPLC assay is validated, and is capable of simultaneous measurement of methylprednisolone (MP), methylprednisolone succinate (MPS), methylprednisone (MPN), and corticosterone (CST) in addition to …
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Microglial succinate receptor 1 (SUCNR1) sustains chronic CNS inflammation
… signalling modalities. Among these, succinate signalling via succinate receptor 1 (SUCNR1) plays a key role in controlling myeloid cells responses in systemic inflammatory conditions. However, how the succinate-SUCNR1 axis regulates myeloid cell functions in the central nervous system …
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Aspartate Transcarbamylase - Succinate Complexes: A Proton Magnetic Relaxation Study
Made available in DSpace on 2014-12-10T23:02:00Z (GMT). No. of bitstreams: 1 7511565.pdf: 7734299 bytes, checksum: e154f79fbf9939b27ecaf60d978c0796 (MD5) Previous issue date: 1974
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Ruminal Degradation of Polyhydroxyalkanoate and Poly(butylene succinate-co-adipate)
… polyhydroxyalkanoate (PHA) and poly(butylene succinate-co-adipate) (PBSA) biodegradable materials for feed storage products such as bale netting could reduce the incidences and effects of polyethylene-based plastic impaction in ruminants. The objectives of these studies were to evaluate the …
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Investigation of Gut-Derived Circulating Succinate in Metabolism and Liver Signaling
… signaling molecules. The TCA cycle intermediates succinate and α-ketoglutarate are specific natural ligands for previously orphan receptors GPR91 (Sucnr1) and GPR99 (Oxgr1), respectively. The function of Sucnr1 is more extensively studied and its activation by succinate regulates pleiotropic …
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Metabolic engineering and modelling of Escherichia coli for the production of succinate
… sustain a green chemical industry in the future. Succinate is one of those biochemicals. Today, this compound is synthesised via maleic anhydride, which is produced by a petrochemical production process. The conditions which a biological production processes have to meet to be economically viable …
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Cell Toxicology Study of RRR-Alpha-Tocopheryl Polyethylene Glycol 1000 Succinate (TPGS).
… of RRR-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) in transformed and cancerous cell lines. We used RAW264.7 macrophage and prostate cancer (LNCaP) cell lines in this study. TPGS caused cell death and decreased cell viability in a dose and time dependent manner. Cell death was …
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Inhibitation of succinate oxidation in beef heart mitochrondria by derivatives of pyridine adenine dinucleotide
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Neural stem cells respond to extracellular succinate via SUCNR1/GPR91 to ameliorate chronic neuroinflammation
… NSC transplantation reduces the immunometabolite succinate in the cerebrospinal fluid, while decreasing the burden of mononuclear phagocyte (MP) infiltration and secondary CNS damage. Mechanistically, the anti-inflammatory activity of NSCs arises in response to succinate released by inflammatory …
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Inhibition of Bacillus subtilis respiration on glucose, formate and succinate by certain anesthetic agents
… subtilis</i> Koch-Novy with glucose, formate and succinate as substrates. The enzymatic oxidation of these substrates in the presence of cyanide, urethane, chloral hydrate, chloroform and other have been investigated and the effects of these agents over a range of concentrations have been noted. …
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Investigation of Enhancement of Furosemide Solubilization with Cyclodextrins and a Novel Octenyl Succinate Anhydride Starch
<p>Solubility behavior is one of the most challenging aspects for drug commercialization and often the main reason of drug that do not reach to its full potential. Now nearly 60% new chemical entities possess solubility problems, whereas practically no drug products with less than 10 µg/ml …
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Application of metabolic and biochemical engineering techniques to enhance metabolic flux throughput and improve succinate production in Escherichia coli
… encouraging the use of this system to improve succinate levels. Further, overexpression of the feedback resistant Sorghum PEPC in the host was coupled to three pathway manipulations: ackA-pta mutant, ackA-pta-nuo mutant, and ackA-pta-nuo-ldh mutant, with a high yield value of 0.65 mole …
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A study of succinate dehydrogenase deficient tumourigenesis: From functional assessment of variant pathogenicity to the discovery of new disease biomarkers
… function of the citric acid cycle enzyme complex succinate dehydrogenase (SDH) is associated with a predisposition to a spectrum of tumourigenesis including phaeochromocytoma, paraganglioma (1) (PPGL), gastrointestinal stromal tumours (GIST) (2), renal cell carcinoma (RCC) (3) and pituitary …
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Metabolic network design and engineering in Escherichia coli
… yield and enhance cellular properties. The succinate synthesis pathways in E. coli were chosen as the model system for network design and optimization. The ultimate goal is to create succinate production systems in E. coli that not only achieve the maximum theoretical yield of succinate, but …
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Cell Toxicity and Uptake of RRR-Alpha-Tocopheryl Polyethylene Glycol 1000 Succinate (TPGS) by Various Cell ines <em>In Vitro</em>.
… of RRR-alpha-tocopheryl polyethylene glycol succinate (TPGS, with that of alpha-tocopheryl succinate (α-TS). Both TPGS and α-TS are water-soluble forms of vitamin E with important clinical applications. Cytotoxicity assays with RAW 264.7 and LNCaP cells incubated overnight with TPGS or α-TS …
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A Major Cell Envelope Protein Of Escherichia Coli K12: Purification And Properties
… protein from E. coli K12, the so-called "succinate eluted protein" (SEP) is reported. SEP was released by EDTA-sucrose and osmotic shock treatments, or during the formation of spheroplasts. The protein was purified on columns of aspartate-Sepharose (A-S) an affinity matrix previously used …
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Mitochondrial Metabolism in Ischaemia Reperfusion Injury
… to IR injury, and the respiratory complex succinate dehydrogenase (SDH) has been identified as a new therapeutic target. The mitochondrial metabolite succinate accumulates during ischaemia, before being rapidly oxidised by SDH upon reperfusion, producing reactive oxygen species (ROS), and …
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Studies on Methylmalonyl-CoA Mutase from Escherichia coli
… utilisation of unusual carbon sources such as succinate and propionate. An insertion mutant of the sbm gene created by transposon mediated mutagenesis was used for investigating the role of this gene. The wild type E. coli K12 strain, E. coli TR6524 and the mutant E. coli K12 (sbm::MudJ) were …
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