Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 339 for “"splice"”.
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Computational methods for splice site prediction
… the exons are the coding regions that are spliced together during the mRNA maturation process. The borders between exons and introns present conserved dinucleotides, and are called splice sites; the intron-exon boundary is referred to as acceptor splice site and the exon-intron boundary as …
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Isolation of novel ABF-1 splice forms
… Here we report the isolation often novel ABF-1 splice products from a human B-cell plasmacytoma cell line. Analysis of the nucleotide sequence revealed approximately five clones harboring changes within the coding region of the reported full-length ABF-1 eDNA. In some cases, these changes …
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Generating single-domain antibodies against fibronectin splice variants
… single-domain antibodies which bind to splice variants of fibronectin containing EIIIA or EIIIB. Alpacas were immunized with either purified antigen cocktails, or from the ECM of tumor samples, and antibody libraries were generated. Using these libraries to pan against, I selected for …
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Retrofit of deficient lap splice with post-installed anchors
… efficient retrofit solutions, with deficient lap splices being one of many research areas. A possible method to increase the capacity of deficient lap splices is to use post-installed undercut anchors. These anchors function as active confinement in the splice region, potentially allowing members …
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INTERACTIONS OF ADAM15 SPLICE VARIANTS WITH SH3 DOMAIN PROTEINS
… domain (ICD) of ADAM15 exists in multiple splice variants that contain varied combinations of polyproline regions, which interact preferentially with proteins containing Src Homology 3 (SH3) domains. Patients suffering from node-negative breast cancer exhibited a poorer prognosis when …
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Fibronectin splice isoforms in wound healing and vascular development
… few specific functions of the alternatively spliced isoforms have been described. Studies of the expression patterns of the splice isoforms show that these proteins are present at high levels during embryonic development. In adult animals, these isoforms are expressed around the perimeter of …
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The localisation and regulation of phosphatidylinositol-4-phosphate 5-Kinase gamma splice variants and the discovery of a new mammalian splice variant, PIP5KIγ_v6
… found. PIP5KIr is subject to complex C-terminal splice variation, enhancing its transcriptional diversity through evolution and producing at least 5 known spliceoforms in the mammals. This study addresses several important questions. (1) Several remarkable differences have been discovered between …
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Role Of d16HER2 Splice Variant In Breast Cancer Stem Cells
The transmembrane tyrosine kinase receptor HER2 is overexpressed in about 20% of human breast cancers (BCs). Evidence suggests that the co-existence of the full-length/wild-type HER2 oncoprotein (WTHER2) with its altered isoforms increases the heterogeneity of HER2 overexpressing (HER2+) disease …
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Molecular and Pharmacological Characterization of the Rat RAMP2B Splice Variant
… CL complex. A partial sequence of a rat RAMP2 splice variant was previously identified in our laboratory. I hypothesized that human tissue expresses RAMP2 splice variants and that a clone of the full-length rat RAMP2 splice variant forms an adrenomedullin receptor with decreased function in the …
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Quantitative modeling of 5' splice site subclass regulation and evolution
… LUC7 family, compete to differentially impact 5→ splice site (5→ SS) selection in a sequence-dependent manner. I quantitatively characterize two major subclasses of 5→ SS in eukaryotes and outline distinctive features of 5→ SS in exons affected by the three human LUC7 paralogs: LUC7L2 and LUC7L …
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Axial offset effects upon optical fiber sensor and splice performance
A kind of intensity modulated fiber sensor utilizing axial offset parameter is proposed. The theoretical analysis and experimental characteristics of this sensor are described. All the theoretical results derived in this thesis are based on assuming a uniform power distribution in the fibers. An …
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Identifying the signalling pathway of a novel Myostatin Splice Variant (MSV)
… The discovery in our laboratory of a novel splice variant of Mstn (MSV) that opposes Mstn and stimulates the proliferation of myoblasts provided the impetus for the investigations in this thesis. The splicing of MSV was restricted to the Cetartiodactyl clade of mammals, and MSV may represent …
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Tapered Splice for Efficient Power Coupling to Small-Core Nonlinear Fibers
… improved over that obtained by the butt-joint splice. This technique uses a highly tapered splice in which the field leaves the core and propagates as a fundamental cladding mode before it couples back to the core mode of the small core fiber. At the beginning of the taper the fundamental core …
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The Role Of Pdgf C And Its Splice Variant In Breast Cancer
… During the course of our study, we discovered a splice variant of PDGF C encoding the truncated PDGF C protein (t-PDGF C). Specific aims of this dissertation are to determine the role of full-length PDGF C (FL-PDGF C) and t-PDGF C in breast cancer and to characterize their subcellular …
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Splice Factor SFRS6: Regulation by p53 and Effect on IL-24 Splicing
… as a major mechanism for expanding the proteome. Splice pattern changes are found in numerous diseases and cancers, indicating the importance of tight control over this process. While the mechanism of splicing has been described in detail, it is less clear how a cell is able to modify its splicing …
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Sequences and factors required for 5' splice site selection in Schizosaccharomyces pombe
… of U1 snRNA complementary to the 5$\sp\prime$ splice site in S. pombe with the goal of expanding our knowledge of how this sequence functions in pre-catalytic events in pre-mRNA splicing. To determine the contribution to U1 function of each position complementary to the first six nucleotides of …
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Evaluating the Performance of in Silico Predictive Models on Detecting Splice-altering Variants
… of this study is to determine the ubiquity of splice-altering variants (SAVs) in the human genome with a focus on coding missense and silent synonymous polymorphisms that may impact splicing. As a first step, we evaluated the ability of in silico prediction tools to predict whether a given …
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Lap Splice Development Length of Rebar in Stabilized Hollow Interlocking Compressed Earth Blocks
… the tensile performance of unconfined lap splices in specimens constructed from interlocking compressed earth block (ICEB) units. All lap splice specimens were constructed from hollow ICEB half units with one side grouting channel. ICEB units used in this research were exclusively produced …
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An experimental investigation of stress relations among the rivets of a web splice
Thesis: B.S., Massachusetts Institute of Technology, Department of Architectural Engineering, 1936
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