Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"skeletal development"”.
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Aberrant Ras/MAPK signaling in skeletal development
… have focused on the roles of this pathway during development and have modeled syndromes, such as Noonan Syndrome (NS), that are caused by aberrant germline Ras/MAPK signaling. One hallmark of these developmental syndromes is a defect in the skeletal development of the patients. However, the in …
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E2F6 in axial skeletal development and gliosis
… novel roles for these proteins in different developmental processes. This dissertation examines the biological role of E2F6 in mammalian development. E2F6 functions as a repressor of transcription in concert with the polycomb group (PcG) proteins and chromatin modifiers. PcG proteins regulate …
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A Novel Role for HAPLN1 in Skeletal Development
… animal models support differences in cartilage development in the pathogenesis of AIS. Here, we performed genome sequencing in families with inherited AIS and identified a co-segregating rare variant in the HAPLN1 gene. HAPLN1 encodes Hyaluronan and Proteoglycan Link Protein 1, also known as …
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Leukemia Inhibitory Factor (LIF): Murine Preimplantation Embryo Development, Implantation Rates, and Skeletal Development
… effects pre-implantation and post-implantation development. The objectives of this project were to determine the effects LIF on pre-implantation development, to determine the effects that it may have on implantation rates, successful pregnancy rates, and resorption rates, and to determine the …
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Age estimation using epiphyseal closure at the wrist joint : an investigation of individuals of African origin, age 14 to 22 years
… date of birth, to the level of functional and skeletal development known as biological age. This is useful in forensic cases where the age of an individual whether living or post mortem is often unknown.
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Predictive Modelling of Bone Ageing
… diagnosis of growth disorders through monitoring skeletal development; secondly, prediction of final adult height; and fi�nally, verifi�cation of age claims. Manually predicting bone age from radiographs is a di�fficult and time consuming task. This thesis investigates bone age assessment and why …
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Interactions between BMP and Canonical Wnt Signaling Regulate Critical Stages of the Osteoblast Lifecycle
Skeletal development and post-natal bone homeostasis are dependent on the coordinated activity of bone-forming cells called osteoblasts and bone-resorbing cells called osteoclasts. Over 10 million people in the US currently suffer from osteoporosis, which increases the risk of low-trauma fractures …
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Construction of a COL11A1 Transgene Vector
… States alone, with effects ranging from poor skeletal development and joint pain to shortened lifespan and perinatal lethality. Many of these disorders have their root in defects of collagen, type XI collagen being among the most important. A mouse model of such a type XI collagen defect is …
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Bone growth during puberty and the effects of exercise and calcium on bone mass accrual
… periods characterised by the rapid growth and development of the skeletal system. The timing and magnitude of skeletal development varies considerably between individuals however, environmental factors may make significant contributions to the variance in bone mass. To optimise the development …
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Signaling mechanisms and developmental function of fibroblast growth factor receptors in zebrafish
… signaling plays multiple inductive roles during development of vertebrates (Itoh 2007). Some Fgfs, such as Fgf8, are locally secreted and signal over a long range to provide positional information in the target tissue (Scholpp and Brand 2004). Fgf ligands signal in a receptor-dependent manner via …
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Equine proximal phalanx bone properties during growth
… long benefits for bone health. However, normal development must be characterized in order to evaluate the effect of exercise during post-natal skeletal development. Three Standardbred trotting colts were longitudinally CT scanned between 2 and 12 months old. Finite-element models were …
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The roles of Rb, p107, and E2f4 in bone formation and embryonic development
… pRb, E2F4, and p107, in murine embryonic development and in differentiation in vitro. As Rb loss causes embryonic lethality due to placental defects, we adopted a conditional knockout strategy to generate Rb-deficient embryos that survive to birth. This approach allows us to assess a role …
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Bmp-Signaling Regulates A Common Transcriptional Program to Control Facial Form and Skeletal Morphogenesis
… plays critical roles in normal craniofacial development, and Bmp4 deficiency results in craniofacial abnormalities, such as cleft lip and palate. We performed an in depth analysis of <em>Bmp4</em>, a critical regulator of development, disease, and evolution, in the CNC. Conditional …
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Incorporación de vitamina C en dietas larvarias y su implicación en el desarrollo de Solea senegalensis
… vitamin deficiency during first feeding on the development and antioxidant defence system and its involvement in various metabolic pathways. The pattern of ascorbic acid content during the larval stage of sole was also determined and, for the first time, a mechanism of vitamin C transport at the …
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Developing a Caenorhabditis elegans Model for Marfan Syndrome
… and is required for proper cardiac and skeletal development and for sequestration of TGFβ (transforming growth factor beta) and BMP (bone morphogenetic protein) within the extracellular matrix (ECM). The primary objective of this study was to establish a C.elegans MFS model and use this …
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Hormonal regulation of bone health: novel understandings of xenoestrogens and estrogen receptor-[alpha]
… countries, but the impact of these compounds on skeletal health in males and females remains unknown. In this dissertation, we used animal models to explore a, the importance of estrogen receptor-[alpha] (ER[alpha]) in male mice at different points in the life cycle and b, the long-term impact of …
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A Qualitative and Quantitative Analysis of the Juvenile Ischium
… factors that drive early ontogenetic change in skeletal microarchitecture are less easily discerned, however, and appear to include not only functional interactions, but also genetic and epigenetic components that may form a blueprint for future development.<br/><br/>The increasingly …
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The Role of Slow-Twitch Skeletal Muscle in the Musculoskeletal Endocrine Axis
… mechanically to produce movement, the musculoskeletal unit has an endocrine function, capable of signaling to distant tissues as well as locally through the release of hormone-like molecules. Musculoskeletal disuse triggers loss of bone and skeletal muscle function while exercise improves …
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Age estimation in the living: a test of 6 radiographic methods
… compared in order to assess the child’s stage of skeletal development in relation to their chronological age, a purpose for which they are still utilised in the medical community. These atlases provide a testable link between skeletal age and chronological age which has been recognised by forensic …
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Characterization of a Novel Nuclear Variant of Bmp2 and Coordinate Regulation of Col11a2 and Col27a1 by the Transcription Factor Lc-Maf
… It has since been implicated in broad variety of developmental, patterning, and disease processes. To date, Bmp2 has only been known to function as an extracellular signaling molecule. However, we have obtained clear evidence for a nuclear form of Bmp2. This nuclear variant, nBmp2, contains a …
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