Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"severe asthma"”.
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The role of cough in severe asthma
Rationale: <br/>Cough is a common symptom within asthma that is both important and troublesome for patients and has been shown to be associated with a less well controlled disease. However, the role of cough within asthma is not well understood and there is little knowledge as to how cough is …
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Evidence for enhanced oxidative stress in smokers with severe asthma
… information was collected from cohorts of adult severe asthma smokers/ex-smokers (SAs/ex) and severe asthmatic non-smokers (SAn). Oxidative stress in SAs/ex vs SAn patients was investigated by analysing urinary 8-iso-PGF2a and the mRNA expression of the main pro-oxidant (NOX2; NOSs) and …
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GENETIC ANALYSIS OF THE GLUCOCORTICOID PATHWAY IN THE SEVERE ASTHMA RESEARCH PROGRAM
Asthma is a common lung disease affecting approximately 10% of the population in the United States. Approximately 10% of the individuals with asthma have a severe form of asthma that is inherently difficult to treat due to a poor response to treatment, namely inhaled corticosteroids (ICS). …
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The role of autophagy in allergic inflammation: a new target for severe asthma
… 10 III.RESULTS 12 1. The establishment of severe asthma model 12 2. The level ofLC3 expression in severe asthma model 15 3. Electron microscopy results 16 4. Inhibition of autophagy improved AHR and airway inflammation 17 5. Knockdown of Atg 5 attenuates AHR and airway inflammation 20 6. …
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The synthesis & optimisation of irreversible ITK inhibitors as a potential new treatment for severe asthma
… are involved in the inflammatory response in asthmatic patients. ITK inhibitors could represent useful anti-inflammatory agents for severe asthma. This thesis describes the design and development of irreversible ITK inhibitors. It was envisaged that these compounds could provide a better …
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Development of two disease specific scales to assess the impact of severe asthma on patients' lives
… disease specific scales to assess the impact of severe asthma on patients’ lives Asthma is a disease of the airways, characterised by airway obstruction, inflammation, and hyper-responsiveness resulting in symptoms of breathlessness, wheeze, shortness of breath and chest tightness. Severe asthma …
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Autophagy mechanisms in sputum and peripheral blood cells of patients with severe asthma: a new therapeutic target
… to potentially play roles in the development of asthma. However, little is known about the role of autophagy in the pathogenesis of severe asthma. Objective: We compared autophagy in the sputum granulocytes, peripheral blood cells (PBCs), and peripheral blood eosinophils (PBEs) between patients …
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A retrospective review of all children admitted with acute severe asthma to the paediatric intensive care unit, Red Cross War Memorial Children's Hospital between 2009-2019.
Background and Aim Asthma is one of the commonest chronic conditions of childhood and affects children worldwide. The majority of children who experience an acute exacerbation of asthma do not require admission to a paediatric intensive care unit (PICU). There is limited data on the admission …
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Association and Impact of the Physical Environment on Physical Activity and Sedentary Behaviours in an Asthmatic Pediatric Population
… Physical Activity and Sedentary Behaviours in an Asthmatic Pediatric PopulationGiorge Voutsas Doctor of Philosophy Institute of Medical Science University of Toronto 2025 Abstract Background: Asthma prevalence has increased worldwide in recent decades, resulting in extensive use of emergency care …
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The experiences of living with asthma: an interpretative phenomenological analysis of the lived experience of adults with T2-low severe asthma and a systematic review of the experiences and perceptions of children with asthma
… eight adults' lived experience of T2-low severe asthma by utilising the methodology of interpretative phenomenological analysis, and a systematic review of the experiences and perceptions of children with asthma by utilising the methodology of thematic synthesis. Resulting themes and …
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Immunopathological and Structural Alterations in Difficult to Control Asthma
Asthma is a chronic respiratory disorder affecting an estimated 300 million people worldwide. Most patients with asthma can be controlled with bronchodilators and low to moderate dose inhaled corticosteroids. However, an estimated 5-10% of the population presents a more troublesome disease, often …
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Advancing Clinical Remission in Severe Asthma: Efficacy of a Comprehensive Management Strategy Guided by Airway Inflammometry and Bioimaging [Migliorare la remissione clinica nell'asma grave: Efficacia di una strategia di gestione completa guidata dall'infiammometria delle vie aeree e dal bioimaging]
Razionale: La remissione clinica è un obiettivo terapeutico composito nell'asma grave. Tuttavia, solo circa il 30% dei pazienti raggiunge la remissione clinica quando le decisioni terapeutiche sono guidate dai livelli di eosinofili ematici e FeNO. Obiettivi: Valutare l'efficacia di una strategia …
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Environmental risk factors for asthma in 13-14 year old African children
BACKGROUND: Asthma prevalence in African children is high and increasing, with more severe disease than that in high income countries. Specific factors driving the rising prevalence or disease severity are poorly understood. The aim of this study was to investigate environmental factors associated …
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THE ROLE OF THE IL4/13 PATHWAY IN THE GENETICS OF ASTHMA SEVERITY
… 4/13 pathway genes have been associated with asthma susceptibility; however the role of these genes in asthma severity has not been explored. We tested single nucleotide polymorphisms (SNPs) in the critical Th2 regulator GATA-binding protein 3 (GATA3) and other Th2 genes for association with …
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Prevalence and risk factors associated with asthma in adults: a multi-country survey
Background: The Global Asthma Network conducted a parent study that gathered data at the population level on children in two specific age groups, as well as on the adult caregivers of those children. The scope of this dissertation will be specifically narrowed down to examining the prevalence of …
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Molecular basis of gene-environment interactions in the pathogenesis of asthma and COPD
The origins of respiratory disease, such as asthma in childhood and COPD in later life are unclear. Maternal smoking during pregnancy and low birth weight is associated with increased risk of asthma, poor lung function in adults and COPD in old age. Exposure to oxidative stress and poor nutrition …
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Tactical planning optimization for campaign scheduling of active pharmaceutical ingredient production based on monoclonal antibodies
… of cancer, rheumatoid arthritis, psoriasis, severe asthma macular degeneration, multiple sclerosis and more. In recent years, industry trends and market pressure have driven pharmaceutical companies to focus efforts on increasing operational efficiency in order to reduce the financial burden …
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Corticosteroid-induced morbidity in asthma: costs and consequence
The economic burden of asthma is significant and distributed disproportionately among those with severe disease. Asthma-related deaths in more developed countries like the UK have stabilised or are in decline however recent evidence suggests that individuals with asthma face greater all-cause …
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Anti-Inflammatory Effect of Sulfur Dioxide and Sulfite on Cigarette Smoke Exposed Human Airway Smooth Muscle Cells
… of chronic inflammatory airway diseases such as asthma and COPD, including airflow restriction and release of pro-inflammatory mediators. While the response of HASMC to cigarette smoke exposure has been studied, the effects of sulfur dioxide on the cigarette smoke-induced inflammatory mediators …
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