Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"salmeterol"”.
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A Proof-of-Concept Study to evaluate the benefit from add-on therapy with montelukast versus salmeterol in children with asthma carrying the Arg/Arg-16 β2-receptor genotype
… adults, particularly in those exposed to regular salmeterol. There follows the presentation of a proof-of-principle randomised controlled trial of add-on therapy to inhaled steroids, with either oral montelukast or inhaled salmeterol, on children carrying the susceptible Arg-16 genotype over a …
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Vibrational spectroscopic techniques (Raman, FT-IR and FT-NIR spectroscopy) as a means for the solid-state structural analysis of pharmaceuticals
… ipratropium bromide, polymorphic forms of salmeterol xinafoate and two polymorphic forms of sulfathiazole were selected since they are used in the management of certain respiratory disorders and from different chemical and pharmacological entities along with some pharmaceutical excipients. …
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Modelling Β2Ar Regulation
… (ii) Three phenomenological models of salmeterol (a LABA)-induced GRK-mediated β2AR regulation; and (iii) One semi-quantitative, unified model of SABA-induced GRK-, protein kinase A (PKA)-, and phosphodiesterase (PDE)-mediated regulation of β2AR signalling. The various models were …
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Regulation of cAMP-Dependent Gene Expression in Airway Epithelial Cells: A Transcriptional and Pharmacodynamic Analysis
… cells (HBEC), the LABAs, indacaterol and salmeterol, promoted robust transcriptional responses. Functional annotation and gene ontology analyses identified genes with both anti-inflammatory and adverse effect potential. Moreover, there was significant overlap in gene expression changes …
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Darstellung neuer phosphorhaltigerChiralica aus Alpha-Aminosäuren und Pharmawirkstoffen sowie derenAnwendung in der stereoselektiven Synthese
… werden zur Synthese von Fluoxetin und Salmeterol benötigt. Es wurden auch neue 2- Chlor-1,3,2-oxaza- und diazaphospholidine-2-oxide und -thione dargestellt und als chirale Derivatisierungsreagenzien zur Bestimmung der Enantiomerenreinheit von Alkoholen und Aminen mittels 31 …
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Effect of Cigarette Smoke Exposure on Bronchial Hyperresponsiveness in Mice and Response to a Corticosteroid and/or a β2-Adrenergic Agonist and Effect of Cigarette Smoke Extract on Cytokines Release from U937 Cells.
… inhaled fluticasone propionate (FP) and/or salmeterol to determine and compare their efficacy in smoke exposed versus non-smoke exposed mice. We also investigated the effect of cigarette smoke extract (CSE) on the contractility of isolated mouse trachea in vitro. Since, alveolar macrophages, …
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The effect of genetic variation on asthma severity and treatment in childhood
… asthma on the regular long-acting ß2-agonist salmeterol. 4. I have shown that there is an increase in risk of exacerbations per copy of Arg16 allele in children and young adults with asthma on frequent (once daily or more) as required doses of inhaled salbutamol. This effect is not observed on …
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Evaluation of the Effect of Critical Process and Formulation Parameters on the Attributes of Nanoparticles Produced by Microfluidics. Design of Experiments Approach for Optimisation of Process and Formulation Parameters Affecting the Fabrication of Nanocrystals of Poorly Water-Soluble Drug Using Anti-solvent Precipitation in Microfluidic
… and permeability, namely Ibuprofen (IBU) and Salmeterol (SAL), was conducted using a continuous, controlled, and scalable system offered by microfluidic reactor with the incorporation of anti-solvent approach. The research explores the potential of this technology to enhance absorption rate …
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Sympathetic Neural Control of Inflammation by ADRB2-Mediated IL-10 Secretion
… Additionally, the ADRB2-specific agonist salmeterol rescued wild-type animals from a lethal LPS challenge, which was reversed by neutralizing anti-IL-10 antibody. These observations suggest that ADRB2 signaling is critical for controlling inflammation through the rapid induction of IL-10. …
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Therapeutic strategies, health status and quality of life among persons with asthma: A meta-analysis
… findings of three studies in which Zileuton and Salmeterol were studied supported that combined effect sizes yielded statistically significant improvement in perceptions of activity limitations, symptoms, emotional, environmental concerns and overall quality of life. A binomial effect size …
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Use of nanoemulsion liquid chromatography (NELC) for the analysis of inhaled drugs. Investigation into the application of oil-in-water nanoemulsion as mobile phase for determination of inhaled drugs in dosage forms and in clinical samples.
… method was optimised for the determination of salmeterol and fluticasone propionate in good validation data was achieved. This thesis shows that, in general, the performance of O/W NELC is superior to that of conventional High Performance Liquid Chromatography (HPLC) for the analysis of both …
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The Role of Hydrocortisone on the Development and Maintenance of Ion Transport Pathways Essential to Mucociliary Clearance in Differentiated Normal Human Bronchial Epithelial Cells
… and increasing airway caliber. LABAs, such as Salmeterol and Formoterol, are effective long-acting inhaled bronchodilators. These drugs stimulate increases in cAMP which activates protein kinase A (PKA) dependent signaling pathways in airway smooth muscle, leading to relaxation and a decrease …