Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"retrotransposons"”.
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Molekulare Charakterisierung des Retrotransposons Ylt1 der Hefe Yarrowia lipolytica
… (RT), RNase H (RH) und Integrase (IN). Das Retrotransposons Ylt1 kommt in verschiedenen Stämmen der Hefe Y. lipolytica vor. Die Transpositionsaktivität dieses Retrotransposon war nachweisbar. Die Aktivität des LTR-Promotors ist von der Kohlenstoffquellen abhängig. Acetat und Ethanol bewirken …
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Expression levels of non-autonomous retrotransposons in germ-line rodent tissues
… via an RNA intermediate and are referred to as retrotransposons. These elements mobilize using machinery from other retrotransposons and therefore are non-autonomous. It has been demonstrated that both nucleotide sequence and the 3’ A-tail are important contributors for successful amplification. …
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The Contribution of Retrotransposons to the Transcriptomes of Murine Somatic Cells
Retrotransposons comprise approximately 40% of the mouse genome. Once thought to be useless “junk” DNA, there is growing evidence that retrotransposons play crucial roles in genome evolution and gene regulation, and contribute to the transcriptome. Several studies have found functional …
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Non-LTR Retrotransposons in Mosquitoes: Diversity, Evolution, and Analysis of Potentially Active Elements
… focuses on non-Long Terminal Repeat (non-LTR) retrotransposons in the African malaria mosquito, Anopheles gambiae and other mosquito species. An unprecedented diversity of non-LTRs was discovered by genome analysis of the An. gambiae genome assembly. One hundred and four families were found by …
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Regulation of the ETn/MusD family of active mouse long terminal repeat retrotransposons
Long terminal repeat (LTR) retrotransposons account for approximately 10% of mouse and 8% of human genomes and may play a role in modifying gene expression. Many species harbor retrotransposon families encompassing both autonomous and non-autonomous members. Specifically, the mouse Early Transposon …
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Non-Parametric Analyses of the Regulatory Roles of LINE-1 Retrotransposons during Motor Neuron Differentiation
Background: Repetitive elements make up a large portion of eukaryotic genomes, constituting two-thirds of human genome. Although their functional importance were recognized as early as 1950s, study of their functions is stagnated despite the advancements in next-generation sequencing due to …
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The identification and characterization of inter- and intra-species genetic diversity derived from retrotransposons in humans
Retrotransposons, which used to be considered as “junk DNA”, have begun to reveal their immense value to genome evolution and human biology due to recent studies. They consist of at least ~45% of the human genome and are more or less the same in other mammalian genomes. Retrotransposon elements …
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Molekulare Charakterisierung von Ty3-gypsy-Retrotransposons als abundante Sequenzklasse des Centromers eines Minichromosoms in Beta vulgaris L.
… die molekulare Charakterisierung von Ty3-gypsy-Retrotransposons eines einzelnen Wildrüben-Centromers möglich. Die für die Wildrübe Beta procumbens spezifischen Satellitenrepeats pTS5 und pTS4.1 dienten der Selektion von BACs aus der Centromer-Region des PRO1-Minichromosoms. Die Identifizierung …
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Role of Retrotransposons as a Major Source of Intra- and Inter-Individual Epigenetic Variations in the Mammalian Genome
Transcription of retrotransposons is usually repressed by DNA methylation, but a few elements partially escape this repression mechanism. I used two approaches as my dissertation study to identify unmethylated intracisternal A-particles (IAPs) and also to understand why some of IAPs escape DNA …
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Análise comparativa de transposons classe II (CACTA e Mutator) nos genomas de Vigna unguiculada, Phaseolus vulgaris e Medicago truncatula
… um total de 5,64 Mb de transposons e 48,42 Mb de retrotransposons, distribuídos em todos os cromossomos de P. vulgaris; 14,04 Mb de transposons e 51,20 de retrotransposons em M. truncatula, e 2,38 Mb e 9,34 Mb de transposons e retrotransposons, respectivamente, em V. unguiculata. Todos …
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The study of ancient viral class II envelope fusion proteins within the viral retroelements of Nematoda and the nuclear plasmids of Dictyostelium
… Typically, retroviruses and related degenerate retrotransposons encode a hemagglutinin-like class I envelope fusion protein. A subset of Bel/Pao LTR-retrotransposons within the phylum Nematoda have acquired a phlebovirus-like env and utilized the encoded fusion machinery to escape the genome as …
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P53 Genes Act to Restrain Mobile Elements
… that p53 functions to restrict the activity of retrotransposons. Furthermore, Drosophila p53 genetically interacted with components of the piRNA pathway and, in complementation studies, normal human p53 alleles restrained these mobile elements, but mutant p53 alleles from cancer patients could …
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NANOPORE SEQUENCING AS A NEW TOOL TO EXPLORE COMPLEX TRANSCRIPTOMES
… Panel, to investigate alternative splicing, retrotransposons and RNA modifications on coding and non-coding RNAs in multiple cell lines and organoids. We have proven our capacity to assemble breast cancer cell lines, to retrieve annotated and unannotated protein coding and lncRNAs, to detect …
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The ancient and recurrent evolution of Apobec3 antiviral activity in primates
… that inhibit the replication of retroviruses and retrotransposons. Here, I characterize the antiviral activity of Apobec3DE across primate species and of Apobec3 family members across human populations. First, I show that human and chimpanzee orthologues of Apobec3DE inhibit retrotransposons that …
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Alu retrotransposition-mediated genomic variation within the primate order
Retrotransposons are an active family of mobile elements within primate genomes and the Short INterspersed Element (SINE) Alu is the most abundant member. These non-autonomous elements are responsible for introducing genomic diversity on an intra- and inter- species level that is useful in studies …
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THE ROLE OF RETROTRANSPOSITION AND EXOSOMAL DNA IN RADIATION-INDUCED GENOMIC INSTABILITY
… that the random insertion nature of the LINE-1 retrotransposons could be a cause of RIGI. The work in this thesis has aimed investigate the role of retrotransposable elements in the mechanism of RIGI. Three different cell lines (HF19, Caco-2, and MCF7) were used to investigate if clinically …
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Somatic retrotransposition in the cancer genome
… genome-wide using computational algorithms. Retrotransposons comprise 42% of the human genome and have the capacity to "jump" across the genome in a copy-and-paste manner. Recent studies have identified families of retrotransposable elements that are currently active. In fact, …
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Mammalian-wide interspersed repeats (MIRs) and their role in mammalian gene function and evolution
… genome plasticity and diversity. All classes of retrotransposons accumulate in the genome via a process termed retrotransposition, wherein the elements are reverse transcribed into RNA and inserted into the genome as DNA. Exaptation of these elements can provide additional or novel function for …
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Evolution of the mysRS element in the genome of rodent species
<p>Retrotransposons are a type of transposable element in which DNA copies are produced via an RNA intermediate and integrate into new chromosomal sites continually contributing to the dynamics of genomes. While sequencing the mys element among the Cricetidae family of rodents, we identified a …
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