Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"remdesivir"”.
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Biochemical mechanisms for selectivity governing RNA and DNA replication
… genome in less than 2 minutes. The ATP analog Remdesivir triphosphate, the only FDA approved treatment for COVID-19, was then studied to calculate the discrimination relative to ATP. We found that Remdesivir is incorporated more efficiently than ATP and acts as a delayed chain terminator, …
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Bundibugyo Versus Zaire Ebolaviruses: Examination of the Polymerase Complex as a Therapeutic Target
… inhibitors, of which the nucleoside analog remdesivir emerged as a lead candidate. Remdesivir was found to be highly effective at inhibiting primary transcription, and delayed treatment required a significantly higher concentration. Use of remdesivir was more effective at inhibiting BDBV …
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Structures, Functions, and Druggability of the SARS-CoV-2 Replication–Transcription Complex
… a target for clinically used antivirals such as remdesivir and molnupiravir. Faithful synthesis of viral RNAs by the RTC requires recognition of the correct nucleotide triphosphate (NTP) for incorporation into the nascent RNA, while antiviral nucleoside analogs must compete with the natural NTPs …
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Great Expectations: Phosph(On)Ate Prodrugs In Drug Design—Opportunities and Limitations
… such as cyclophosphamide, sofosbuvir, and remdesivir. The findings of this work have resulted in 1.) the development of a novel phosph(on)ate amidation reaction, 2.) the discovery of a novel promoiety, 3.) the synthesis of novel enolase inhibitor prodrugs with diverse mechanisms of …
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Identification and Characterization of the Mechanisms of Action of Novel Antiviral Compounds Targeting the Minimal Replication-Transcription Complex of SARS-CoV-2
… use for the treatment of COVID-19, namely remdesivir and molnupiravir. However, the absence of strong evidence of in vivo efficacy and safety still calls for the development of novel safe and potent antiviral drugs, that could combat this and other future threats from emerging …
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Functional Investigation of RNA Viral Helicases as Molecular Targets for the Discovery of Novel Antiviral Agents
… additive antiviral effect in combination with Remdesivir and Nirmatrelvir. A 3i related compound, derivative 4b, with retained NSP13 inhibitory activity and SARS-CoV-2 antiviral effect, exhibited also pan-helicases potential, showing to be active against WNV NS3 helicase. The result encouraged …