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Showing 1 to 20 of 45 for “"reductive amination"”.
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Defining the substrate scope of DNAzyme catalysis for reductive amination with aliphatic amines
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-05-01
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Charge-Transfer Complexes for Amine Synthesis
… acyclic aldehydes, by development of a radical reductive amination, using thiol as the single-electron reductant and hydrogen atom source. Subsequently, the chemoselective reductive amination of secondary amines over primary amines was attempted. Preliminary studies on a di-amine drug indicated …
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Synthesis and applications of aminated biopolymers
… economically viable process for biopolymer amination was sought via substitution of C-6 tosyl esters or via reductive amination of biopolymer aldehyde derivatives. To this end, C-6 amino cellulose was synthesised by a novel synthetic pathway in which cellulose is firstly tosylated using a …
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Kinetic and Thermodynamic Aspects of Voltage as a Driving Force for Ammonia Activation
… First, I look at an electrochemical analogue to reductive amination, where a carbonyl group is converted to an amine. Specifically, I demonstrate the electrochemical reductive amination reaction of benzaldehyde and ammonia and investigate its kinetics. I find that the reaction proceeds via an …
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New strategies for the synthesis and homologation of complex aliphatic amines
… of a second-generation carbonyl alkylative amination (CAA) reaction, mediated by zinc, is reported. The use of a metal-reductant-mediated mechanism provided the solution to many of the residual problems associated with the first-generation light-mediated CAA reaction, developed by the Gaunt …
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Tandem Cycloaddition Chemistry of Nitroalkenes: Total Synthesis of (+)-1-Epiaustraline and Synthesis of the Pentacyclic Core of (+/-)-Scandine
… centers. The final ring was created by reductive amination of a pyrrolidine aldehyde. This synthesis provided the core structure of (+/-)-scandine in 16 steps and 4.8% overall yield from 2,4-pentadienyl dimethyl malonate.
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The reductive animation of ethanol using supported metal catalysts
… and copper are efficient catalysts for the reductive amination of ethanol using ammonia. High selectivity to ethylamine product was obtained between reaction temperatures of 140 and 200°C, between ammonia to ethanol molar ratios ranging from 1 to 4 and between hydrogen to ethanol molar …
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Total synthesis of (-)-tantazole B. Total synthesis of (+,-)-FR900482
… of the 8-membered intermediate through reductive amination, stereospecific hydroxymethyla-tion and efficient oxidation of the amine to the hydroxylamine.
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Synthesis, antimalarial evaluation and structure-activity relationship in a series of dibenzlmethylamine (Dibemethin) derivatives of 4-amino-7-chloroquinoline
… using the Staudinger reduction of azides or the reductive amination via oxime of an aldehyde. Derivatives in which the para substituent on the terminal phenyl ring were altered from the parent compound (X = H) by replacement with Cl, OCH₃ orNMe₂ group were also synthesized. The choice of …
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Analysis of glycans and glycoproteins by mass spectrometry
… approach, glycans are usually derivatized using reductive amination to facilitate detection. An improved reductive amination procedure is introduced herein with less toxic reagents. In these experiments NaBH(OAc)3 was used as the reducing agent which is an alternative to the toxic, but …
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ESTUDOS VISANDO A SÍNTESE DE DIAMINAS DERIVADAS DE PINENOS COM POTENCIAIS ATIVIDADES NOS RECEPTORES NICOTÍNICOS DO SISTEMA NERVOSO CENTRAL
… ketones 1a,b. Later some unfruitful attempts of reductive amination had been carried through. So it had been produced the oximes 4a,b and 3a for latter attempts of reduction to obtain the amino compounds IIa,b and IVa that had shown unproductive and it will be better studied in the next future..
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The Application of the Titanium-Catalyzed Hydroamination of Alkynes toward the Synthesis of Benzylisoquinoline Derivatives
… 124 was obtained by intramolecular hydroamination of the aminoalkyne 123. Employing Noyori´s reduction protocol, the absolute configuration at C-1 of the benzylisoquinoline was introduced with 93% ee. Finally, methylation of norlaudanosine (146) by a reductive amination protocol afforded …
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A Diversity-Oriented Synthesis Approach to Functionalized Azaheterocycles using Cyclic Alpha-Halo Eneformamides
… metathesis, ring expansions, and intramolecular reductive amination. In this research, we present a step-economical, cost-effective, scalable, and diversity-oriented synthesis approach to highly functionalized N-heterocycles through the intermediacy of α-halo enamines/enamides. The synthetic …
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Developing New Methodologies for Crosslinked Polymeric Nanostructure Syntheses, Chemoselective Modifications, and Applications as Imaging and Delivery Agents
… fluorescent molecules through chemoselectively-reductive amination and were shown to display interesting in vitro cell association behaviors. The micelles were modified with near-infrared fluorescent dyes and crosslinked with diamino crosslinkers, each via reductive amination, to prepare robust …
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SÍNTESE DE NOVOS POTENCIAIS ANTAGONISTAS DO NMDA SUBTIPO NR2B DO SISTEMA NERVOSO CENTRAL BASEADOS EM CARBOXAMIDAS TRIAZÓLICAS
… (6). Once the reductive amination of 6 didn't produce the benzyl-(2-phenyl-2H- [1,2,3(triazole-4-ylmethyl)-amine (3), the preparation of this substance was investigated by the reduction of N-benzyl-2-phenyl-2H-1,2,3-triazole-4-carboxamide (7). Because the …
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Ribosomal Synthesis of N-methylated peptides
… acid and tagged with fluorous molecule through reductive amination.
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Development of synthetic routes towards bis (macrocyclic) compounds for imaging and therapy of cancer
… successfully coupled to a porphyrin compound via reductive amination and Buchwald-Hartwig coupling reactions, giving four new examples of porphyrin-cyclen conjugates.A Suzuki coupling methodology has been used to synthesise a porphyrin-cyclen conjugate with an aryl-aryl linkage which exhibits …
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DNA-catalyzed covalent modification of amino acid side chains in tethered and free peptide substrates
… the unexpected discovery of DNA-catalyzed reductive amination that may be applicable to site-specific labeling of nucleic acids. Finally, the thesis summarizes the optimization of the incubation conditions using click chemistry for direct free peptide selection. From these studies, we …
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Mono- and polynuclear Ferrocenyl-derived complexes: synthesis, characterisation and biological evaluation as antimycobacterial and antiplasmodial agents
… amino complexes were synthesised via reductive amination reactions from the (E)-4-vinylferrocenylbenzaldehyde. The imine moiety was hydrogenated in order to compare the effect on the biological activity. The imino and amino complexes were isolated in moderate to high yields. A second …
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Towards nuclear imaging with polynuclear radiotracers : the development of monomeric and dendritic scaffolds for radiometals
… or 2-picolylamino entities, via a single step reductive amination reaction. The monomeric and new dendritic ligands were comprehensively characterized using spectroscopic (1H NMR, 13C{1H} NMR, infrared) and analytical techniques (mass spectrometry and elemental analysis). Furthermore, the …
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