Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 130 for “"rafts"”.
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Lipid rafts in protein sorting and yeast cell polarity
… a sorting mechanism based on clustering of lipid rafts, dynamic membrane domains enriched in sphingolipids and sterols, could be an important part of the picture. My thesis study dealt with the elucidation of the molecular sorting principles at the TGN and their exploitation for cell surface …
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Lipid Rafts in Pancreatic Beta- and Alpha-cell Stimulus-secretion Coupling
… component of membrane microdomains, termed lipid rafts. Numerous signaling and transport proteins have been found to be targeted to lipid raft microdomains, where the function of the associated membrane proteins could be distinctly regulated. I have identified the expression of lipid raft …
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A Role For Lipid Rafts In Egfr Tki Resistance In Breast Cancer
… to discrete membrane microdomains (lipid rafts) in cell lines that are resistant to EGFR TKI-induced growth inhibition. Depletion of lipid rafts via cholesterol reduction results in sensitivity of EGFR TKI resistant breast cancer cell lines to the EGFR TKI gefitinib. Importantly, the …
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Molekulare Grundlage des Kongenitalen Nephrotischen Syndroms : Podocin rekrutiert Nephrin in Lipid Rafts
… für die Rekrutierung von Nephrin in Lipid Rafts. Im Gegensatz dazu waren die krankheitsverursachenden Podocin-Mutationen (R138Q und R138X) nicht in der Lage, Nephrin in Lipid Rafts zu rekrutieren. Dies lag entweder daran, dass die Mutation im Endoplasmatischen Retikulum zurückgehalten wurde …
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Numerical and physical modelling of piled rafts on soft clay under combined loading
… have investigated the behaviour of piled rafts under vertical load, with the objective of defining more rational and economic methods for their design. However, piled rafts are often used for structures that are subject to complex load, involving combinations of vertical, lateral, and …
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Die Regulation von humanen Natürlichen Killerzellen : regulierte SAP-Expression und die Rolle der Lipid Rafts
… spezielle Membranbereiche, die sog. Lipid Rafts, eine essentielle Rolle. NKG2D wurde nach Ligandenbindung in diese Membranbereiche rekrutiert. Nach biochemischer Zerstörung der Lipid Rafts war die NKG2D-vermittelte NK Zell Aktivierung blockiert. Es konnte gezeigt werden, dass inhibierende …
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The localization of UCH-L1(Ubiquitin C-terminaHydrolase-L1) in lipid rafts of neuronal cell
… instability and slowness of movement. Lipid rafts enriched glycosylphosphatidylinositol (GPI)-anchored proteins, glycosphingolipid and cholresterol, are specialized microdomains that play a role in endocytosis, exocytosis, signal transduction and receptor traffic king. The disruption of lipid …
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The regulation of yeast homotypic vacuole fusion and membrane trafficking events by sphingolipids, ergosterol, and lipid rafts
… Recent studies have shown that these lipid rafts contain an enrichment of many different proteins that function in essential activities such as nutrient transport, organelle contact, membrane trafficking, and homotypic fusion, suggesting that they are biologically relevant regions within the …
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Melanin-Concentrating Hormone Receptor-1 is Enriched in Lipid Rafts and the Effects of Lipid Raft Integrity on Receptor Signaling
… to demonstrate that MCHR-1 is enriched in lipid rafts and that a possible consequence of this may be altered signal transduction in obese individuals, such as downregulated ERK 1/2-mediated leptin transcription. Increased amounts of adipose tissue, and thus caveolae, may play a central role in …
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Investigating crosstalk in lipid rafts between the glucocorticoid receptor and gonadotropin-releasing hormone receptor signaling pathways in a gonadotrope cell line
… the co-localization of these receptors to lipid rafts, providing a specialized distinct region where the receptors can be in close proximity and reciprocally modulate each other’s signaling pathways.
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Understanding the Mechanism of Action of Rituximab in the Reversal of Multidrug Resistance in a Non-Hodgkins Lymphoma Cell Line
… a detergent-insoluble embrane compartment (lipid rafts). By redistributing CD20 into rafts, Rituximab(tm) (RTX) modified their stability and organization. P-glycoprotein (P-gp) is the constituent protein of MDR tumor cells and is responsible for pumping chemotherapeutic agents out of cells. …
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An analysis of Pre-Columbian balsa raft design to determine the suitability of such rafts for ancient maritime trade between Ecuador and Mexico
… their merchandise in large, ocean-going sailing rafts made of balsa logs. By about 700 CE the data show that Ecuadorian metalworking technology had reached the west coast of Mexico but remained absent in the intermediate region of Central America. Archaeologists have argued that this technology …
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IS BRAIN CHOLESTEROL THE MISSING CULPRIT IN DRUG ADDICTION?
… interactinG-proteins are localized in lipid rafts or non-lipid rafts in a receptor-dependent manner. Depletion of cholesterol disrupts certain GPCR function. This study investigates the effects of amphetamine (AMPH) self-administration on cholesterol content, lipid raft localization of Gα …
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Observations in Lipid Membrane Systems
… ordered (Lo) phase. The latter exists as small “rafts” of specific lipid composition containing a host of signaling proteins. Lipid raft theory links the aggregation of rafts to a signaling event. In its current iteration, the theory is incomplete, as it does not explain how rafts form and how …
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Oviposition Preferences for Infusion-Baited Traps and Seasonal Abundance of Culex Mosquitoes in Southwestern Virginia
… Cx. restuans and Cx. pipiens. In 2002, 1,345 egg rafts were collected from 5 traps set at different locations in the New River Valley (NRV). Cx. restuans constituted 93.2% of the catch; the remainder was Cx. pipiens (6.7%) and Cx. salinarius (<1%). In 2003, 4 ovitraps were placed at each of 6 …
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Biophysical and biochemical properties of the mammalian male germ cell specific sulfogalactosylglycerolipid (SGG): Contribution to the structure and zona pellucida affinity of pig sperm raft membranes
… in cell adhesion. Here, we demonstrated that rafts isolated from hypermotile capacitated pig sperm as low-density Triton X-100 insoluble membranes had the ability to bind specifically to homologous zonae pellucidae (ZP). This binding was dependent on pig ZP3alpha sulfoglycoprotein, a major …
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Oviposition Site Selection By Mosquitoes: Predator-Released Kairomones And Responses To Different Taxa
… metamorphose, and 4) they lay conspicuous egg rafts that allow direct assessment of oviposition. Certain mosquito species actively detect and avoid habitats with predaceous backswimmers (Heteroptera: Notonectidae), and certain species of fish, including Gambusia affinis. For my thesis I focused …
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Fluorescence resonance energy transfer-based subcellular visualization of FAK/Src activation by chemical and mechanical environment
… contains different microdomains called lipid rafts. In this thesis, specific Src/FAK biosensors based on fluorescence resonance energy transfer (FRET) were developed and further targeted to subcompartments of plasma membrane to visualize local Src/FAK signaling events in live cells with high …
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