Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"prostacyclin"”.
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Asymmetrische Totalsynthese des hochwirksamen Prostacyclin-Analogons Cicaprost
An asymmetric synthesis of cicaprost and a formal asymmetric synthesis of isocicaprost by a new strategy are described. The key steps of theses syntheses are the coupling of chiral bicyclic C6-C14 alkyne building blocks with a chiral C15-C20 omega-side chain Weinreb-amide building block at the …
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Prostacyclin-Inhalation in Kombination mit Almitrine zur Therapie des akuten Lungenversagens
… a possible additive effect of combined inhaled prostacycline and intravenous almitrine bismesylate (ALM) on pulmonary ventilation-perfusion ratio in acute lung injury (ALI) compared to inhaled prostacycline or intravenous ALM alone. Experimental ALI was established in all 24 pigs (weighing …
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The utilization of the prostacyclin analogue iloprost in the cryopreservation of stallion spermatozoa
… The current study evaluated the potential of the prostacyclin analogue as a protective additive to stallion semen during cryopreservation. Collections were taken from 12 stallions and divided into four samples, one to be designated as control and the other three to be exposed to various levels of …
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Mechanisims of prostacyclin-induced modulation of neuropeptide release from rat sensory neurons grown in culture
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Effect of Fatty Acid Modification on Prostacyclin Production in Cultured Human Endothelial Cells (Arachidonate, Elcosapentaenoate)
… acid (AA) and eicosapentaenoic acid (EPA) on prostacyclin synthesis. Supplemental levels of fatty acids (20-150 (mu)M) were supplied as sodium salts bound to bovine serum albumin (3:1 mole ratio) and added to M-199 with 20% fetal bovine serum. Both AA and EPA were readily incorporated into …
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Asymmetrische Synthese von 3-Oxa-15-Deoxy-16-(m-tolyl)-Tetranorisocarbacyclin und 15-Deoxy-16-(m-tolyl)-Tetranorisocarbacyclin
Some years ago besides the known prostacyclin receptor (IP1) a new prostacyclin-specific receptor (IP2) was discovered in the brains of different mammals. Both receptors show different binding-affinities towards stable prostacyclin-analogues. Prostacyclin-analogue …
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Asymmetrische Totalsynthese von 13,14-Dinor-inter-p-phenylencarbacyclin mittels konjugierter 1,4-Addition an ein Azoen
… of this thesis was the total synthesis of a new prostacyclin analog, a phenylogous carbacyclin. The target compound contains an arylic omega-side chain in opposite to the natural prostacyclin. A methodology should be found which would allow the attachment of the complete side chain in one single …
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The Role of Silicates in Interstitial Lung Disease
… or silica particles respectively. An increase in prostacyclin release after exposing endothelial cells to asbestos has been reported. This study attempts to elucidate the role of lung epithelial cells in the generation of asbestos induced ILD. A cell model to study crocidolite-induced toxicity was …
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The Role of Silicates in Interstitial Lung Disease
… or silica particles respectively. An increase in prostacyclin release after exposing endothelial cells to asbestos has been reported. This study attempts to elucidate the role of lung epithelial cells in the generation of asbestos induced ILD. A cell model to study crocidolite-induced toxicity was …
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The bone cement implantation syndrome - epidemiology, pathophysiology and prevention
… on RV performance. Comparing inhaled aerosolised prostacyclin with inhaled saline, the PVRI increased in both the saline (44%, p<0.001) and prostacyclin (36%, p=0.019) groups, with a less-pronounced increase in the prostacyclin group (p=0.031). The RVEF decreased significantly in both groups, with …
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Einfluß der endothelialen Autakoide NO und PGI2 auf die Permeabilität endothelialer Gap Junctions
… wirksame Gewebshormone (Autakoide, wie NO und Prostacyclin) die Durchlässigkeit der Gap Junctions beeinflussen. Hierzu wurde in konfluenten Kulturen von humanen umbilikalvenösen Endothelzellen (n=190) die Ausbreitung der Farbstoffe Carboxyfluoresein und Calcein nach Injektion in eine einzelne …
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ASPECTS OF FLUID THERAPY: An experimental study of the effects of systemic inflammation, microvascular permeability, blood pressure and plasma volume
… compared the ability of activated protein C and prostacyclin to counteract an increased protein leakage in septic inflammation. Plasma volume expanding capacity of currently used colloid solutions was evaluated in standardized models of hypovolaemia. Plasma volume was measured with a 125I-albumin …
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Psychological, cardiovascular and haematological aspects of the type A behaviour pattern in relation to coronary heart disease
… thromboxane A2 , and the anticoagulatory prostacyclin). Different response patterns emerged prior to, and following a mental arithmetic challenge. The task anticipation effect involved elevated heart rate, systolic and diastolic pressure, plasma adrenaline and prostacyclin. Type A's …
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Liposomal delivery of PDE5 inhibitors and UT-15C to human erythrocytes
… PVR with the administration of drugs such as prostacyclin or its analogs and phosphodiesterase 5 (PDE5) inhibitors. These medications can be used alone or in combination and may have serious unwanted side effects that are additive when used in combination.</p><p>Here an alternative drug …
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The Influence of Dietary Fat on The Cerebral Microvasculature: Compositional, Prostaglandin Synthetic, and Permeability Studies
… of phospholipids, prostaglandin F(,2(alpha)) and prostacyclin synthesis by cortical slices and microvessels, respectively, kinetic parameters of adenosine uptake, and the potential involvement of eicosanoids in the uptake process.
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On Brain Oedema
… study III, it was shown that post treatment with prostacyclin in experimental meningitis reduces systemic plasma volume loss, and may diminish the rise in intracranial pressure. In study IV, the effect of statin treatment after brain trauma in rats was investigated. No effect on brain oedema, …
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Einfluss von Iloprost, einem stabilen Prostazyklin-Analogon, auf die myokardiale Kontraktilität im Vergleich zu natürlichem Prostazyklin : Laborexperimentelle Untersuchung an humanem Herzgewebe und Gewebe aus Kaninchenherzen
Iloprost, a stable derivate of prostacyclin (epoprostenol), is known to diminish PVR. In addition, improvement of right ventricular function has been observed after inhaled administration. Direct inotropic actions are not studied until now. In the present experimental study the dose-dependent …
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Antiplatelet and antihypertensive actions of ridogrel
… thromboxane B2 synthesis without affecting renal prostacyclin synthesis. Blood pressure was reduced despite an increase in plasma renin activity. The pressor response to the TP receptor agonist U46,619 was shifted to the right following ridogrel pre-treatment, confirming competitive TP receptor …
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1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine (Platelet Activating Factor): Interactions with Sheep Platelets
… <p>Modulators of platelet activation such as prostacyclin, TMB-8 and indomethacin, had similar effects on the magnitude of response by aggregation and SCP assay. Both ATP release and SCP were inhibited in proportion to the concentration of prostacyclin. Neither aggregation nor SCP was affected …
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Effects of iloprost on embryo development in vitro
… been reported that Iloprost, a biosynthetic prostacyclin analogue and cardiovascular active drug, enhances embryo development and prevents apoptosis. It is hypothesized that the mechanism involves the induction of the survivin pathway. In this study, growth patterns of mouse embryos in four …
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