Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 337 for “"predisposition"”.
-
Molecular genetic investigations of renal cell carcinoma predisposition
… in nature, a proportion are due to genetic predisposition caused by syndromic and non-syndromic conditions. Inherited renal cell carcinoma is associated with alterations in genes such as VHL, MET, FH, and FLCN and identification of these genes has been critical to understanding the molecular …
-
Identification of Familial Wilms Tumor Predisposition Genes Using Whole Genome Sequencing
… have a family history of Wilms tumor. Familial predisposition is inherited in an autosomal dominant manner and demonstrates incomplete penetrance, estimated to be 30%.</p> <p>Whole genome sequencing of eleven individuals in three Wilms tumor families was performed to identify the gene(s) …
-
Examining Stage Theories and the Predisposition to Lead within the Homosexual Community
An application of homosexual stage-based self-integration theory suggests that until gay individuals have become fully self-integrated, their capacity for leadership within the community is diminished. Unfortunately, now more than ever before, leadership is needed in dealing with such pressing …
-
Stress Predisposition of Woody Plants to Stem Canker Caused by Botryosphaeria Dothidea
Made available in DSpace on 2014-12-14T04:37:47Z (GMT). No. of bitstreams: 1 8004302.pdf: 2304081 bytes, checksum: 6d1611ea0a7703a31360543a2547d1af (MD5) Previous issue date: 1979
-
Impaired awareness of hypoglycaemia in type 1 diabetes. Prevalence, genetic predisposition and mortality
Contains fulltext : 183427.pdf (Publisher’s version ) (Open Access)
-
Assessing the impact of non-coding mutations on breast cancer risk predisposition genes
… a HBOC of unknown genetic cause), whose genetic predispositions are poorly understood. Indeed, the cause of between 50-60% of HBCs currently remains unknown, demonstrating the missing heritability of the disease. Furthermore, the role of mutations/variants in regulatory gene regions are not well …
-
The roles of multiple infectious agents in the predisposition of turkeys to colibacillosis
… infectious agents are responsible for the predisposition of turkeys to colibacillosis. These agents were first identified as potential contributors through field case studies. They include hemorrhagic enteritis (HE) virus, Newcastle disease virus, and Bordetella avium. Further retrospective …
-
The Impact of Predisposition Towards Group Work on Intention to Use a CSCW System
… First, this research contributed to how a user's predisposition toward group work affects their acceptance of CSCW technology. Second, it helped identify ways to overcome some of the obstacles associated with group work and the use of CSCW technology in an academic online environment. Finally, it …
-
Exploring cancer predisposition in individuals with multiple primary cancers germline- and tumor genomic profiling
Contains fulltext : 320401.pdf (Publisher’s version ) (Open Access)
-
The use of whole exome sequencing data to identify candidate genes involved in cancer and benign tumour predisposition
… sequencing has transformed the study of disease predisposition. The sequencing of both large disease sets and smaller rare disease families enables the identification of new predisposition variants and potentially provide clinical insight into disease management. There is no standard protocol for …
-
An investigation of DNA sequence variants in genes that regulate collagen fibrillogenesis and predisposition to musculoskeletal soft tissue injuries
The aim of this dissertation was to use a case-control genetic study to investigate the association of polymorphisms within the COL5A1, MIR608, COL11A1 and COL11A2, genes with AT and/or ACL injuries in Caucasian populations. These aims were explored in three studies: i) Determine whether the COL5A1 …
-
A pathway-based approach investigating DNA sequence variants to implicate the inflammatory pathway in the predisposition to Achilles tendinopathy
The aims of this dissertation were therefore (i) to follow a pathway-based approach investigating genes encoding proteins involved in the ECM degradation and apoptosis signalling cascade for associations with AT and (ii) to identify a polygenic risk model, comprised of several genetic markers …
-
SARCOPENIA, LIVER AND CARDIOVASCULAR ALTERATIONS IN A MULTICENTRIC COHORT OF PATIENTS WITH MASLD: EVALUATION OF CLINICAL PRESENTATION AND GENETIC PREDISPOSITION
… and oxidative stress. Additionally, genetic predisposition plays a role in MASLD, with specific polymorphisms in PNPLA3, TM6SF2, MBOAT7, and GCKR promoting severe liver disease, while the HSD17B13 variant appears protective against MASLD. Despite this background, most studies evaluating the …
-
Which fairness factors most influence minority professionals to remain committed to an organization as evidenced by a predisposition to depart
The presence of minority professionals in the workforce ranks is indicative of the organization's corporate citizenship and its commitment to equal opportunity and diversity. Consequently, factors that affect organizational commitment and retention are of key importance. This mixed study explored …
-
The influences of atmospheric nitrates and annual climatic variables in predisposition to winter desiccation injury in Fraser fir and red spruce
The occurrence of winter injury in red spruce (<u>Picea rubens</u>) L. sarg. and Fraser fir (<u>Abies fraseri</u>) pursh. poir. in relation to the level of atmospheric nitrates and climatic parameters of precipitation and temperatures was investigated. Data and foliage samples were collected from …
-
Saying ‘No’: A biographical analysis of the experiences of women with a genetic predisposition to developing breast/ovarian cancer who reject risk reducing surgery
Background: Genetic technologies have identified some of the genes implicated in cancer susceptibility. Women with mutations in breast/ovarian cancer-susceptibility genes (BRCA1 and 2) have a lifetime combined risk of breast/ovarian cancer of more than 80%. Risk reducing surgery (RRS) reduces …
-
Investigating the genomic distribution and potential contribution of retrotransposable elements in relation to their potential impact on genome function and predisposition to human diseases.
… to their potential impact on genome function and predisposition to human diseases. Randa Aweis Ali Active retrotransposable elements (RTEs) provide a continuous source of genomic diversity in humans. The potential impact of a novel RTE insertion depends on its genomic location. Previous studies …
Page 1 of 17