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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 451 for “"polypeptide"”.
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Spektroskopische Strukturanalytik synthetischer Polypeptide
… der Sekundärstruktur von synthetischen Polypeptiden eingesetzt. Dabei wurden die Struktur-Funktions-Beziehungen der dritten extrazellulären Schleife des Gonadotropin-freisetzenden Rezeptors (GnRH-R) untersucht. Die spektroskopischen Ergebnisse belegten, dass die zuvor getroffene Aussage …
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Membrane fragmentation by a 20-29 fragment of human islet amyloid polypeptide and rat amyloid polypeptide
… cells. The amyloidogenic human Islet Amyloid Polypeptide (hIAPP, also known as human amylin) is believed to play a crucial role in this biological process. Previous studies have shown that hIAPP forms small aggregates that kill β-cells by disrupting the cellular membrane. In this study we …
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Leukocyte Response to Elastin-Like Polypeptide Coatings
… models. Biomaterial coatings of elastin-like polypeptides (ELPs) recombinantly produced in the Woodhouse laboratory showed reduced fibrinogen adsorption, platelet adhesion, and platelet activity. However, the reason for their relative non-thrombogenicity is still not fully understood. In this …
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Structure Study of a Polypeptide Antibiotic, Antiamoebin
Made available in DSpace on 2014-12-13T20:10:41Z (GMT). No. of bitstreams: 1 7915396.pdf: 5116182 bytes, checksum: 45d154d8df16644136c5d9e5e8d72714 (MD5) Previous issue date: 1979
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Synthetic polypeptide-based hydrogel systems for biomaterials
Hydrogels formed from synthetic polypeptides generated by ring opening polymerization (ROP) of a-amino acid N-carboxyanhydrides (NCAs) present a robust material for modeling the interaction between extracellular matrix (ECM) properties and cellular phenomena. The unique properties of the …
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Polypeptide (dis)assembly in bacterial spores and microalgae
… Chapter 1 introduces the thesis starting with polypeptide properties and classifications, looking at methods of determining protein structure and their importance in the properties of bacterial spores. The aims and objectives of the thesis are contextualised with a literature review, …
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Organometallic Palladium Reagents for Polypeptide Bioconjugation and Macrocyclization
… selective N-arylation of p-aminophenylalanine in polypeptides with pre-formed palladium oxidative addition complexes is described. The depressed pKa of the aniline NH2 group enables chemoselective C−N bond formation on peptides containing multiple other aliphatic amino groups at lysines or the …
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Detection of Polypeptide Interactions Via Periodate Triggered Dopa Crosslinking
Protein-Protein interactions mediate most biological function, yet elucidation of the molecular architecture within a cell still remains a formidable challenge for molecular biologist. We have developed a novel, bioorthogonal cross-linking chemistry based upon periodate mediated oxidation of the …
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Silica Polypeptide-Based Colloids: Physical Properties and Novel Materials
The investigation of polypeptide composite particles, PCPs, is described. The production of mesoporous and polycolloid architectures is also addressed. PCPs were prepared by both growing form and grafting to method. They consist of a core made of silica, silica-coated magnetite or silica-coated …
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Synthesis and Surface Characterization of Silica-Polypeptide Composite Particles
… sequential surface characterization of silica-polypeptide composite particles is described. Nearly monodisperse colloidal silica cores were obtained by the alkaline hydrolysis of tetraethyl orthosilicate (TEOS). The hydrodynamic radius can be easily controlled in the range of ƒî 20-140 nm by …
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Understanding Elastin-Like Polypeptide Block Copolymer Self-assembly Behavior
<p>Elastin-like polypeptides (ELPs) are thermally responsive polymers composed of the pentapeptide repeat Valine-Proline-Glycine-X-Glycine where X is any amino acid except proline. ELP diblocks have been engineered by creating two ELP blocks with hydrophilic and hydrophobic guest residues. The …
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Pituitary adenylate cyclase-activating polypeptide regulates excessive alcohol consumption
… for the pituitary adenylate cyclase-activating polypeptide receptor 1 (PAC1), the cognate receptor for the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP), blocks excessive alcohol drinking as well as motivation to drink. On the other hand, the PAC1 antagonist does not …
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Functionalized polypeptide- and lipid-based nanoparticles - synthesis and applications
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01
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The helical configuration of the polypeptide chains in collagen
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1954.
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Endophytes as source of polypeptide and polyketide antibiotics fengycin and bacillaene
Endophytic bacteria, which populate plant tissues, can influence physiological processes in plants. They also have antagonistic effects against many phytopathogens. Utilization of these bacteria as a biological agent for protection of plants is an environmentally friendly alternative to chemical …
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Structure and Mechanism of PCAT1, a Polypeptide Processing and Secretion Transporter
<p>ATP-binding cassette (ABC) transporters utilize the energy from ATP to transport substrates across biological membranes. Various ABC transporters perform diverse biological functions across all forms of life ranging from importing essential nutrients to exporting toxic drugs (Ford and Beis 2019; …
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Studies on aspects of the physiology and pathophysiology of pancreatic polypeptide
Pancreatic polypeptide (PP) is a 36 amino-acid residue peptide which has recently been recognised in pancreatic endocrine cells. Although PP has a number of effects on gastrointestinal and pancreatic exocrine function, its physiological function has not been clarified. Studies were undertaken to …
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The roles of vasoactive intestinal polypeptide in circadian entrainment of suprachiasmatic nucleus
… coherent daily rhythms. Vasoactive intestinal polypeptide: VIP), a neuropeptide produced by SCN neurons, plays a major role in synchronizing SCN neurons to each other. Whether VIP mediates synchrony to environmental cues and how synchrony within the SCN is achieved has not been examined …
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Lamina assoziierte Polypeptide 2, Lamin-B-Rezeptor und Lamine : Untersuchungen an Vertebratenmodellen
Der Zellkern ist ein wichtiges Organell von eukaryotischen Zellen, der durch eine Doppelmembran vom Cytoplasma abgetrennt wird. Mit Hilfe des Zebrafischs als Modellorganismus und kultivierten Zellen verschiedener Vertebraten wurde in mehreren Teilprojekten Untersuchungen an integralen (Lamina …
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