Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 28 for “"polyketides"”.
-
Studies Towards The Novel Synthesis Of Benzoisochromane Quinone Polyketides
Granaticin is a structurally unique member of the benzoisochromane quinone (BIQ) family of antibiotics. The molecule and its derivative exhibit a sugar moiety fusted to the naphthazarin core, only exhibited by one other natural compound, by a C-C glycosidic bond and an aldol like bond. The …
-
Type III Polyketide Synthases: Discovery, Characterization, and Engineering
The polyketides are a diverse group of natural products with important applications in medicine and industry. Industry, especially the pharmaceutical industry, is under pressure to deliver "greener" chemical syntheses that are less environmentally damaging and incorporate renewable resources. There …
-
Uncovering the Biosynthesis of Natural Products Using Fourier-Transform Mass Spectrometry
… enzymes employed in the biosynthesis of polyketides (PK) and nonribosomal peptides (NRP). In this work, FTMS is used both in the discovery of novel natural products as well as in the characterization of novel enzymology.
-
STRUCTURE DETERMINATION, BIOCHEMICAL CHARACTERIZATION, AND PROTEIN ENGINEERING OF THE ACYL CARRIER PROTEIN DOMAIN FROM 6-DEOXYERYTHRONOLIDE B SYNTHASE
Polyketides are an important class of natural products. 6-Deoxyerythronolide B Synthase (DEBS) is a type 1 polyketide synthase that produces the Polyketide antibiotic drug erythromycin. DEBS is a large multi-domain enzyme complex containing multiple enzymatic domains, including acyl carrier protein …
-
Studies towards the syntheses of the citreamicins
… natural products (PXNPs) are a family of polyketides which are characterized by their highly oxygenated, angular hexacyclic frameworks and a diverse range of biological activities. The dissertation research described herein has been focused on the syntheses of the citreamicins, a subset of …
-
Donor-Acceptor Cyclobutanes and Their Application for Heterocycle Synthesis and Progress Towards Biselide A
… catalyst was used in the progress towards the polyketides natural product biselide A. Key reactions for the formation of a single diastereomer of an advanced stage intermediate included: Evans’ asymmetric aldol and a Prasad reduction to form a 1,3-syn diol exclusively which cyclized with …
-
Enantioselective Total Synthesis of the Kibdelones
The kibdelones are a family of aromatic polyketides reported in 2006 by Capon and co-workers. These compounds possess potent antibiotic and cytotoxic activities and operate via an unknown and potentially unique mode of action. In order to fully investigate these properties the kibdelones were …
-
SYNTHESIS OF NATURAL-DERIVED POLYPHENOLS AS POTENTIAL ANTICANCER AGENTS
… of secondary metabolites include isoprenoids, polyketides, alkaloids, non ribosomial peptides and polyphenols, these latter directly derived from shikimate pathway, as phenylpropanoids and lignans, or from a mixed biosynthetic pathway (shikimate/ acetate and/or malonate pathways), as …
-
Synthesis and Biosynthesis of Polyketide Natural Products
… have been confined to the biosynthesis of polyketides, a therapeutically and structurally diverse class of natural products, where we employed both synthetic chemistry and biochemical techniques to validate complex metabolic processes. One such example pertained to the uncertainty …
-
The Development of Cyclobutenone, and Other Work
… guide the route toward dalesconol A and B. These polyketides are potent immunosuppressants. A common synthetic strategy unifies these total syntheses, much as the cyclobutenone program is comprised of three related projects.
-
Discovering novel natural products from bioactive plants and bacteria
… One group of valuable natural products is polyketides, which are known to be antiviral, antibacterial, and anticancer. In my first project, I attempted to develop an efficient strategy for cloning and characterizing Type III PKS genes that are likely responsible for the synthesis of novel …
-
Cyclization modes in type III polyketide synthases and the synthetic compounds used as probes for mechanistic studies.
… of linear polyketide intermediates to produce polyketides with distinct ring structures. The mechanisms of pyrone and resorcinol ring formation in type III PKSs remain unknown, despite many years of research on this family of enzymes. Compounds, thought to be intermediates in these enzyme …
-
Synthetic Study Of Karlotoxins And Investigation Of Alpha-Diaminoboryl Carbanion Chemistry
… sense, karlotoxins are a family of linear polyketides with three distinctive regions; a bis-tetrahydropyran core fragment, a long, highly oxygenated carbon chain, and a lipophilic chlorodiene unit. Such potent biological activities as well as novel molecular complexity engaged our interest …
-
Functional Analysis of Secondary Metabolite Biosynthesis-Related Genes in Alternaria brassicicola
… that small molecule nonribosomal peptides and polyketides in A. brassicicola play diverse, but also fundamental, roles in fungal development and pathogenesis.
-
Investigating intermediates in 6-methylsalicylic acid biosynthesis
… acid (6-MSA) is one of the oldest known polyketides. It is synthesised in vivo by the polyketide synthase 6-methylsalicylic acid synthase (6-MSAS), a multifunctional enzyme which uses its active sites iteratively. The stereochemistry of the hydroxyl produced from the single ketoreduction, …
-
Nucleophilic Carbon-Carbon Bond-Forming Reactions of 2-Methylenetetrahydropyrans
… components of many biologically active polyketides and natural products.</p> <p>The use of exocyclic enol ethers as nucleophiles was first demonstrated as a general process in three-component coupling reactions with secondary nucleophiles. The 2-β-hydroxy tetrahydropyran products were …
-
DESIGN, SYNTHESIS, AND OPTIMIZATION OF SMALL-MOLECULE CD4 MIMETICS AS HIV-1 ENTRY INHIBITORS AND SYNTHETIC EFFORTS TOWARD THE TOTAL SYNTHESIS OF NAHUOIC ACID Cii
… Part II: The Nahuoic acids are polyhydroxylated polyketides defined by a cis-decalin core fused to a highly oxygenated polyol side chain. First isolated from marine Streptomyces strains, these metabolites attracted significant attention as the only natural products reported to selectively and …
-
Isolation and structure elucidation of bioactive secondary metabolites from marine sponges and sponge-derived fungi
… aerizusa afforded seven structurally related polyketides, including two new twelve-membered macrolides: pandangolide 3 and 4, and a new acetyl congener of the previously isolated 5-hydroxymethyl-2-furoic acid. The two furoic acid analogues isolated were found to be responsible for the …
Page 1 of 2