Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"polyglycine"”.
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Conjugate gradient density matrix search: A linear scaling alternative to diagonalization
… time with diagonalization is demonstrated for polyglycine chains containing up to 493 atoms and water clusters up to 900 atoms.
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The variation of the gas phase acidity of a cysteine residue in oligopeptides
… than di-peptides, and the acidities of cysteine-polyglycine peptides were close to those of the cysteine-polyalanine analogues.</p><p>Computational studies were performed through conformer search, geometry optimization, and energy calculations using the Spartan and the Gaussian suite of programs. …
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Inhibiting Protein-Protein Interactions using Rationally-designed Repeat Proteins
… loop of CTPRs, with the introduction of polyglycine residues either side of the grafted peptide being shown to lead to a greater than two-fold improvement in the binding affinity. In Chapter 6, it was shown that the functionalised CTPRs could be successfully delivered into HCT 116 by …
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Male Subfertility and Prostate Cancer Risk: Epidemiological and Genetic Studies
… of variable length; the polyglutamine and polyglycine stretches, respectively. Variation in CAG repeat length had been associated with a number of andrological disorders, whereas very little was known about the GGN repeat when the work for this thesis was started. We hypothesized that …
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Development and Application of Mass Spectrometry Based Methodologies to Study Ubiquitin-Like Modifiers
… achieved through a novel method exploiting the polyglycine specificity of the bacterial protease- transpeptidase Sortase A (SrtA). Using a mutant with increased catalytic activity, SrtA mediates biotinylation of diglycine tryptic remnants, and also acts as a specific protease for release of …
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Synthesis and mass spectrometry studies of oligopeptides
… N- and C- terminal glutamic acid polyalanine and polyglycine (EA<sub>n</sub>, A<sub>n</sub>E (n=2,3); EG<sub>n</sub> (n=2,3), G<sub>n</sub>E (n=2-4)) and cysteine polyalanine (CA<sub>n</sub>, A<sub>n</sub>C (n=4-6)) peptides were studied. Primarily, EA<sub>n</sub> and EG<sub>n</sub> peptides …
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Novel Poly(N-substituted glycine)s : synthesis, post-modification, and physical properties
Various synthetic approaches were explored towards the preparation of poly(N-substituted glycine) homo/co-polymers (a.k.a. polypeptoids). In particular, monomers that would facilitate in the preparation of bio-relevant polymers via either chain- or step-growth polymerization were targeted. A 3-step …