Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 40 for “"polycation"”.
-
Structure-Property-Transfection Relationships in Polycation-mediated Non-viral DNA Delivery
… structure-transfection relationships involved in polycation-mediated gene delivery. Efforts focused on the influence of molecular weight, macromolecular topology, carbohydrate modifications, and charge density on the overall transfection activity in vitro. Several families of polycations were …
-
Modulation of Dendritic Cells with the Interleukin-10 Gene on Polycation-Modified Polymeric Particles
… In this work, we investigated the ability of polycation-modified polymeric particles complexed with interleukin-10 (IL-10) gene to modulate DCs. The delivery systems (designated as PSO10H6 and PLGAO10H6) were formed by coating cationic peptide O10H6 (O: ornithine; H: histidine) on the …
-
Polycation-polyanion complexes : preparation and properties of poly(vinylbenzyl-trimethyl ammonium)-poly(styrene sulfonate)
Thesis (Sc. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1961.
-
Mixed ion and electron conducting polymer composite membranes for artificial photosynthesis
… of crosslinked poly(vinyl alcohol) (PVA) and a polycation miscible with PVA. It is analogous to aqueous strong base solution. The polycation is a OH- containing polymer; PVA solvates this polycation and facilitates the ion conduction via Grotthuss mechanism. The membrane with proper composition …
-
Complexation Between DNA and Hydrophilic-Cationic Diblock Copolymers
DNA-polycation complexes (polyplexes) are gene delivery vehicles that offer a number of advantages over viral vehicles: high genetic payload capacity, low toxicity, and low cost. Among the many polycation architectures, hydrophilic-cationic diblock copolymers are particularly promising due to their …
-
Nonlinear Optically Active Ionically Self-Assembled Monolayer Thin Films of Organic Polymers Intercalated with an Inorganic Hectorite, Laponite RD
… studies are presented of thin films containing a polycation, a nonlinear optically (NLO) active chromophore, and a synthetic hectorite that self-assemble into the noncentrosymmetric structure required for second order nonlinear optical responses. UV/Vis spectroscopy and ellipsometry were used as …
-
Nonlinear Optical Properties and Structural Characteristics of Ionically Self-Assembled Nanoscale Polymer Films Influenced by Ionic Concentration and Incorporation of Monomer Chromophores
… of the polymer chromophore with the subsequent polycation layer, and random orientation of the chromophores within the bulk of each polyanion layer. A reduction in film thickness accompanied by an increase in net polar ordering is one possible avenue to obtain the second-order nonlinear optical …
-
ENGINEERING LIPID AND HYBRID NANOVECTORS FOR TARGETED GENE DELIVERY TO MACROPHAGE SUBPOPULATIONS
… when genetic materials are complexed with a polycation or a lipid, followed by the addition of a lipid or a polymer to ameliorate the cellular toxicity, modulate cellular uptake and/or improve the transfection efficiency of the resulting nanovectors (Chapter 1). The experimental part of this …
-
Antiviral polymeric drugs and surface coatings
… PEIbased (PEI = polyethylenimine) hydrophobic polycations against both enveloped and nonenveloped viruses. When solutions containing herpes simplex viruses (both 1 and 2) were brought in contact with NN-dodecyl,methyl-PEI coated on either polyethylene slides or latex condoms, they could be …
-
New polymeric biomaterial interfaces for biosensor applications
… Poly(allylamine)-g-poly(ethylene glycol) polycation graft-copolymers were designed, synthesized, and characterized in order to combine bio-functionality with patternability on charged polyelectrolyte multilayer surfaces. Polymer-on-polymer stamping (POPS) techniques were used to create …
-
Characterization of Intermolecular Interactions in Nanostructured Materials
… included self-assembly of surfactant micelles, polycation complexation of DNA, and temperature-dependent hydrogen bonding in polymeric systems. ITC was successfully used to determine the low critical micelle concentration (CMC) for a novel gemini surfactant with limited water solubility. CMCs …
-
Insights into the Mechanisms of Metal Oxide and Cationic Antimicrobials
… insight on the mechanisms of metal oxide and polycationic disinfectants. The first part of this work presents the development and study of antimicrobial facemasks that kill 99.9% of pathogenic bacteria responsible for hospital acquired infections, Staphylococcus aureus, Pseudomonas aeruginosa, …
-
Polyelectrolyte nanostructures formed in the moving contact line: fabrication, characterization and application
… contact line approach aligned one-dimensional polycation structures were fabricated and these structures were used as templates for assembling amphiphile molecules. Quasiperiodic aligned and oriented nanostructures of polyelectrolyte molecules formed in moving droplets were utilized for …
-
Second-Order Nonlinear Optical Characteristics of Nanoscale Self-Assembled Multilayer Organic Films
… of the polymer chromophore with the subsequent polycation layer, and random orientation of the chromophores within the bulk of each polyanion layer. A reduction in film thickness accompanied by an increase in net polar ordering is one possible avenue to obtain the second-order susceptibility …
-
Improving blood compatibility of surfaces using tanfloc and carboxymethyl-kappa-carrageenan polyelectrolyte multilayers
… an amphoteric antimicrobial polymer, as both a polycation and polyanion. These PEMs showed strong antibacterial activity and excellent biocompatibility, providing a foundation for multifunctional coatings. The second aim investigates the hemocompatibility of TAN and …
-
Micelles and Interpolyelectrolyte Complexes formed by Polyisobutylene-block-Poly([meth]acrylic acid) - Synthesis of Polymers and Characterization in Aqueous Solutions
… driven process. Upon addition of the polycation to the micellar PIB-b-PMAA solution, first an increase in turbidity of the solution can be observed. In this kinetically driven regime, large assemblies of micelles are formed. With time, these aggregates are equilibrating toward the …
-
Studies of modified pumice and titanomagnetite filtration media
… natural TM by treatment with aluminium and iron polycation solutions were unsuccessful. Greater success was achieved in the modification of the properties of SS by treatment with aluminium and iron polycation solutions and mixtures of these solutions. IEPs ranging from the 4.10 ± 0.06 of acid …
-
Next generation of electrospun textiles for chemical and biological protection and air filtration
… can decompose OP nerve agents, and antimicrobial polycation, poly (N-vinylguanidine), were synthesized and LbL-assembled onto electrospun fibers to achieve multifunctional coatings. The capability of these functionalized fabrics to detoxify representative chemical and biological toxic agents and …
-
Studying and controlling chromophore orientation in polyelectrolyte layer-by-layer thin films
… to assembly films. For example, a polyanion and polycation are dissolved in separate aqueous solutions at a given pH and salt concentration. A charged substrate is immersed into one solution, rinsed with water, and immersed in the other solution. This cycle is repeated to assemble films. …
-
Non-viral drug delivery systems for immune modulation
… to the cell membrane, endosomes and nucleus. Polycation surface-modification seemed broadly extendable to a biodegradable polymer particle delivery system for siRNA. Cationic lipids or lipidoids were promising polycations to apply to biodegradable particle surface-modification because they …
Page 1 of 2