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Showing 1 to 20 of 58 for “"poly(D"”.
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Freisetzungsverhalten von unterschiedlich hydrophil/hydrophoben Modellsubstanzen aus Poly-(D,L-lactid)- und Poly-(D,L-lactid)-co-PEO-co-poly-(D,L-lactid)-Mikrosphären und pharmazeutische Anwendungen
… model substances and drugs from degradable poly-(D,L-lactide) (PDLLA) and poly-(D,L-lactide)-co-PEO-co-poly-(D,L-lactide) (ABA) microspheres as well as poly-(D,L-lactide-co-TMC)(90:10) nanospheres in PBS-buffer are characterised. To investigate the release behaviour, three different …
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Synthesis of Higher Molecular Weight Poly(D-glucaramides) and Poly(aldaramides) as Novel Gel Forming Agents
<p>Poly(alkylene D-glucaramides) with higher molecular weights than previously reported were prepared through a multi-step process beginning with 1:1 alkylenediammonium D-glucarate salts. These salts set a precise stoichiometric equivalence between co-monomers, a necessary requirement for higher …
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Synthesis of Higher Molecular Weight Poly(D-glucaramides) and Poly(aldaramides) as Novel Gel Forming Agents
<p>Poly(alkylene D-glucaramides) with higher molecular weights than previously reported were prepared through a multi-step process beginning with 1:1 alkylenediammonium D-glucarate salts. These salts set a precise stoichiometric equivalence between co-monomers, a necessary requirement for higher …
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Entwicklung eines Systems für die kontrollierte Wirkstofffreisetzung aus biodegradierbarem Poly-D,L-Lactid zur Restenoseprävention im kardiovaskulären Bereich
… allows to integrate thermolabile substances in poly-D,L-lactid. By bioabsorption the agents are released in the body as a kind of a drug-delivery-system.The growth factor VEGF which is specific for endothelial cells shall reduce the proliferation of the smooth muscle cells by promoting the …
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Study of poly (l-lactic acid)/poly (d-lactic acid) stereocomplex as nucleating agent for poly (l- lactic acid) crystallization
Poly (lactic acid) (PLA) is a biodegradable polymer with good renewability and processability. However, it has some drawbacks. The Poly (lactic acid) (PLA) stereocomplex formed via the interaction between optical isomers Poly (L-lactic acid) (PLLA) and Poly (D-lactic acid) (PDLA), provides …
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Entwicklung einer biodegradierbaren Harnleiterschiene : In-vitro-Analytik von Poly(D,L-Lactid) als Homo- und Copolymer, Formgebungs-Technologie, Oberflächenmodifizierung und tierexperimentelle Untersuchung im Schaf-Modell
… a biodegradable ureteric stent, various polylactides were analyzed and grafted with a clinically adapted surface. Stent moulding was performed by CESP-technology (Controlled Expansion of Saturated Polymers), which is not based on high temperature but gas-loading under high pressure which …
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Preparation and Characterization of Electrospun Poly(D, L-Lactide-Co-Glycolide) Scaffolds for Vascular Tissue Engineering and the Advancement of an In Vitro Blood Brain Barrier Model
… Tissue Engineering laboratory at the California Polytechnic State University, San Luis Obispo is currently in the process of developing a dynamic <em>in vitro</em> blood brain barrier model that will implement an in-house fabricated electrospun PLGA scaffold pressure sodded with C6 glial cells …
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Topologically constrained DNA intercalators: Synthesis and DNA binding studies
… 31 dissociates 10 to 40 times slower from poly(d(A-T)) $\sb2$ and poly(d(G-C)) $\sb2$ than its analogous mono-linked analogue, spermine diacridine (7). $\sp1$H NMR studies of 31 complexed to d(CGCG)$\sb2$ indicate that the macrocycle binds to DNA by formation of a catenated complex in which …
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Studien zur kontrollierten Freisetzung biologisch aktiver Substanzen aus resorbierbaren Nano- und Mikrosphären
… endocyosis. Commercially available poly(D,L-lactide) (RESOMER R 208) and poly(D,L-lactide-co-glycolide) 50:50 (RESOMER RG 504) were used as materials, both of which have a history of biomedical applications. The controlled release of bioactive substances in scaffolds for the tissue …
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3D scaffolds for tissue engineering produced by microfabrication technology
… using an in-house built microfabrication system. Poly(D,L-lactic acid) (PDLA), poly(D,L-lactic-co-glycolic acid) (PLGA) and chitosan scaffolds presenting homogeneously distributed 100 Âμm size pores were fabricated. Fabrication consisted in a layer by layer deposition of filaments of PDLA and …
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Induktion und Prophylaxe Implantat assoziierter Knocheninfektionen am Modell eines antiinfektiv beschichteten Marknagels
… stable, antibacterial gentamicin-loaded poly-(D,L-lactide) (PDLLA) coating of orthopedic devices. In vitro, elution kinetics of gentamicin and furthermore, biocompatibility and effectiveness in preventing implant-related osteomyelitis should be studied in vivo. Coating of commercial steel …
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Lamination of a biodegradable polymeric microchip
This work builds on the initial design of a polymer microchip for controlled-release drug delivery. Currently, the microchip employs a nonbiodegradable sealant layer, and the new design aims to fabricate it only of biodegradable parts. Experiments were conducted to evaluate two potential designs …
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Development of particle-based systems for the delivery of oligonucleotides into primary dendritic cells
… system consisting of carboxylate-modified polystyrene microspheres (MS) coated with a short cationic peptide (O10H6) was shown to effectively deliver ODN to DCs. The MS serves to stabilize O10H6 and ODN complexation and remains a colloidal dispersion upon addition of condensates. …
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Coaxial double-walled microspheres for drug and gene delivery applications
Polymeric double-walled microspheres were developed by coaxial electrohydrodynamic atomization (CEHDA) and precision particle fabrication (PPF) techniques. Here, we focus on double-walled microspheres consisting of a poly(D,L-lactic-co-glycolic acid) (PLGA) core surrounded by a poly(D,L-lactic …
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Poly(ethyl glyoxylate) Solid-Core Particles for Drug Delivery
The ability to trigger the degradation of polymeric nanoparticles (NPs) by a specific stimulus can provide a method of improved drug targeting and selective release capabilities in vivo. The challenge for most polymeric drug delivery systems remains the necessity for many stimuli events to trigger …
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The Efficacy of Overlapping Method Using Absorbable Copolymer in Reconstruction of Infero-medial Orbital Wall Fractures with Bony Strut Loss
… by overlapping method using Resorb X® plates (poly(D,L)-Lactic acid). METHODS: To repair infero-medial orbital wall fractures with loss of bony strut, we bent the medial aspect of plate for floor fracture according to the anatomical structure and then we inserted the floor implant as which was …
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Explaining Black-Box Classifiers by Implicitly Learning Decision Trees
… both. Our certification algorithm runs in time poly(d, C(f)) and outputs a certificate of size poly(C(f)), where C(f) is the “average certificate complexity" of f. Our counterfactual algorithm runs in time S(f)^[O(∆f (x))] ·log d, where S(f) is the sensitivity of f (a discrete analogue of the …
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Langzeituntersuchung zur In-Stent-Restenose eines neuen biodegradierbaren, wirkstoffbeladenen, intravaskulären Polylaktidstents nach Implantation in porcine Koronararterien
… of a new biodegradable paclitaxel-loaded polylactide stent. Due to high rates of instent restenosis and permanent nature of metal stent implants, synthetic polymers have been proposed as surrogate materials for stents and local delivery systems for drugs. Paclitaxel was shown to inhibit …
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