Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"perforant path"”.
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Influence of perforant path synaptic excitation on the initiation of hippocampal sharp-wave ripple activity in vitro
… inputs, cortical input to the HC conveyed by perforant path (PP) may influence SWR initiation nevertheless. Still, direct evidence that PP synaptic excitation can elicit SWRs is lacking, and it is unclear how this influence might compete or interact with self-organizing mechanisms. This …
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From space to episodes : modeling memory formation in the hippocampal-neocortical system
… patterns on CA3, and recurrent collaterals and perforant path inputs are subject to graded Hebbian plasticity. Attractors are thus sculpted in CA3, and are associated with entorhinal activity patterns. In familiar environments, place fields are controlled by the way that perforant path inputs …
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NOVEL DOPAMINERGIC SIGNALING MODULATING HIPPOCAMPAL SYNAPTIC TRANSMISSION
… affects excitatory synaptic transmission in perforant path synapses onto dentate gyrus granule cells and whether such effects differ from those at area CA1 synapses. I found that SKF38393 produced a concentration-dependent increase in field excitatory postsynaptic potential (fEPSP) in both …
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Leptin induces a novel form of long-term potentiation at the direct cortical input to hippocampal CA1 synapses
… cells where they receive direct cortical input (perforant path) from the entorhinal cortex. Indeed, mounting evidence demonstrates that the direct cortical input is of importance to spatial learning and memory. Here we show that application of leptin induced a novel form of long-term potentiation …
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Morphological Correlates Of Synaptic Plasticity After Long Term Potentiation In The Rat Hippocampus
… induction of long-term potentiation (LTP) of the perforant path, although few studies have investigated such parameters in the maintenance phase of L-LTP. Moreover, the results of investigations of synaptic and neuronal morphometry changes after LTP have varied and this could be due to the methods …
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Stress and Hippocampal Plasticity
… the synaptic response in the dentate gyrus after perforant path stimulation. Contextual fear conditioning was also shown to temporarily decrease cell proliferation in the dentate gyrus. Taken together, the results suggest that the hippocampus is capable of responding to an animal's experiences …
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Rate alterable traumatic brain injury device for rodent models
… be important in understanding the differences in pathology associated with these impacts. In this study a novel modular computer controlled device capable of inducing controlled TBI is designed. To achieve maximum control and sensitivity, a closed loop voice coil control device is utilized, to …
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Immunological investigations into synaptic plasticity
… time-points following tetanisation of the right perforant path. 24hrs following tetanisation (but not at earlier time-points), the titre of R14 was elevated in the dentate area ipsilateral to tetanisation and in both the ipsi- and contralateral CAL The titre of 411B was increased specifically in …
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Mnemonic Representations of Transient Stimuli and Temporal Sequences in the Rodent Dentate Gyrus In Vitro
… gyrus. In response to brief stimulation of the perforant path, semilunar granule cells exhibit intrinsic plateau depolarizations driven by NMDAR and L- and T-type voltage-dependent calcium channel conductances, driving persistent synaptic barrages onto hilar cells. These barrages last for 10s of …
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Structural and functional heterogeneity of cells in the rat hippocampus
… neurons that provide a significant output pathway from the hippocampus. DG granule neurons are the primary signal receivers from the major input pathway through the Perforant Path (PP) from the entorhinal cortex (EC). These neurons send their dendrites into the molecular layer of the …
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CELLULAR ALTERATIONS OF ADULT HIPPOCAMPAL NEUROGENESIS IN THE FGF14−/− MOUSE MODEL
… remains elusive. Identifying factors, pathways, and molecules that affect multiple stages of adult neurogenesis not only would shed light on the pathogenesis of several brain illnesses but also may improve the treatment strategies against these diseases. Using a combination of BrdU …
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Akt signal transduction dysfunction in the 3xTg-AD mouse model of Alzheimer's disease
… and environmental factors are also involved. The pathological characteristics of AD include extracellular deposition of the beta-amyloid peptide (Aβ) and intraneuronal accumulation of neurofibrillary tangles (NFTs) made of aggregated paired helical filaments (PHFs) of the hyperphosphorylated tau …
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Regenerationsfähigkeit entorhino-hippocampaler Fasern in organotypischen Schnittkulturen
Die vorliegende Arbeit beschäftigt sich mit der altersabhängigen Abnahme der Regenerationsfähigkeit im ZNS und stellt ein Kultursystem vor, mit dem man effizient pharmakologische Substanzen auf regenerationsfördernde Effekte testen kann. Entorhino-hippocampale Schnittkulturen ermöglichen als in …