Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"perfluorocarbon"”.
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Monitoring and assessment of aqueous/perfluorocarbon fermentation systems
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1989.
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Laser-activated perfluorocarbon nanodroplets as a tool in neurological applications
Perfluorocarbon nanodroplets (PFCnDs) are an emerging class of nanoagents for biomedical applications. These nanoparticles are unique in their ability to phase change from liquid nanodroplet to gas microbubble when activated by electromagnetic energy. The ability of PFCnDs to phase change when …
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Molecular dynamics simulation of linear perfluorocarbon and hydrocarbon liquid-vapor interfaces
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1999.
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Investigation of Histotripsy Cavitation and Acoustic Droplet Vaporization From Perfluorocarbon Nanoparticles
… Nanoparticle-mediated histotripsy (NMH) uses perfluorocarbon-filled nanoparticles to create bubble clouds at lower pressures than that of the intrinsic threshold of histotripsy. Prior studies have shown that nanodroplets (NDs) and nanocone clusters (NCCs) both reduce the cavitation threshold, …
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Influence of Oxygenated Perfluorocarbon (oxyPFC) on survival and free radical production of Ischemic Cardiomyocytes
In the late 1980’s, several animal studies showed that oxyPFC given intravenously or via intracoronary route have the potential to reduce the size of myocardial infarctions. The exact mechanism by which this reduction occurred remained unclear until today. The subject of this experimental work was …
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Thrombin-Inhibiting Perfluorocarbon Nanoparticles: A New Class of Therapeutic for Acute Thrombosis Treatment and Diagnosis
… eventual disintegration of the thrombus.</p><p>Perfluorocarbon nanoparticles were functionalized by covalent addition of PPACK or bivalirudin to carboxy-PEG capped lipid components to the stabilizing lipids. Over 10000 inhibitors were added per particle. In vitro experiments evaluated inhibition …
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Determination of the Structural and Functional Mechanisms of Perfluorocarbon-based Nanoemulsion Particle Interactions with Model Biomembrane Systems
Perfluorocarbon based nanoemulsion particles: PFC-NEPs) are very small sized: ~ 250 nm in diameter) greasy droplets that are enclosed by emulsifying phospholipid monolayer. PFC-NEPs have been extensively developed for target-specific delivery of therapeutic agents such as imaging agents and drug …
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Design and Qualification of a Coded Aperture Cycloidal Mass Spectrometer to Detect Perfluorocarbon Tracer Molecules for Environmental Applications
… One leak location method exists utilizing perfluorocarbon (PFC) tracer molecules and a mobile gas chromatograph. This instrument is sensitive enough to detect the atmospheric background levels of PFC in the ppqv (parts per quadrillion by volume, 10-12) range; however, this instrument is …
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Molecular self assembly in flurocarbon surfactant / water systems
… showed phase behaviour uncharacteristic of ionic perfluorocarbon surfactant systems in that they exhibit a clouding phenomenon with increasing temperature. This behaviour was ascribed to the tight association of the large, hydrophobic counterions with the poiar head group region. In this study a …
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Development of Potential Remote Coal Mine Fire Response Measures: Use of Multiple Passive Source Tracers and Simulation of High Expansion Foam Flow in Simulated Gob Material
… testing of the passive release rates for three Perfluorocarbon tracer compounds over a 180-day period. The results of this study demonstrate the ability for the permeation plug release vessel design to release Perfluorocarbon tracers at a steady rate. Current response methods for a fire in a …
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Physicochemical characterization of PEG-based comb-like amphiphilic copolymer structures for possible imaging and therapeutic applications
… solutions of polymer structure containing perfluorocarbon blocks were characterized by 19F magnetic resonance spectroscopy to evaluate their application for MRI contrast enhancement. Perfluorocarbon-containing comb copolymers (i.e., PEG-PFC) in solution had a low CMC of about 2 [mu]m. They …
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Absolute Quantitation for MR Molecular Imaging of Angiogenesis
… integrin-targeted perfluorocarbon (PFC) nanoparticle (NP) emulsions. Unfortunately, the radiological world is realizing that although image quality may be consistently high, the absolute quantitative values being calculated vary widely across time, techniques, …
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Graphene at interfaces
… Meisenheimer complexes reactions of hydrocarbon, perfluorocarbon and water-soluble alkyl amines on the surface of graphene at room temperature. This approach opens the door to a rich variety of functional single layer graphenes for applications.
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The effects of chemical pressurization on screen electrode fuel cells
… to increase the reactant concentration. Perfluorocarbons (PFC), currently being used in biomedical applications as oxygen carriers in plasma, can be used to effectively raise the cathode oxygen concentration. This thesis will propose a model of perfluorocarbon emulsions as applied to an …
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In vitro evaluation of cytotoxicity and cellular uptake of alternating copolymers for use as drug delivery vehicles
… developed to attach ligands (for targeting), perfluorocarbons (19F MR imaging), fluorescent dyes (NIRF imaging), and radioiodine (nuclear imaging and radioimmunotherapy) to the backbone. Attachment of hydrocarbon or perfluorocarbon sidechains provides amphiphilicity to produce the multimodal …
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Eliminating oxygen supply limitations for transplanted microencapsulated islets in the treatment of type 1 diabetes
… The first method involves incorporating a perfluorocarbon emulsion into alginate microcapsules to enhance oxygen permeability in order to protect islets from hypoxia. The second method involves dispersing the islets into single cells and allowing them to reaggregate into cell clusters …
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Development and Evaluation of a Permeation Plug Release Vessel (PPRV) for the Release of Perfluoromethylcyclohexane (PMCH) in Underground Mine Tracer Gas Studies
… in HVAC studies to SF6 as a tracer are perfluorocarbon tracers (PFT). Many PFTs exist as volatile liquids at room temperature and pressure. This characteristic prevents a PFT from being released using the same technique as SF6. This paper introduces a passive release method for PMCH. …
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Luminescent organic materials and their application in solar technologies
… an LSC that utilizes a deoxygenated liquid perfluorocarbon (PFC) as the host for a strongly fluorescent perfluoroalkylated thieno[3,4-b]pyrazine between two slabs of PMMA. In the event the luminophore photodegrades after prolonged exposure to sunlight, the luminescent layer can be easily …
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Nanoscale Enhancement of Photosensitized Radionuclide Stimulated Therapy
… Finally, we develop a polymer stabilized perfluorocarbon nanoemulsion able to be tracked with near-infrared fluorescent imaging and increase the oxygenation of hypoxic tumor tissue for the duration of PRaST. This can help to both boost ROS generation and normalize tumor microenvironments. …
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Bio-artificial liver support system : an evaluation of models used in demonstrating or improving metabolic and clinical efficacy
… bioreactor perfused with blood plasma, and a perfluorocarbon oxygen carrier which replaces hemoglobin. There are also novel design properties in the circulation system itself. Demonstrating the metabolic and clinical efficacy of a BAL device requires implementing, in vitro (cell biology), in …
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