Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"p75"”.
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Contribution of LEDGF/p75 to Prostate Cancer Chemoresistance
… lens epithelium derived growth factor p75 (LEDGF/p75) in HRPC resistance to DTX. Our studies show that LEDGF/p75 overexpression attenuates DTX-induced lysosomal destabilization and cell death in a cellular model of HRPC, implicating this stress protein in DTX resistance <em>in virto. …
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The Potential Role of LEDGF/p75 in Prostate Cancer
… to the lens epithelial-derived growth factor p75 (LEDGF/p75). LEDGF/p75 is a survival protein that confers resistance to stress-induced cell death. Autoantibodies targeting LEDGF/p75 were detected in 18.4% (38/206) of prostate cancer sera, as opposed to only 4.5% (9/199) in sera from matched …
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Signaltransduktion des Neurotrophinrezeptors p75 durch die Zinkfingerproteine NRIF1 und NRIF2
Der Neurotrophinrezeptor p75 wurde als erstes Mitglied der Tumornekrosefaktor-Rezeptor-Superfamilie kloniert. Da die trophischen Eigenschaften der Neurotrophine durch eine zweite Klasse von Rezeptoren, die Trk-Rezeptor-Tyrosinkinasen, vermittelt werden, wurde p75 lange als deren „Corezeptor“ …
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Targeting LEDGF/p75 to Sensitize Chemoresistant Prostate Cancer Cells to Taxanes
… Lens epithelium-derived growth factor p75 (LEDGF/p75) is a stressresponse protein that promotes cellular survival against environmental stressors, including oxidative stress, radiation, and cytotoxic drugs. It is overexpressed in PCa and other cancers and has been associated with …
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Biochemical and Functional characterization of the LEDGF/p75-MeCP2 Interaction in Tumor Cells
The lens epithelial derived growth factor p75 (LEDGF/p75) is a novel pro-survival and stress-inducible transcription co-activator that protects mammalian cells from various environmental stresses such as oxidative stress, heat shock, and serum starvation. This emerging cancer-related protein is …
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The role of nerve growth factor and p75 neurotrophin receptor in recovery from liver fibrosis
… nerve growth factor-mediated apoptosis through p75 neurotrophin receptor ligation. Hepatic myofibroblast apoptosis is critical to resolution of liver fibrosis. I show that human hepatic myofibroblasts exhibit differential responses to mature and pro-nerve growth factor/p75 neurotrophin …
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The Role of the p75 Neurotrophin Receptor in Experimental Inflammation of the Central Nervous System
… Rolle des niedrigaffinen Neurotrophinrezeptors p75NTR in Bezug auf axonale Schädigung in der experimentellen autoimmunen Encephalitomyelitis (EAE) gezeigt. Nach EAE Induktion per aktiver Immunisierung mit dem Myelin-Oligodendrozyten-Glykoprotein-Peptid MOG35-55 zeigten p75NTR KO Mäuse einen …
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Characterizing interactions between the cellular HIV-1 integration cofactor, LEDGF/p75 with chromatin and HIV-1 integrase
… cellular lens epithelium-derived growth factor/p75 (LEDGF/p75), as well as cellular LEDGF/p75 and chromatin. All three interactions could present novel drug targets and were the focus of my studies throughout my dissertation research. By understanding these critical interactions between the …
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Investigation of p75 neurotrophin receptor and the role of its post-translational modifications in tumour cell motility and invasiveness
The p75 neurotrophin receptor (p75NTR) is a member of the tumour necrosis factor superfamily, which relies on the recruitment of cytosolic protein partners - including the TNF receptor associated factor 6 (TRAF6) E3 ubiquitin ligase - to produce cellular responses such as apoptosis, survival, and …
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Mitochondrial Instability, Lack of Erk1/2 Activation and High Expression of P75NTR in Engrailed-Deficient Mesencephalic Dopaminergic Neurons
… deficiency results in increased expression of P75 neurotrophin receptor, which is causal to death of the neurons. The death of Engrailed double mutant mesDA neurons, as a direct result of high expression of P75, can be inhibited by application of TrkB/C-specific neurotrophins, BDNF, NT4 or NT3, …
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Transcriptional and Translational Products of Avian Erythroblastosis and Avian Myeloblastosis Viruses
… contain a 75,000 Dalton gag-related polyprotein (p75) which contains the p19 region of the gag gene at its amino terminus. Two-dimensional tryptic peptide mapping indicated that p75 contained novel peptides in addition to those derived from p19. p75 was found to be a phosphoprotein containing a …
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Neurotrophins and neurotrophin receptors in adult primary sensory neurons
… neurotrophins in the PNS. Lastly, the role of p75 in sensory neurons was examined by conducting a detailed analysis of DRG in p75 knock-out mice. Compared to wildtype controls, p75 knock-out mice show diminished NGF binding affinity, reduced retrograde transport of low quantities of NGF and a …
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The Role of Glucocorticoid Signaling in Prostate Cancer Health Disparities
… Lens Epithelium-Derived Growth Factor p75 (LEDGF/p75) and Clusterin (CLU). Results revealed a robust pattern of GR-induced upregulation of LEDGF/p75 and CLU in African-American (AA) PCa cells compared to European-American (EA) PCa cells. We also detected increased GR transcript …
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Untersuchung der lokalen und systemischen Immunantwort nach intravesikaler BCG-Behandlung des oberflächlichen Harnblasenkarzinoms
… allen Plasma- und Urinproben die Spiegel des TNF-p75-Rezeptors (TNF-p75-R) bestimmt. <br>Ergebnisse: Der Vergleich der ex vivo Zytokin-Produktion der Leukozyten in den Vollblutkultutren der Patienten aus Gruppe I erbrachte keine Veränderungen der Zytokinspiegel, abgesehen von etwas verminderten …
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A cytological study of a triploid x diploid cross of Sorghum vulgare
Call number: LD2668 .T4 1955 P75
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A cytological study of a triploid x diploid cross of Sorghum vulgare
Call number: LD2668 .T4 1955 P75
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Testosterone’s regulation of the HPA axis differs for adolescent and adult male rats
… 1, I replicated the results for P45 and P75 male rats. In Experiment 2, rats were gonadectomised (GDX) and given implants of testosterone, dihydrotestosterone (DHT), or empty, control implants (CTL) and plasma was obtained after 30 minutes of restraint. Although no significant differences …
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The Effects Of Oxidative Stress On P75ntr Signaling In Dopaminergic Neurons
<p>The p75 neurotrophin receptor (p75NTR) is responsible for implementing cellular death during embryonic development and in response to cellular injury. The receptor has been recognized as a contributor of neurodegeneration in numerous pathological conditions. Cleavage of p75NTR by Tumor Necrosis …
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Combined mechanical loading of composite tubes
… Subsequently, experiments were performed on P75/934 graphite/epoxy tubes with a stacking sequence of [15/1/ ± 10/0/-15], using pure torsion and combined axial/torsional loading. The in-plane material properties needed for incorporation into the analytical model were determined using tests on …
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Interactions of Thyroid Hormones, Nerve Growth Factor and Its Receptors in Development and Plasticity of the Rat Olfactory Bulb
… bulb NGF, while up-regulating NGF receptors, p75$\sp{\rm NTR}$ and trkA in the glomerular region. We propose that decreased bulbar NGF results in decreased trophic support for specific NGF responsive cells, leading to compensatory up-regulation of NGF receptors which compete for the limited …
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