Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 171 for “"osteoblasts"”.
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Cellular Responses to Short-Term Mechanical Loading: Relative Involvement of Osteoblasts, Pre-Osteoblasts, and Osteoprogenitor Cells
… calcium content, or total cell number of the osteoblasts within each colony. Loading protocols sufficient to induce woven bone formation stimulated periosteal preosteoblasts to proliferate within 36 h after load application, and contribute new osteoblasts to the adaptive response within 48 h. …
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Characterization of estrogen receptor alpha in mouse osteoblasts
… the two cell types operating bone homeostasis, osteoblasts and osteoclasts. Estrogens effects are entirely mediated by two nuclear receptors, Estrogen Receptor (ER) alpha and ER beta. ERs are ligand induced transcription factors, which upon estrogen binding activate the transcription target …
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Age-related proliferative behavior of mandibular osteoblasts : an in vitro study
… occurring in the proliferative behavior of osteoblasts is a necessity for orthodontists because the performance of an orthodontic tooth movement requires a sufficient remodeling ability of the affected bony tissue. This could be affected by several local and systemic factors which influence …
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The osteogenic effects of zirconia and titanium surfaces on human osteoblasts
… the biological responses of normal human osteoblasts cultured on titanium and zirconia surfaces, focusing on key cellular events including attachment, proliferation, alkaline phosphatase (ALP) activity, and osteocalcin expression over a 21-day period. Quantitative analysis revealed that …
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Progesterone Regulation of Insulin like-Growth Factor : Binding Protein-5 Gene Transcription in Human Osteoblasts
… binding protein-5 (IGFBP-5) is produced by osteoblasts and potentiates IGF mitogenic actions in osteoblast cultures. Progesterone (PG) increases osteoblast proliferation and increases osteoblast IGFBP-5 expression. Mechanisms underlying PG induction of IGFI3P-5 expression were investigated …
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Signaling mechanisms that suppress the anabolic response of osteoblasts and osteocytes to fluid shear stress
… Additionally, mechanical stimulation of osteoblasts and osteocytes by fluid shear stress further enhanced expression of osteocalcin when Src activity was inhibited. Importantly, fluid shear stress stimulated an increase in nuclear Src activation and activity. The mechanism by which Src …
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Optimization of culture conditions for equine bone marrow mesenchymal stem cells and their differentiation into osteoblasts
<p>The horse industry is a multibillion dollar industry where the health of the animals is of great focus for horse owners. Bone fractures are an aspect of equine health failure that is continually catastrophic and often fatal. In addition to discussing fracture, this review will outline the …
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The Fruit of Poncirius Trifoliata Promotes Mesenchymal Stem Cell Differentiation into Osteoblasts in Glucocorticoid-induced Osteoporosis Model
… mesenchymal stem cell differentiation into osteoblasts in DEX-treated C3H10T1/2 cells. It was tested that whether DEX inhibited Runx2 expression through smurf1 expression in C3H10T1/2 cells. DEX induced Runx2 degradation through enhancement of smurf1 expression in the levels of mRNA and …
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The Molecular Mechanisms of Estrogen Receptor α on Two Single Nucleotide Polymorphisms to Regulate WNT Signaling in Osteoblasts
… of these SNPs has remained unknown. Analysis of osteoblasts from 112 different joint replacement patients reveals that the genotype of rs2887571 correlates with WNT5B expression, and the genotype of rs9921222 correlates with AXIN1 expression. Mechanistically, SNP rs2887571 has less binding of ERα …
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Isolation of Mesenchymal Stem Cells Derived from Adult Bone Marrow and Umbilical Cord Blood and Their Potential to Differentiate into Osteoblasts
… to differentiate into mature, bone producing osteoblasts. The results of the studies showed that our novel isolation method allowed proliferation of a homogeneous MSC population. Our irnrnunodepleted MSCs were 99% double positive for antibodies CD44 and CD105 which are highly specific for …
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INHIBITED MINERALIZATION IN OSTEOBLASTS CULTURED UNDER VARIED SIMULATED PARTIAL GRAVITY CONDITIONS AND THE USE OF PHYTONUTRIENTS FOR MITIGATING THE EFFECTS OF REDUCED GRAVITY
… on the physiology and morphology of cultured osteoblasts were investigated, specifically on their proliferation, osteogenic differentiation, and matrix mineralization. In assessing the role of mechanotransduction in microgravity-induced cytoskeletal dysfunction, this thesis also explored …
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Organosilicate nanoparticles as gene delivery vehicles for bone cells
… also characterized in order to ensure that the osteoblasts retained their phenotype. The expression of various proteins involved in bone formation, such as alkaline phosphatase, osteocalcin, osteopontin and fibronectin was quantified. The results indicated that osteoblasts retained their …
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조골세포 사멸 및 분화에서 GSK3b의 역할
" Dfferentiation of osteoblasts is critically involved in bone formation and requires several signal pathways. One of the important pathways is the Wnt signaling where GSK3 plays a key role in regulation of β-catenin activity, a major effector, through phosphorylation. Glucocorticoids (GCs) are …
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Characterizing slc8a4b as an Osteoblast Marker in Danio rerio
… 8 member 4b (slc8a4b) is an emerging marker for osteoblasts in zebrafish, enabling further study of healthy bone development, bone regeneration, and skeletal diseases. To guide future use of slc8a4b as an osteoblast marker, this study aims to identify which osteoblast functions slc8a4b expression …
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Factors affecting bone cell growth and differentiation under differing culture conditions
Marrow stromal cell (MSC) differentiation into osteoblasts is an important part of the bone growth and remodeling process. This process can be exploited to help solve the problem of bone wound healing. Because of problems with bone grafts, implantation of biodegradable 3D scaffolds seeded with MSCs …
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The Hematopoietic Compartment Regulates Osteoblast Differentiation And Apoptosis During Cytokine Treatment
… signaling, we unexpectedly uncovered a role for osteoblasts in regulating cytokine-induced mobilization. By isolating and sorting different fractions of bone marrow stromal cells we demonstrate that osteoblasts represent a major source of CXCL12 in the bone marrow. In addition, both the number …
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