Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"optical biosensor"”.
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High-Throughput Screening Development Using Photonic-Crystal Optical Biosensor
Protein-DNA interactions are essential for fundamental cellular processes such as transcription, DNA damage repair, and apoptosis. As such, small molecule disruptors of these interactions could be powerful tools for investigation of these biological processes, and such compounds would have great …
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A systematic study of ion-induced nanopatterning on photonic crystal-based label-free optical biosensor
Photonic crystal (PC)-based biosensors are promising candidates for label-based fluorescence and label-free optical biosensors. This is due to the presence of PC, a periodically-structured dielectric material with diffraction gratings engineered on the surface that can control light propagation …
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Advances in high-throughput screening: better compounds, novel targets, enhanced sensors
… screening libraries. Chapter 3 will describe an optical biosensor-based assay for inhibitors of the RNA-protein binding interaction responsible for type 1 myotonic dystrophy (DM1), a hereditary degenerative disorder. Finally, Chapter 4 will explore the limits of small-molecule detection in a …
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A spectroscopic smartphone biosensor for use in point-of-care diagnostic applications
… A custom cradle was developed to maintain optical alignment allowing for the diffraction, and therefore spectrometric analysis, of light transmitted either directly through a sample or via an intermediary optical biosensor. Demonstration of the instrument is provided with both an …
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External cavity laser label-free biosensor
… laser, we demonstrate a new type of label-free optical biosensor that achieves a high quality factor through the process of stimulated emission, while at the same time providing high sensitivity, large dynamic range and simple detection instrumentation. The photonic crystal is fabricated …
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Development of a fluorescence resonance energy transfer optical nanoscale biosensor based on a liquid-core waveguide platform
… a self-contained and robust fluorescent optical biosensor architecture utilizing fluorescence resonance energy transfer (FRET) is proposed. This biosensor architecture is then applied to a highly adept liquid-core waveguide platform. FRET is a distance-dependent signal transduction method …
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Antibody-based biosensor assays for the detection of zilpaterol and markers for prostate cancer
… the Biacore (a surface plasmon resonance-based optical biosensor capable of monitoring biomolecular interactions in 'real-time'). A zilpaterol-HSA conjugate was used to generate and characterise single chain antibody fragments. A combinatorial single chain (scFv) antibody phage display library …
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Numerical characterisation of label free optical biosensors
… methods to simulate advance and complex optical biosensor structures. Finite Element Method (FEM) has been established as one of the most powerful and versatile numerical method and has been implemented in this thesis to characterize, analyse and optimise label-free optical biosensors for …
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A photonic crystal biosensor application for assessment of iron deficiency
… nanoparticles (IONs) and a photonic crystal (PC) optical biosensor as an immunodiagnostic platform for detection of serum ferritin and soluble transferrin receptor (sTfR), biomarkers for iron deficiency, is presented. Two assay formats were explored in this research: 1) standard sandwich assay …
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External cavity laser biosensor for label-free detection
Optical label-free biosensors serve as a powerful detection tool to analyze biomolecular interactions, and have been widely used in pharmaceutical drug discovery and biochemical sensing. Desirable performance metrics for such sensors include high sensitivity and fine resolution, which are essential …
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Subwavelength nanostructures for optical biosensing and rapid photochemical reactions
… illumination. Second, 3D nanostructures for optical biosensing have been investigated. We demonstrate optical spectroscopy by using subwavelength dielectric nanostructures as the substrate material for localized surface plasmon resonance metallic nanoparticles. Nanostructured substrates made …
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Bioimaging with photonic crystal enhanced microscopy
… guided-mode resonances and providing local optical modes, can enhance the light-matter interaction on its surface and thus used for label-free detection and biosensing. One dimensional photonic crystal surfaces are designed and utilized as a biosensor, and further integrated with an ordinary …
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Design, fabrication and characterization of resonant waveguide grating based optical biosensors
… home based point-of-care diagnostics. Label-free optical biosensing with high sensitivity, throughput, compactness, and low cost, plays an important role to resolve these diagnostic challenges and pushes the detection limit down to single molecule. Optical nanostructures, specifically the resonant …