Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"neuroprotective effect"”.
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Neuroprotective effect of mesenchymal stem cells in neurodegenerative disease : focusing on Parkinsonian disease
… and neurons. MSCs have been also known to pose neuroprotective effects through secreting various cytotrophic factors. Based on our previous studies demonstrating neuroprotective effect of hMSCs in Parkinson’s disease, we extended our investigations into other parkinsonian disease in addition to …
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Neuroprotective Effect of Human Mesenchymal Stem Cell on Dopaminergic Neurons by Anti-inflammatory Action
… of PD. The present study was to evaluate effect of human bone marrow-derived mesenchymal stem cell (hMSCs) on modulation of neuroinflammation. We used lipopolysaccharide (LPS)-induced in vitro and in vivo inflammation models to investigate whether hMSCs have a protective effect on the …
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Newly Synthesized Pyroglutamate Amide and its Neuroprotective Effect Against Neurotoxicity Induced Cell Death in Alzheimer's Disease
… neurotoxicity. Amides play a major role as neuroprotective group in medicinally important compounds not only because they are particularly stable, but also because they are polar (they contain regions of high positive and negative electrical charge density), which allows amide-containing …
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A network analysis based proteomic and transcriptomic investigation into HIV-Tat induced neuronal dysfunction and the neuroprotective effect of lithium
HIV-associated neurocognitive disorders (HAND) affect up to 70% of HIV positive individuals and are the leading cause of dementia in patients under 40 years. Despite this, the molecular mechanisms involved in the onset of HAND are not well understood. Among a number of plausible etiological agents …
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The induction of long-term potentiation attenuates kainic acid-induced excitotoxicity
… stimulation (LFS) has no incremental effect on the degree of cell death resulting from exposure to KA, (3) the blockade of NR2B-containing NMDARs using Ro25-6981 attenuates KA-induced neurodegeneration while the blockade of NR2A-containing NMDARs using NVP-AAM077 does not influence …
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Cholinesterase Inhibitors and Neuropathology of Cerebrovascular Disease and Other Dementias in Patients with Alzheimer’s Disease: A Study of NACC Autopsy and Medical History Data, 2005 – 2017
… cholinesterase inhibitors suggested protective effects against neuronal toxicity from multiple sources. Investigations in primates found ChEI restored cerebral blood flow. Work in animals suggests ChEI may have a neuroprotective effect, though not necessarily impacting pathologies associated …
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Non-canonical Activation of CREB/crh-1 Mediates Neuroprotection in a <i>Caenorhabditis elegans</i> Model of Excitotoxic Necrosis
… in brain ischemia, can also activate neuroprotective pathways. A frequently suggested neuroprotective cascade involves the activation of the transcription factor CREB by its phosphorylation, but on its own this mode of CREB activation is promiscuous. We aim to elucidate the specific …
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Effects of Cigarette Smoking on Neurocognitive Performance in Dementia Patients
… increasing incidence rate and the lack of effective treatments that cure or slow disease progression, and thus. prevention is crucial. Some studies suggests that cigarette smoking may increase the risk of developing dementia, but others suggest that smoking may have a neuroprotective …
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Early life immune and physical stress directly influences anxiety-like behaviour in adolescent rats: examining sex differences
This thesis examined the effects of neonatal acute immune activation with the endotoxin, lipopolysaccharide (LPS) on postnatal days 3 and 5 on adolescent anxiety-like behaviour in rats before and after a stress period. Previous research has shown that adults rats exposed to LPS during the neonatal …
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Transient receptor potential vanilloid 1 exhibits neuroprotective effects in LPS-induced dopaminergic neuronal death in the suabstantia nigra in vivo.
… potential vanilloid subtype 1 (TRPV1) leads to neuroprotective effects by anti-inflammtory action. The main purpose of this thesis is to investigate the functional effects of capsaicin (CAP), the TRPV1 agonist, in LPS-induced in vivo PD model. To do that, we investigated the LPS-induced …
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Exploring the influence of adipokines on neuronal function in Alzheimer’s disease
… The current study was focused on the potential neuroprotective effect of adipokines on the neurons during hydrogen peroxide (H2O2) induced oxidative stress and cell death. In this study, human neuroblastoma SHSY5Y cells were differentiated using retinoic acid to demonstrate neuronal-like …
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The pathological role of acrolein in experimental autoimmune encephalomyelitis and multiple sclerosis
… sequestering of acrolein afforded a neuroprotective effect by suppressing tissue acrolein level, slowing disease progression, and decreasing symptom severity. Acrolein can also be produced exogenously as a pollutant from combustion engine exhaust, industrial processing, burning of …
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Cellular and Circuit Level Responses to Neural Stem Cell Transplantation in the Rodent Cortex
… to exert both neurotrophic and immunomodulatory effects in pathological contexts, but grafted cells frequently remain undifferentiated. The specific interactions between undifferentiated NSCs and the normal host microenvironment are not well understood. To investigate the functional impact of …
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Neuroimmune Interactions of Enteric Neurons and Mast Cells: Friends or Foes?
… but was found to counteract the VIP-induced neuroprotective effect. We also showed that the mast cell-induced increase in cell death of cultured myenteric neurons was not executed via CRF signaling pathways. In conclusion: I/R in rat large intestine attracted mast cells to invade the muscle …
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NEUROPROTECTIVE STUDIES ON THE MPTP AND SOD1 MOUSE MODELS OF NEURODEGENERATIVE DISEASES
… treatment for one neurologic disease may also be effective for several other neurodegenerative disorders. There is growing awareness that due to the complexity of pathophysiological processes in human disease, specifically targeting or inactivating a single degenerative process or a discrete …
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An investigation of the neuroprotective properties of fenamate NSAIDs, against experimental model of ischemic stroke
… the hypothesis that fenamate NSAIDs have neuroprotective properties against ischemic stroke and to explore the underlying mechanisms for any efficacy.</p> <p>Fenamates are non-selective inhibitors of cyclooxygenases. In addition, fenamates are antagonists of non-selective cation channels, …
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Effect of Maternal Hypoxia on Fetal Development: Programming of HIE Phenotype in Neonatal Rat Brain
… pathway as part of the downstream of the neuroprotective mechanism of the GR against neonate HIE brain injury will be evaluated. To address these issues two rats model were established: perinatal hypoxia exposure model in time-dated pregnant rats and hypoxic-ischemic encephalopathy in …
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Neuroprotective and immunomodulatory properties of the new PPARγ agonist MDG548: an in vitro and in vivo study in PD models
… studies have shown that PPARγ agonists are neuroprotective in experimental PD models in rodents and primates. however safety concerns have been raised about PPARγ agonists thiazolidinediones (TZD) currently available, prompting for the development of non-TZD compounds. Aim of this study was …
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