Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 664 for “"naïve"”.
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Optimization of naïve dynamic binary instrumentation Tools/
The proliferation of dynamic program analysis tools has done much to ease the burden of developing complex software. However, creating such tools remains a challenge. Dynamic binary instrumentation frameworks such as DyanamoRIO and Pin provide support for such tools by taking responsibility for …
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Cellular immunity of naïve and BCG vaccinated neonates
Despite more than 95% vaccination coverage with Mycobacterium bovis Bacille Calmette-Guérin (BCG), tuberculosis (TB) remains epidemic in South Africa. The dichotomy that successful pregnancy is usually associated with a type 2 (Th2) cytokine profile in the newborn child, whereas immunity to …
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Instructing naïve pluripotency ; JAK/STAT3 and Nanog in reprogramming
Reprogramming of somatic cells to pluripotency is a topic of extensive research driven by the potential of induced pluripotent cells in in vitro disease modelling, drug screening and regenerative medicine. The pluripotency associated transcription factor Nanog has been subject to a lot of …
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Cytokine signaling control of naïve CD8⁺ T-cell homeostasis
Mounting effective adaptive immune responses requires a large naive T-cell population with a wide diversity of target specificity. Naive CD8⁺ T-cells depend on T-Cell Receptor (TCR) and ye cytokine signals for their homeostatic survival and proliferation, but differences in sensitivity to these …
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The NuRD complex regulates chromatin dynamics driving exit from naïve pluripotency
The Nucleosome Remodelling and Deacetylase (NuRD) complex is essential for exit from naive pluripotency both in mammalian embryonic stem cell (ESC) culture and in vivo. However, the specific mechanisms of chromatin modulation by NuRD in this process have not been fully characterised. This study …
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Disinhibition in South African treatment-naïve adolescents with alcohol use disorders
… are likely to differ from younger, treatment-naïve individuals, such as the sample here studied. Further, few studies have examined several domains of disinhibition simultaneously, and so little is known about relationships between the various correlates of disinhibition. This study aimed to …
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Mechanistic Dissection of Tcf7l1-Dependent Enhancer Decommissioning During Exit from Naïve Pluripotency
The transition out of naïve pluripotency requires the simultaneous dissolution of the naïve gene regulatory network as well as a redirection of transcriptional response to Wnt/β-catenin signaling. Here, we show that Tcf7l1 functions as a linchpin factor that connects the two outcomes via effects at …
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Dendritic Cells Suppress Pathogen-Induced Inflammasome Activation to Prime Naïve T Cells
Activation of inflammasome leads to pyroptotic cell death thereby eliminating the replicative niche of virulent pathogens, a process integral to innate immunity. While inflammasome-associated cytokines such as IL-1β and IL-18 have an established role in T cell function, whether inflammasome …
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Discrimination of Tone Contrasts in Mandarin Disyllables by Naïve American English Listeners
<p>The present study examined the perception of Mandarin disyllabic tones by inexperienced American English speakers. Participants heard two naturally-produced Mandarin disyllables, and indicated if the two were the same or different. A small native Mandarin-speaking control group participated as …
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Cellular and Molecular Aspects Of Naïve T cell Priming for Adoptive Immunotherapy
… cells. In this thesis we examine aspects of naïve T cell culture with the aim of improving polyclonal and antigen specific expansions for use in adoptive immunotherapy. We show that while traditional monocyte-derived dendritic cells are variable in phenotype, ex vivo monocytes stimulated with …
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The role of SOCS3 in nuclear reprogramming and naïve pluripotency network integration
… and epigenetically sequential stages – naïve (embryonic stem cells, or ESCs) and primed (post-implantation epiblast stem cells, or EpiSCc). Revolutionary technologies of nuclear reprogramming are now able to artificially revert developmental vector and direct differentiated cells towards …
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Intrinsic heterogeneity in the survival and proliferation capacities of naïve CD8⁺ T cells
This thesis describes the identification and characterization of a novel 'layer' of intrinsic non-genetic functional heterogeneity within the seemingly homogeneous naive CD8⁺ T cell population in their survival and proliferation capacities. This heterogeneity is predictably marked by the surface …
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Defining Genes and Circuits Affecting Naïve and Experience-Dependent Alcohol Preference in Drosophila melanogaster
… preference compared to wild type's initial naïve aversion. In contrast, flies specifically lacking Rsu1 in the mushroom bodies show normal initial aversion to alcohol, but then fail to acquire ethanol preference like normal flies do. Our data show that not only is Rsu1 required for normal …
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A Sentiment Analysis of "Filipinx" on Twitter Using a Multinomial Naïve Bayes Classification Model
… Twitter containing “Filipinx”, and to train a Naïve Bayes model to classify tweets into three sentiments: positive, neutral, and negative. My methodology takes inspiration from that of four related studies that similarly conducted sentiment analysis on English/Filipino tweets involving various …
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Studying the principles of cell identity transitions using naïve pluripotency induction as a model
… on reprogramming from epiblast stem cells to naïve pluripotency. By independent modulation of genetic and signalling parameters followed by isolation of successfully transitioning cells, I showed that naïve pluripotency can be established via distinct routes. These differ in their …
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Comparing Naïve Bayes Classifiers with Support Vector Machines for Predicting Protein Subcellular Location Using Text Features
… the SVM classifier in EpiLoc and HomoLoc, by a naïve Bayes classifier and by a novel classifier which we call the Mean Weight Text classifier. The Mean Weight Text classifier and the naïve Bayes classifier are simple to implement and execute efficiently. In addition, naïve Bayes classifiers have …
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Investigation of the synovial tissue-homing mechanisms of circulating mononuclear phagocytes in treatment-naïve psoriatic arthritis.
… migration to joint tissue in active treatment-naïve PsA. I profiled each circulating MPs subset from health and active treatment naïve PsA patients by bulk RNA sequencing. This identified the differences in tissue homing and adhesion markers between the different MPs subsets. I used this to …
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A study into the biology of mESCs exiting naïve pluripotency and technology development for subcellular proteomics
… specifically, is represented in vitro by naïve ESCs, which resemble the pre-implantation mouse embryo, and primed Epiblast Stem Cells (EpiSCs), which are most similar to the post-implantation mouse embryo. In recent years, the exit of mESCs from naive pluripotency has been partially …
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Preventing Thymus Involution In K5.Cyclin D1 Transgenic Mice Sustains The Naïve T Cell Compartment With Age
… involution during the aging process reduces naïve T cell output, leading to defective immune responsiveness to newly encountered antigens. We have found that early thymus involution precipitates the age-associated shift favoring memory T cell dominancy in young control mice. Furthermore, we …
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A diffusion tensor imaging and neurocognitive study of ART-naïve and ART-treated children in Cape Town
… treatment (ART) for a minimum of 6 months or ART naïve. Neuroimaging was completed on 105 children in the cohort study. We compared 75 children vertically infected with HIV aged 6 to 16 years, including both children on antiretroviral therapy (ART) and ART-naïve, with 30 matched controls using …
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