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Showing 1 to 20 of 31 for “"myasthenia gravis"”.
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Lungenfunktionsuntersuchungen bei Patienten mit Myasthenia gravis pseudoparalytica
Myasthenia gravis ist eine Autoimmunerkrankung, bei der die repetetive Erregung und andauernde Belastung der motorischen Endplatte zu einer rasch abnehmenden Kraftentwicklung führt. Kommt es zur Involvierung der Atemmuskulatur, steigt das Risiko für eine myasthene Krise mit lebensbedrohlicher …
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Apoptosemessungen bei Thymompatienten mit und ohne Myasthenia Gravis
Thmyome komen sehr selten mit und ohne Myasthenia Gravis vor und sind ein gutes Beispiel für Autoimmunerkrankungen
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Neuropsychiatric symptoms in thymoma-associated and non-thymoma myasthenia gravis
Myasthenia gravis (MG) is an acetylcholine receptor antibody- mediated disease targeting the neuromuscular junction resulting in fatigable muscle weakness. A number of reports have suggested a high prevalence of psychiatric symptoms amongst MG patients. Approximately 10% of MG subjects are found to …
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Exploring the experiences of South African youth living with myasthenia gravis
… experiences of South African youth living with Myasthenia Gravis (MG). Myasthenia gravis is a rare autoimmune disease marked by skeletal muscle weakness caused by the breakdown of communication between nerves and muscles at the neuromuscular junction. The aim was to understand how MG affects …
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Understanding the function of ICOS/ICOSL costimulation in experimental autoimmune myasthenia gravis
… costimulation in experimental autoimmune myasthenia gravis (EAMG), a model of human MG. Following acetylcholine receptor (AChR) immunization, ICOS gene-deficient mice were resistant to the development of EAMG due to faulty germinal center formation, decreased levels of anti-AChR IgG of all …
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Health Information Needs of Patients Living with Myasthenia Gravis: A Narrative Inquiry
Myasthenia gravis (MG) is a rare autoimmune disease that affects the neuromuscular junction of voluntary muscles, resulting in muscular dystrophy. The disease is termed the snowflake disease due to the variability of symptoms, disease progression, and effective treatments for each person. As the …
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The Level of Antiacetylcholine Receptor Antibodies in the Patients with Myasthenia Gravis
… the neuromuscular transmission. These make the myasthenia gravis (MG) which may cause ptosis, diplopia, dysarthria, dysphagia, generalized weakness, or even respiratory failure. In the previous studies level of antiacetylcholine receptor antibody did not correlate to the severity of patients …
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Morphologie and Pathologie des menschlichen Thymus im Alter und bei Myasthenia gravis: eine morphometrische Studie
… des Thymus bei der Autoimmunkrankheit Myasthenia gravis untersucht.
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Cellular requirements for antibody production in a novel LPS-enhanced model of autoimmune myasthenia gravis
… responses to acetylcholine receptor (AChR) in myasthenia gravis (MG) was evaluated in wild type (WT), CD4-/-, and CD8-/- C57BL/6 mice. Historically, MG\r\nhas been induced in mice by immunization with AChR emulsified in complete Freund’s\r\nadjuvant (CFA). WT mice immunized with AChR in LPS …
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Myasthenia Gravis mimics: An audit of cases identified at Groote Schuur Hospital over 20 years
Background: Myasthenia gravis (MG) is characterised by fatigable muscle weakness. The diagnosis is made clinically and supported by ancillary tests such as electrophysiological studies, autoantibodies and pharmacological responses. Autoimmune MG will respond to immune therapy. Although there are …
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Investigating the functionality of candidate susceptibility genes in ophthalmoplegic myasthenia gravis using patient-derived material
Ophthalmoplegic myasthenia gravis (OP-MG) is a subphenotype of an autoimmune disease, myasthenia gravis (MG). This subphenotype described by our group is characterised by extraocular muscle (EOM) weakness which does not respond to standard immunosuppressive therapy whilst the non-ocular muscles do …
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Treatment-resistant ophthalmoplegia in myasthenia gravis: Clinical, molecular and functional studies of patient-derived orbital tissues
Introduction: Myasthenia gravis (MG) is an immune-mediated disorder affecting the neuromuscular junction. Weakness of the extraocular muscles (EOMs) occurs frequently in MG and typically responds to immune therapies similarly to the non-ocular muscles. Susceptible individuals with the …
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The Development and Use of an Intraoral Force Transducer in the Diagnosis and Treatment of Myasthenia Gravis
Myasthenia gravis is a neuromuscular disease characterized by variable weakness following voluntary muscle exertion. Because responses to the disease vary considerably between muscle groups, as well as between stages of the disease, diagnosis sometimes becomes a difficult and subjective evaluation. …
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Identifying the molecular basis for treatment resistance in a subset of myasthenia gravis patients of African ancestory
Myasthenia gravis (MG) is an autoimmune disease in which pathogenic antibodies block, target or destroy the acetylcholine receptors of the muscle endplate resulting in failure of neuromuscular transmission and fatigable weakness. We have previously shown that a subpopulation of South African MG …
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A modular and adjustable ptosis crutch as a non-surgical solution to elevating the upper eyelid of myasthenia gravis patients
Myasthenia Gravis (MG) is a treatable autoimmune disorder that affects the neuromuscular junction. MG is characterised by fatigable muscle weakness of voluntary skeletal muscles with the most commonly affected muscles being the eye and facial muscles. Patients of African genetic ancestry, …
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Molecular analysis of decay accelerating factor as a potential susceptibility factor to developing treatment resistant extraocular muscle involvement in Myasthenia Gravis
Myasthenia gravis (MG) is an autoimmune disorder in which auto-antibodies directed at the acetylcholine receptors (AChR) of the neuromuscular junction (NMJ) block, alter or destroy their targets. The anti-AChR antibodies cause activation of the classical complement pathway leading to inflammatory …
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Treatment-resistant ophthalmoplegia in Myasthenia gravis: extraocular muscle pathology, the role of TGFβ1 and the derivation of induced pluripotency towards 'disease-in-a-dish' modeling
Myasthenia gravis (MG) is an autoimmune disease in which pathogenic antibodies target specific neuromuscular junction proteins, most frequently acetylcholine receptors (AChR). Among those without detectable AChR-antibodies, a subgroup of patients has antibodies directed against muscle-specific …
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ΜΕΛΕΤΗ ΤΗΣ ΒΑΡΕΙΑΣ ΜΥΑΣΘΕΝΕΙΑΣ ΚΑΙ ΤΟΥ ΥΠΟΔΟΧΕΑ ΤΗΣ ΑΚΕΤΥΛΟΧΟΛΙΝΗΣ ΜΕ ΤΗΝ ΒΟΗΘΕΙΑ ΜΟΝΟΚΛΩΝΙΚΩΝ ΑΝΤΙΣΩΜΑΤΩΝ
MYASTHENIA GRAVIS (MG) IS A NEUROMUSCULAR DISORDER MANIFESTED BY WEAKNESS AND FATIGABILITY OF VOLUNTARY MUSCLES DUE MAINLY TO AUTOANTIBODY-MEDIATED LOSS OF ACETYLCHOLINE RECEPTOR (ACHR). ACHR IS A MEMBRANE GLYCOPROTEIN (M.W.-290,000) COMPOSED OF FIVE SUBUNITS IN THE MOLECULAR RATIO OF A2BΓΔ. …
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