Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 215 for “"mouse brain"”.
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Primitive Neural Stem Cells in the Mouse Brain
… lining the lateral ventricles of the adult mouse brain. At the top of the hierarchy are primitive (p)NSCs that arise in advance of definitive (d)NSCs embryonically. After the discovery that pNSCs persist in the adult mouse brain, I sought out to characterize pNSCs and determine whether they …
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Gray matter covariance networks in the mouse brain
… of correlation between gray matter volumes of brain regions - as measured across subjects in a group of individuals - has been consistently described in several human studies, an approach termed structural covariance MRI (scMRI). Complementary to prevalent brain connectivity modalities like …
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Genetic and Biochemical Analysis of Mouse Brain Gangliosides
Made available in DSpace on 2014-12-14T15:38:02Z (GMT). No. of bitstreams: 1 7709181.pdf: 4094753 bytes, checksum: 1df22f7b85743239dccb45e91e590e98 (MD5) Previous issue date: 1976
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Isolation and characterisation of synaptic vesicles from mouse brain
Alle Eukariotischen Zellen führen einen konstanten Transport von Membranekomponenten duch Vesikel zwischen den Subzellulären Kompartimenten durch. Ein klassichen Beispiel für diesen Transport sind synaptische Vesikel, welche eine wichtige Rolle in der Ausschüttung von Neurotransmitter spielen. …
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Synaptome mapping of glutamatergic synapses across the mouse brain
… to map individual synapses at the whole-brain level, in a quantitative and unbiased manner. This method was used to generate PSD95 and SAP102 synaptome maps – i.e. comprehensive maps of PSD95 and SAP102 positive synapses – in the mouse brain and to achieve three aims: i) characterise …
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Epigenetic regulation of neuroinflammation in the aged mouse brain
… a critical role in regulating the progression of brain aging. However, an important question remains of whether inflammatory pathways become hyperactivated with age, or whether deficient immune responses, which fail to cope with age-related deterioration, may contribute to disease. Microglia, the …
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Localization of Goα in the Developing and Adult Mouse Brain
… most abundant heterotrimeric G protein in the brain but the roles and effectors for the Go have not been clearly defined. As previously reported, the expression of Go protein is found in various brain regions, including cerebrum, hippocampus, thalamus, and cerebellum. Although Go is already …
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Regulation of Brain-Derived Neurotrophic Factor in the Adult Mouse Brain
In the adult central nervous system (CNS) brain-derived neurotrophic factor (BDNF) has been implicated in neuroprotection and synaptic plasticity among other functions. However, relatively little is known of its regulation. In this thesis, we attempted to learn more about BDNF regulation by means …
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Dissecting the Physiological Roles of ULK1/2 in the Mouse Brain
… to investigate the roles of ULK1/2 in the brain. Mice lacking Ulk1 and Ulk2 in their central nervous systems (CNS) showed defects in axonal pathfinding and defasciculation affecting the corpus callosum (CC), anterior commissure (AC), corticothalamic axons (CTAs) and thalamocortical axons …
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Stereological Analysis of Oligodendrocyte Progenitor Cells In the Adult Mouse Brain
The main goal of this study was to further explore the hypothesis that experience-dependent neural network activity and neurotransmission can modulate adult OPC proliferation and differentiation. More specifically, we used stereology to establish whether extensive reference memory training and …
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Different Genetic Ways for Conditional Gene Regulation in the Mouse Brain
… the function of the Tetregulated genes in the brain when inserted into the chromosome and when applied as extra-chromosomal elements with recombinant Adeno-Associated Virus (rAAV). First, the pool of tTA expressing mouse lines was increased by generating eight functional itTA-expressing …
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Neuroinflammation in Alzheimer’s Disease Mouse Brain Following Repetitive Mild Traumatic Brain Injury
<p>Traumatic brain injuries (TBIs) are a common form of head injury, with mild TBIs (mTBIs) making up 75-90% of the TBI severity scale. It’s been suggested that repetitive mild TBIs (rmTBIs) may enhance effects of Alzheimer’s Disease (AD). With dementia linking TBI and AD together, we investigated …
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Increasing the optical transparency of a living mouse brain (and other nanotechnologies)
… the optical transparency of non-living brain tissue have come into widespread use because of their utility in enabling better anatomical brain imaging. In the first part of this thesis, we explore whether this is also possible for living brain tissue. We report a general principle for …
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EFFECT OF ALCOHOL ON THE REGULATION OF ADENYLATE CYCLASE ACTIVITY IN MOUSE BRAIN.
… THE REGULATION OF ADENYLATE CYCLASE ACTIVITY IN MOUSE BRAIN.
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Investigation of Phospholipids in Ethanol Affected Prenatal Mouse Brain Using DESI-MS Imaging
… distribution in various regions of the brain using DESI-MS imaging. FASD mouse models were used in this study in which alcohol was administered to the pregnant mice during first trimester and 30 day old offsprings were chosen for the analysis. Principal component analysis was performed …
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Detection of Stroke, Blood Vessel Landmarks, and Leptomeningeal Anastomoses in Mouse Brain Imaging
Collateral connections in the brain, also known as Leptomeningeal Anastomoses, are connections between blood vessels originating from different arteries. Despite limited knowledge, they are suggested as an important contributor to cerebral stroke recovery that allows additional blood flow through …
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