Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 69 for “"molecular profiling"”.
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MOLECULAR PROFILING OF UROTHELIAL CARCINOMA
The general aim of this thesis was to molecularly characterize urothelial carcinoma (UC) at the transcriptional level using gene expression microarrays to improve the classification and pathogenetic understanding of this disease. In the first two studies (Articles I and II), gene expression …
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Proteogenomics for Personalised Molecular Profiling
… a key platform for generating unique functional molecular data. Furthermore, the integrative analysis of genomic and proteomic data, termed proteogenomics, has emerged as a new field revealing insights into gene expression regulation, cell signalling, and disease processes. However, the lack of …
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Detecting and molecular profiling cancer cells in patients
… technologies to improve our understanding of the molecular signatures of cancer in clinical samples. In the first section, we describe a diagnostic magnetic resonance (DMR) device that was developed for point-of-care analyses of human tumors. We optimized a magnetic nanoparticle assay to improve …
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Establishing the feasibility of using ctDNA for molecular profiling in DLBCL
DLBCL is a molecularly heterogeneous disease. Many clinical trials have failed to demonstrate improvements to survival by altering first line therapy. This may be due to failure to stratify patients in a way that reflects this molecular heterogeneity. Over the last 5 years, three large DLBCL …
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Molecular Profiling and Mechanisms of Cerebrovascular Function in Health and Neurodegeneration
… single-cell technologies. Here we characterize molecular profiles of cell types that comprise the human cerebrovasculature using both ex vivo fresh tissue and post mortem in silico sorting of human brain tissue samples. Using single-nucleus RNAsequencing (snRNA-seq), we profile cerebrovascular …
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Identifying Pathogenic Variants In Hereditary Cancer Syndrome Genes Via Tumor Molecular Profiling
<p>Tumor molecular profiling is often performed in order to direct cancer treatment options. However, because many of the genes analyzed on tumor molecular profiling overlap with genes known to be associated in the germline with hereditary cancer predisposition syndromes, tumor molecular profiling …
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Molecular profiling in early stage IB1 squamous cell carcinomas of the uterine cervix.
… purpose of this research was to clarify the molecular mechanisms of progressive IB1 cervical disease in order to stratify risk to better match multi-modality therapy to minimize morbidity, mortality, and costs. The goal is to improve characterization of the tumor to individualize therapy. …
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Molecular Profiling of Antibiotic Resistant Bacteria and Genes in Raw and Drinking Water
Antibiotic resistant bacteria and antibiotic resistant determinants are regarded as emerging public health threats in drinking water systems. Heterotrophic Plate Count bacteria in distribution pipes are used as direct parameters to assess the conditions of water in distribution systems. Moreover, …
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High-Throughput Single-Cell Functional and Molecular Profiling of Immune Cells in Cancer Immunotherapy
… of potencies to understand the phenotypic, molecular, and functional contribution of infusion products at single-cell level. In the first part of this dissertation, we implemented Timelapse Imaging Microscopy in Nanowell Grids (TIMING) to demonstrate that while CD4+CAR+ (CAR4) cells killed …
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Translational Studies of Acute and Chronic Traumatic Brain Injury: Molecular Profiling of Tissue and Biofluids
… were performed to gain insight into potential molecular mechanism of injury. Translational studies were initially performed in rats using a well-established model of TBI, fluid percussion injury (FPI). Rats were sacrificed, and tissue harvested at various post-injury intervals (4 TBI, 4 Sham …
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Molecular Profiling: Gene Expression Reveals Discrete Phases of Lens Induction and Development in Xenopus Laevis
"From these genes, two were examined to further characterize their roles in development and transdifferentiation. The matrix metalloproteinase Xmmp-9 was found to function during migratory and morphogenetic processes during development, and it was found to be upregulated during wound healing. Psf2 …
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Central and peripheral molecular profiling of sex differences in schizophrenia, major depressive disorder, and controls
… males and females. This thesis sought to examine molecular sex differences in control subjects and in schizophrenia and MDD patients by profiling serum and prefrontal cortex (PFC) brain tissue. Multiplex immunoassay and microarray technologies were used to measure concentrations of proteins and …
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Metabolic, biochemical and molecular profiling of Catharanthus roseus flower cultivars and transformed hairy roots for monoterpenoid indole alkaloid accumulation /
… of Catharantlws rosellS has prompted metabolic profiling studies to determine the variability of MIA accumulation of existing flowering cultivars, with particular focus on the vindoline component ofthe pathway. Metabolic profiling studies that used high performance liquid chromatography of MIAs …
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Occurrence and Control of Microbial Contaminants of Emerging Concern through the Urban Water Cycle: Molecular Profiling of Opportunistic Pathogens and Antibiotic Resistance
… characterization were applied together towards profiling L. pneumophila in clinical and water samples collected from Flint, Michigan, where an economically-motivated switch to an alternative water source created conditions favorable for growth of this organism and likely triggered one of the …
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Bayesian Spatial Analysis of High Throughput Sequencing Data
… of RNA Sequencing (RNA-Seq) coupled with other molecular technologies such as methylated RNA immunoprecipitation (MeRIP) and spatial barcoding has delivered more specialized platform to investigate certain cellular process and spatial molecular profiling. However, the development of associated …
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Multivariate Models and Algorithms for Systems Biology
… often interpreted as pathway components, from molecular profiling data with replicated measurements. We translate our goal into learning an optimal correlation structure from replicated complete and incomplete measurements. In the second part, we focus on thereconstruction of signal …
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Teak: A Novel Computational And Gui Software Pipeline For Reconstructing Biological Networks, Detecting Activated Biological Subnetworks, And Querying Biological Networks.
… modules query against the KEGG pathways using molecular profiling data and query graphs, respectively. In particular, the second module, also called TEAK, is a network partitioning module that partitions the KEGG pathways into both linear and nonlinear subpathways. In conjunction with molecular …
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Mapping Molecular Changes in Human Neuropsychiatric Disorders to Zebrafish Behavioral Profiles
… has remained elusive. Recent advances in molecular profiling have allowed researchers to probe genetic and transcriptomic differences in post-mortem samples from individuals with healthy and diseased brains, which has provided some hints into the underlying biological dysregulation in …
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SILVER NANOPARTICLES ARE EFFECTIVE FOR THE TREATMENT OF CLAUDIN LOW BREAST CANCER AND OTHER MESENCHYMAL CANCERS WITH HIGH ZEB1 EXPRESSION
… women will die from BC in 2017. With advances in molecular profiling, breast cancer has been divided into 5 molecular subtypes (luminal A, luminal B, HER-2 overexpressing, basal-like, and claudin-low) that have distinct genetic aberrations, morphological features, prognoses, and therapeutic …
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