Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"molecular diagnostics"”.
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Next-generation molecular diagnostics: Role in outbreaks, drug management and routine Molecular diagnostics.
Contains fulltext : 289614.pdf (Publisher’s version ) (Open Access)
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Novel genomic technologies and molecular diagnostics in Colorectal Cancer
Cancer is a disease of the genome that is characterized by substantial variability in the clinical course and response to therapies. Colorectal cancer (CRC) is a heterogeneous cancer and represents an ideal model to investigate and elucidate the genetic alterations involved in tumor onset and …
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Haemobartonella Felis (Mycoplasma Haemofelis) Molecular Diagnostics and Genomic Studies
Little was known about the genome size or structure of the haemotrophic mycoplasmas and studies of pathogenicity, adhesion, and protein production are hampered by the inability to culture H. felis and use more common genetic tools. A renewable source of H. felis DNA in the form of a large insert …
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Encoded hydrogel microparticles for high-throughput molecular diagnostics and personalized medicine
… settings. Advancements in genetic analysis, molecular diagnostics, and patient-tailored medicine require robust detection technologies that can obtain high-density information from a range of physiological samples in a rapid and cost-effective manner. Compared to conventional microarrays and …
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Evaluation and Optimization of the Translational Potential of Array-Based Molecular Diagnostics
… is evident. However, the majority of array-based diagnostics have yet to make their way into the clinical laboratory. Current approaches tend to focus on development of multi-gene classifiers of disease subtypes, but very few studies evaluate the translational potential of these assays. Likewise, …
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Molecular diagnostics, genetic diversity and generating infectious clones for cassava brown streak viruses
Cassava brown streak disease (CBSD) threatens cassava production in eastern and southern African countries. Diagnostic protocols currently available for the causal agents of CBSD, Cassava brown streak virus (CBSV) and Cassava brown streak Uganda virus (CBSUV), were unreliable but were urgently …
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Bridging the "Valley of Death" in stratified medicine : commercializing molecular diagnostics in oncology
Historically, the development of molecular companion diagnostics in oncology has underwhelmed the expectation of the medical field since the successful mapping of the human genome a decade ago. There have been several highly successful developments (Her2-neu, Genomic Health, etc.), but not the …
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Hierarchical selective electrokinetic concentration : the universal next-generation biomolecule enrichment technique for molecular diagnostics
… biological media may greatly advance clinical diagnostics and biotechnology development. Because of the slow mass transport and weak binding kinetics at ultralow concentration of target biomolecules, enrichment of target biomolecules plays an essential role in the detection of …
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Improving Medicare & Medicaid Reimbursement Framework for Molecular Diagnostics Tests Using Gene Sequencing: A Case Study in Health Economics
… In the recent past, research has shown that molecular diagnostic tests have revealed that about 20% of the tumors carry the HER-2 mutation on cell surface, which can be treated with the drug Herceptin, or trastuzumab, improving cancer free survival rates from 71.9% to 84.2% in five years. …
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Using Molecular Diagnostics Based On Internal Transcribed Spacer 2 Sequence To Study Geographical Distribution of Holarctic Malaria Mosquitoes
Diseases like malaria claim the lives of millions of people every year. This deadly disease can result in considerable morbidity, which presently affects countries in Africa, Eurasia, and South America. Anopheline mosquitoes transmit this disease. Studies look at the identification first of the …
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Multimodal Optical Interfaces Enabled by Multiresonant Plasmonics for Bio-Nanophotonics
… have enabled transformative advances in molecular diagnostics, therapeutic monitoring, and cellular manipulation. However, challenges remain in achieving continuous real-time sensing, intracellular probing, and controlled actuation within an integrated, multifunctional platform. …
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New Clinical Guidelines for Cervical Cancer Screening and the Benefits of Implementing a Primary High-risk Human Papillomavirus Test in a High Volume Reference Laboratory
… based Papanicolaou smear (Pap smear) and molecular based high-risk Human Papillomavirus (hrHPV) testing were the best methods for detecting early signs of cervical cancer. However, with the future of clinical tests shifting more towards the utilization of molecular diagnostics, there has …
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Diagnostika leishmanióz u lidí a psů
… been a considerable progress in serological and molecular diagnostics. This thesis focuses on description and comparison of the traditional and the new diagnostic methods. Attention is paid primarily to the new methods, therefore serological and molecular. These methods are compared by their …
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Development of a Multi-Component Biosensor for Recombinase Polymerase Amplification-CRISPR/Cas12a-Based Detection of Fusarium oxysporum f. sp. cubense tropical race 4
… biosensing platform that integrates molecular diagnostics and electrochemical detection for sensitive and portable detection of Foc TR4 DNA. The system combines microneedle-based DNA extraction, Recombinase Polymerase Amplification (RPA), Clustered Regularly Interspaced Short …
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An integrative bioinformatics approach to characterize molecular landscapes and clinical outcomes in acute leukemias
… population-based disease patterns, RNA-seq-based molecular classification, and developmental interpretation. First, nationwide German cancer registry data were used to characterize acute leukemias. The analyses revealed age-dependent differences in incidence, treatment, and survival. Rare …
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High Throughput, Multiplex Quantification via Nucleic Acid Chemical Reaction Network Perturbation
… quantification has the potential to transform molecular diagnostics. For example, proteomic analysis could be a powerful medical tool to assess a patient's current state of health. However, most of the widely used molecular quantification techniques have yet to achieve both high throughput and …
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Advancing detection, genomics, and secretome analysis of oomycete pathogens Phytophthora capsici and Phytopythium vexans to explore mechanisms of pathogenesis and biocontrol solutions
… as significant threats. Understanding the molecular mechanisms underlying their pathogenicity is critical for developing informed, site-specific disease management strategies. This thesis integrates comparative genomics, effector biology, and molecular diagnostics to enhance our …
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The application of loop mediated isothermal amplification for the detection of the sexually transmitted pathogens Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, and Trichomonas vaginalis, at the point of care.
… attempt at commercialising a fully integrated molecular diagnostics system based on LAMP.
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Identification and Characterization of Novel Astroviruses
… diarrhea. Despite the availability of improved molecular diagnostics to detect the known viral agents, the etiology of a large proportion of diarrheal cases is unknown. In fact, it is estimated that no causative agent can be identified in up to 40% of sporadic cases or in gastroenteritis …
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