Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"microdevices"”.
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Study of disposable microdevices for DNA electrophoresis
A study was undertaken to determine if a microfluidic chip, made of economical plastic materials, is feasible. The chip was designed to perform gel electrophoresis, specifically of DNA fragments for either sequencing or identification purposes. With a disposable version of such a chip, constraints …
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Single molecule analysis of DNA electrophoresis in microdevices
Given that current electrophoresis technology is inadequate for mapping large O[100 kilobasepair] DNA, several promising lab-on-chip designs for DNA mapping have been recently proposed that require either 1) a DNA molecule negotiating an obstacle course in a microchannel or 2) stretching a DNA …
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Particle Manipulation Using Electric Field Gradients in Microdevices
Electrokinetics is a family of effects that induces motion of a liquid or a particle within a liquid in response to an external electric field. Using the intrinsic electrical properties of bacteria and of breast cancer cells, electrokinetics can be used to manipulate these particles for two …
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Microchip Liquid Chromatography and Capillary Electrophoresis Separations in Multilayer Microdevices
… systems and multilayer capillary electrophoresis microdevices with crossover channels were fabricated using various substrates such as poly(dimethylsiloxane) (PDMS), glass, and poly(methyl methacrylate) (PMMA). I have demonstrated pressure-driven pumping of liquids in microfabricated channels …
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A study of loading parameters that affect DNA electrophoresis in microdevices
… upgraded electrophoretic protocols and future microdevices.
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Microdevices for Investigating Pulsed Electric Fields-Mediated Therapies at Cellular and Tissue Level
Recent attempts to investigate living systems from a biophysical point of view has opened new windows for development of new diagnostic methods and therapies. Pulsed electric fields (PEFs) are a new class of therapies that take advantage of biophysical properties and have proven to be effective in …
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Microdevices for Isolating Single Axons for the Study of Axonal Transport in Dopaminergic Neurons
<p>Axonal degeneration plays an important role in the etiology of major central nervous system: CNS) neurodegenerative disorders such as Parkinson's disease: PD) but investigations into the mechanisms underlying this important process has been limited. The goal of this dissertation was to design …
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Towards Early State Disease Detection in Microdevices: Fabrication and Testing of Micro Total Analysis Systems for Bioanalytical Applications
… illustrate bioanalytical applications of these microdevices. Initial on-chip infrared spectroscopy results for qualitative analyte identification were achieved in microfluidic CaF2 channels. I have also shown the evaluation of poly(methylmethacrylate) (PMMA) and thermoset polyester (TPE) …
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The Piezoresistive Effect In Microflexures
… to optimized sensors, feedback control of microdevices, nanopositioning, and self-sensing microdevices.
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3D integration of micro- and nanostructures into bio-analytical devices
… nanomolding process and solvent assisted bonding microdevices with no side, one side, three sides and four sides patterned were fabricated. To characterize 3D flow patterns induced by the surface structures on microdevices, confocal microscopy was used as dyed water and undyed water injected from …
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Microfluidic differentiation of subpopulations of cells based on their bioelectrical signature
… fields. The coupling between the geometry of the microdevices and applied fields makes the prediction of associated forces inside the microdevice challenging and increasingly difficult when the applied field is time-dependent. Understanding the interaction of external forces and particles and …
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Polymer Microchips for Capillary Electrophoresis and Electric Field Gradient Focusing of Biomolecules
… I showed that poly(methyl methacrylate) (PMMA) microdevices could be enclosed in a boiling water bath, which allowed the seal to form more quickly than in conventional approaches, and enabled microchannels to remain hydrated throughout the bonding process. Microchip capillary electrophoresis …
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A potential route to hydrogel multifunctionalization utilizing encapsulation of acrylate-conjugated streptavidin
… range of applications from tissue engineering to microdevices have begun to revolutionize biomedical science. New chemistries, however, must be developed for functionalization of these materials with each different molecule. This paper explores a technique for developing multi-functional, …
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Controlling crystallization via interfacial engineering : patterning, fouling-inhibition, and nutrient recovery
… masks with applications for the fabrication of microdevices.
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Membrane-Based Protein Preconcentration Microfluidic Devices
… also injected and separated in these integrated microdevices. Membrane-based protein preconcentration devices can significantly increase the concentration range of biological samples that can be analyzed by microchip CE.
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NeuroModular - A Modular Backend for Fiber-Based Wireless Bioelectronic Interfaces
… with the functional maturity of solid-state microdevices. Wireless operation of multifunctional fiber-based devices would allow neuromodulation in the central and peripheral nervous systems in awake behaving animals, allowing more naturalistic behaviors compared to wired operation. In this …
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Protein responsive synthetic materials for biomedical applications
… Immunosorbent Assay) or as a sensing element in microdevices formed through standard photolithographic processes"--Abstract, page iv.</p>
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Impedance spectroscopy for cellular and biomolecular analysis
… the rapid development of a novel class of microdevices collectively known as ‘Lab On a Chip’ devices.<br/>Impedance spectroscopy is a non-invasive, label-free, analytical technique that is amenable to miniaturization, electronic integration, automation, and scalability within ‘LOC’ …
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Continuous focusing and separation of microparticles with acoustic and magnetic fields
… address some of the limitations of conventional microdevices, but also provide simple and efficient method for the separation of microparticles and biological cells with different sizes, materials and shapes, and will benefit practical microfluidic platforms concerning micron sized …
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Extending the Flexibility of an RFIC Transceiver Through Modifications to the External Circuit
… is focused on investigating modifications to RF Microdevices' suggested external circuit for the RF29X5 family of low cost, half duplex, FM/AM/ASK/FSK RFIC transceivers originally intended for operation in the 433, 868, or 902-928 MHz industrial, scientific, and measurement (ISM) bands. …
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