Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"methylations"”.
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Direct Analysis of Intact Proteins From Microorganisms Using Top Down Mass Spectrometry
… including acetylations, phosphorylations, methylations, formylations and oxidations.
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Top Down Mass Spectrometry of Archaea and Human Tumor Cells
… including N-terminal and internal acetylations, methylations, disulfide bonds, and protein truncations. Proteins were also characterized with known coding single nucleotide polymorphisms, alternative splice variants, and highly homologous gene family members.
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The methylation of aminopteridines and aminopyrimidines
… by an historical account of the earlier methylations which are relevant to the work undertaken, and is followed by a discussion of the results of the physico-chemical measurements made during the investigations.
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The methylation of aminopteridines and aminopyrimidines
… by an historical account of the earlier methylations which are relevant to the work undertaken, and is followed by a discussion of the results of the physico-chemical measurements made during the investigations.
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Protein factors involved in the biogenesis of the mitochondrial ribosome
… modifications of the mt-rRNAs include base methylations, 2’-O-ribose methylations and pseudouridylation. However, the exact function of these modifications is unknown. Many mitoribosome biogenesis factors still remain to be identified and characterised. This work aims to broaden our …
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Atomistic Investigation of Nucleosomal H3 Histone Tail in Unmodified and Epigenetically Modified States
… modification of the lysine by acetylation or methylations in Segment I versus multiple residue modifications by serine phosphorylation or lysine methylations have marked effects on the tail's flexibility and interaction with the DNA. This study highlights the significance of proline residues …
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Molecular mechanisms of phenotypic plasticity: Explorations of DNA methylation and transcriptional regulation using the honey bee
… genes. Compared to vertebrate genomes, DNA methylations in honey bees are sparse, and all of the identified methylations are intragenic, similar to results shown in other invertebrates. Differences in DNA methylation density and positions suggest possibly different functions of DNA …
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The mechanism of cyanamide/MMS-induced DDI2/3 expression in Saccharomyces cerevisiae
… mutant. In addition, mass spectrometry detected methylations of Fzf1 on K70 and K107 residues after MMS treatment, as well as CY modifications on K122 and K184 residues after CY treatment. Among amino-acid substitutions of the above Lys residues, Fzf1-K70A completely abolished the MMS induction …
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The mRNA Cap and Discontinuous Transcription in Trypansoma brucei
… modified nucleotides are likely to have 2'-O-methylations, and possibly two other unidentified base modifications. The mRNA cap was indistinguishable from the medRNA cap. The cap structure is likely to be similar in the other Kinetoplastidae. This hypermethylated cap structure may have a …
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Identification of a Functional Hotspot on Ubiquitin Required for Stimulation of Methyltransferase Activity on Chromatin
… responsible for the regulation of H3K4 and H3K79 methylations, through the direct stimulation of methyltransferase activity specific to the installation of these marks. Interested in the surface features on ubiquitin required for H2B-Ub stimulation of the human H3K79 methyltransferase, hDot1L, we …
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Selective Chemical Reactions for Nucleic Acid Sequencing and DNA-Encoded Library Synthesis
… human diseases. Amongst the most widely studied methylations is N6-methyladenine, known as 6mA in DNA and m6A in RNA. While traditional methods to sequence these modifications have depended on antibody pulldowns, chemistry-based approaches are often less sequence dependent, can work on either DNA …
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Investigations into the molecular basis of enzyme-catalyzed reactions in natural product biosynthesis
… characterized by a cyclized N-C structure with methylations on the amide group of the peptide backbone. I describe the structural characterization of the tailoring enzyme capable of methylating the peptide backbone, dbOphMA, and attempts to delineate the substrate scope of this enzyme. In the …
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High fat diet causes hepatic lipid accumulation by programming lipid synthesizing genes via gene body methylation
… group. MEDIP-SEQ data showed greater average methylations read peaks for HF/HF along the gene body for GPAM. Methylation specific polymerase chain reaction (MSP) validated these results by showing greater methylation on intron 1, on the 7.2 kilobases (kB) pair region, as well as exon 21, at …
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STRUCTURAL AND FUNCTIONAL STUDIES OF ARCHAEAL BOX C/D GUIDE RNA AND ROLE OF A PUTATIVE HUMAN PSEUDOURIDINE SYNTHASE, PUS10 IN APOPTOSIS
… Archaea, Eukaryotes and Bacteria. Some of these methylations are catalyzed either by a RNA-protein complex or by stand-alone enzymes. The RNA-protein complex (Ribonucleoprotein complex) is comprised of a small RNA known as the guide RNA (Box C/D RNA) and core proteins (L7Ae, Nop5, and …
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Zinc enzyme model complexes with Ligands containing a N2S Donor Set and their methylating reactions
A new tridentate and two new tripodal ligands containing a N2S donor set have <br>been prepared in this work. These and other four selected ligands together with <br>different thiolate co-ligands have been used for the syntheses of 47 new zinc <br>enzyme model complexes. These complexes have been …
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Epigenetics and sex expression in trioecious papaya
… of the Y chromosome (MSY). The HSY specific methylations were clustered in some locations of the chromosome compared to MSY specific methylation. The X chromosome showed higher methylation in female plants than in male and hermaphrodite plants, suggesting that the X chromosome is silenced in …