Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"mechanical compression"”.
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The effect of mechanical compression on chondrocyte gene expression
Thesis (Ph.D.)--Harvard--Massachusetts Institute of Technology Division of Health Sciences and Technology, 1999.
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Mechanical compression of food products during freeze-drying through force produced by springs.
Thesis. 1976. M.S.--Massachusetts Institute of Technology. Dept. of Nutrition and Food Science.
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Localized Mechanical Compression as a Technique for the Modification of Biological Tissue Optical Properties
… clearing methods have been investigated. Mechanical compression is one such alternative tissue optical clearing technique. The mechanisms of action of mechanical compression may be similar to those of chemical clearing, though they have yet to be investigated systematically. This research …
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Measurement of tissue optical properties during mechanical compression using swept source optical coherence tomography
… of incident light. It has been hypothesized that mechanical compression has a great potential to enhance the capabilities of laser therapy by inducing localized water transport, decreasing the refractive index mismatch, and decreasing the scattering coefficient of tissue. To better understand this …
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Investigation of Cellular Responses Activated by Mechanical Compression in Equine Chondrocytes: Device Design, Construction and Testing
… cartilage cells (chondrocytes) is regulated by mechanical forces which act on them. Chondrocytes can respond to these forces through synthesis or degradation of extracellular matrix and changes in gene expression. The overall objective of this study was to investigate the effects of mechanical …
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Cartilage mechanobiology and transcriptional effects of combined mechanical compression and IGF-1 stimulation on bovine cartilage explants
… Previous studies have demonstrated that mechanical compression can regulate the action of IGF-1 on chondrocyte biosynthesis in intact tissue; when applied simultaneously, these stimuli act by distinct cell activation pathways. Our objectives were to elucidate the extent and kinetics of …
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Cartilage mechanobiology : the effects of loading on the fine structure and function of chondroitin sulfate glycosaminoglycans
… them are age, disease, depth of tissue, and mechanical compression. Specifically, mechanical compression has been shown to have a significant effect on the sulfation pattern and chain length and number in cartilage explant studies. The mechanisms that govern these alterations, however, have …
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Mechanics of biocell landfill settlements
… of waste settlement were identified as mechanical compression and biodegradation-induced strain. Mechanical compression was modeled with the help of laboratory simulations. To model the biodegradation-induced settlement, it was assumed that waste degradation obeys the first order …
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Numerical and Experimental Study of Rock Fracture Creep Under Dry Conditions
… or geothermal energy utilization, the hydro-mechanical behavior of rock fractures has a strong effect on the safety and profitability of the project. In field conditions, the hydraulic and mechanical behavior of rock fractures changes with time (the rock fractures creep). Rock fracture creep …
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Carbon nanotube based electromechanical probes
Electromechanical probing applications continuously require smaller pitches, faster manufacturing and lower electrical resistance. Conventional techniques, such as MEMS based cantilever probes have their shortcomings in terms of the lowest pitch that can be achieved, cost and yield. Given their …
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Mechanical Loading for Modifying Tissue Water Content and Optical Properties
… such as water and protein, and the mechanical and optical properties of human skin is important to understand its complex nature. Localized mechanical loading has been proven to alter optical properties of tissue, but the mechanisms by which it is accomplished have not been studied …
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Behavior of passaged chondrocytes in collagen-glycosaminoglycan scaffolds : effects of cross-linking, mechanical loading, and genetic modification of the scaffold
… synthesis throughout a 4-week culture. Static mechanical compression (0-50% strain) applied to cell-seeded EDAC cross-linked scaffolds decreased rates of protein and GAG synthesis while dynamic compression (3% sine amplitude, 0.1 Hz) increased rates of biosynthesis over a 24-hour period. These …
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In vitro models for injurious compression of bovine and human articular cartilage
… This has motivated the use of in vitro models of mechanical cartilage injury in order to identify processes that could lead to cartilage degradation. The overall aims of the work presented here has been to focus on further identification of the effects of in vitro injurious mechanical compression …
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SURVIVING UNDER PRESSURE: TRANSLATIONAL REWIRING IN RESPONSE TO MECHANICAL STIMULI
An outcome of high mechanical stress in the context of hyperproliferation and increased cellular tension is the reduction in cell volume, that holds the potential to impact cellular density. Both cell size and density homeostasis are integral features of healthy tissues, intricately linked to the …
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The development of novel hybrid poly (2-oxazoline)-based bioinks for 3D bioprinting: a comparative study with Pluronic F127
… natural polymers are usually limited by their mechanical strength and have less tunable mechanical characteristics. Instead, synthetic polymers offer adjustable mechanical properties and good printability, and they are often used as sacrificial materials in 3D bioprinting. Hybrid hydrogels …
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Increasing Sequential Compression Device Compliance to Decrease Venous Thromboembolisms and Improve Nursing Documentation
… through the use of pharmacologic agents and/or mechanical compression devices, such as sequential compression devices (SCD). However, less than half of hospitalized patients receive VTE prophylaxis (CDC, 2017). At a large metropolitan hospital, compliance with VTE prophylaxis, specifically with …
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Cartilage response to in vitro models of injury in combination with growth factor and antioxidant treatments
… conditions in vivo, by isolating the effects of mechanical compression, cytokine treatment, and cartilage co-cultured with adjacent tissue, in vitro models can give insight into key biological and mechanical pathways occurring in vivo. This study focuses on changes in cartilage gene and protein …
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Chemomechanics of self-oscillating gels
… tissue exhibit the unique capacity to transduce mechanical stimuli into propagating electrical and chemical signals throughout the body. Few synthetic materials have been engineered to produce communicative chemical signals in response to mechanical input, though such synthetic material analogues …
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Composition and Manufacturing Effects on Electrical Properties of Li/FeS2 Thermal Battery Cathodes
… in a molten salt. The suspension experiences mechanical deformation, or slumping.' This slump changes the mechanical compression of the cell, as well as the tortuosity and electronic and ionic conductivity of the cell as the cathode mesostructure is reordered in response to the external …
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Development of CFRP Class A body panels and structural components for automotive applications
… were completed in two areas of research. Firstly mechanical compression test coupons of unidirectional carbon fibre composite were optimised to produce repeatable and reproducible data to support automotive structural applications. The compressive strength was determined through ASTM D 695 M …
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