Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"lymph node metastasis"”.
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Lymph node metastasis in auricular squamous cell carcinoma
… of the auricle has an unusually high rate of lymph node metastases when compared to similar tumours at other sites. The lymph nodes affected are close to the base of the skull and in the neck. Development of metastasis carries a poor prognosis and most patients will subsequently die of failure …
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Disrupting Tymp-Mediated Pathways to Block Lymph Node Metastasis in Ovarian Cancer
… ovarian cancer, the mechanisms driving lymph node (LN) metastasis are poorly understood, and it remains unclear whether omental metastasis occurs in parallel with LN metastasis. Utilizing comparative transcriptomic and proteomic profiling of primary tumors, LN metastases, and omental …
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Risk of cervical lymph node metastasis in papillary thyroid carcinoma: Correlations with lymphangiogenesis and ultrasound features
Stratification of risk factors for cervical lymph node metastasis (LNM) in thyroid papillary carcinoma is important for providing standards for post-operative adjuvant radio-iodine therapy and for predicting patient prognosis. We investigated pathological factors based on the lymphatic vessel …
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Application of artificial neural networks in breast and colorectal surgery
… the ability of ANNs to predict axillary lymph node metastasis in patients with breast cancer and compared with traditional logistic regression analysis. In addition, the ability of ANNs to generalise across institutions was studied and their ability to predict in individual patient was …
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Dissecting cell-autonomous and microenvironmental factors governing lymphatic metastasis in breast cancer
Metastasis is the primary cause of deaths in cancer patients. Tumour dissemination can occur through the bloodstream or lymphatic system. The presence of tumour cells in the draining lymph node (lymph node involvement) represents the most important prognostic factor for breast cancer patients. …
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Expression of E-cadherin and HGF in Hypopharyngeal Cancer
… the role of the E-cadherin/HGF on invasion and metastasis of hypopharyngeal squamous cell carcinoma(SCC). MATERIALS AND METHOD: We performed immunohistochemical stains on 40 tissues of hypopharyngeal cancer patients who were admitted to Ajou University Hospital & Severance Hospital between Mar. …
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Targeting the bombesin subtype 2 receptor for the diagnosis and treatment of metastatic prostate cancer
… However, undetected extracapsular or regional lymph node metastasis plagues the long-term survival statistics of definitive therapies. In advanced prostate cancer, initial androgen depravation therapy has failed to control cancer progression, and regional lymph node and distant osseous …
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Expression and Clinical Significance of the N-myc downstream regulated gene-1 in Hypopharyngeal Cancer
… downstream regulated gene-1 (Ndrg-1), a potent metastasis suppressor gene, is identified as a gene that is up-regulated by the induction of differentiation in various cancer cell lines. Ndrg-1 has been shown to be involved in tumor progression and metastasis in colon, prostate and breast cancer. …
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Pretreatment Serum CYFRA 21-1 Level Correlates Significantly with Survival of Cervical Cancer Patients: A Multivariate Analysis of 506 Cases
… and Obstetrics (FIGO) stage, large tumor size, lymph node metastasis, and deep stromal invasion. In the stepwise Cox regression analysis, large tumor size > 4cm was an independent prognostic factor for disease-free survival (OR, 3.110; [95% CI, 1.588-6.093], P=0.001) and overall survival (OR, …
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Synthesis and Characterisation of Dual CCR7/CXCR4 Antagonists
Metastasis is a major cause of death in cancer patients but currently there are no drugs available for its treatment. Hence there is an urgent clinical need for identifying and developing anti-metastatic drugs. The activation of CC chemokine receptor 7 (CCR7) and C-X-C chemokine receptor type 4 …
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Early detection of oesophageal cancer based on colour appearance and colour-based data augmentation
… (OC) is detected in its intramucosal stage when lymph node metastasis is unlikely and it still can be treated endoscopically. Hence early detection of oesophageal cancer plays a crucial role. The challenge here is that early stage of caner present subtle changes in comparison with normal skill …
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Role of N-terminal residues of CCL19 and CCL21 in binding and activation of CCR7
… contributing to proliferation, angiogenesis and metastasis. In particular, chemokines CCL19 and CCL21 acting on their associated receptor CCR7 are postulated to be key drivers of lymph node metastasis in a number of malignancies including breast, colon, gastric, & thyroid cancers. It has been …
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Prognostic Value of Bone Marrow Micrometastasis Detected by Nnested RT-PCR for Cytokeratin 19 and Mammaglobin in Breast Cancer
… in the early phase frequently undergo distant metastasis, and survival of patients is greatly dependent on distant metastasis. Occurrence of micrometastasis has been suggested to relate with prognostic features of breast cancer, such as lymph node metastasis and the presence of vascular …
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Impact of no residual versus residual disease after hysterectomy for stage 1 cervical cancer on recurrence
… hysterectomy (29.6%), simple hysterectomy with lymphadenectomy (12.3%) or radical hysterectomy (58.2%). The prevalence of residual disease on hysterectomy specimen was 56.5%, versus no residual disease (43.5%). The overall recurrence rate was 9.5%. Thirty patients received adjuvant radiotherapy, …
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Complications in Laparoscopy-Assisted Gastrectomy: Multivariate Analysis of 300 Consecutive Cases
… operative time, type of surgery, extent of lymph node dissection according to the Japanese Guideline, number of retrieved lymph nodes and lymph node metastasis, additional operative procedure, depth of tumor invasion and stage. Outcome data consisted of mortality, major morbidities, and …
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Cancer Cartography: Mapping Cancer Evolution in Tissue Space
… carcinoma in situ, invasive cancer, and lymph node metastasis reveal clone-specific variations in proliferation, morphology, stroma, hypoxia, and immune microenvironments. In one instance involving ductal carcinoma in situ, polyclonal neoplastic expansions manifest on a macroscopic scale …
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Lymphatic pathophysiology of tumors
Lymph node metastases have a negative impact on cancer survival, but the mechanisms for lymphatic metastasis are not well understood. The universal finding in solid tumors of an absence of functional lymphatic vessels seems paradoxical, as cancer cells do travel through lymphatics in order to …
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Effects of ionizing radiation on normal and tumor-associated lymphatic vessels
Lymphatic vessels play a crucial role in both the pathophysiology of tumors and in the spread cancer cells to lymph nodes. The effects of radiation on these vessels, however, are largely unknown. Here, we seek to describe the effects of ionizing radiation on normal and tumor-associated lymphatic …
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INVASIVE BLADDER CANCER - Aspects on staging and prognosis
… regarding the effects of delay on prognosis, lymph node staging and detection and staging of transitional cell carcinoma (TCC) involving the prostatic urethra and prostate in males. This thesis is based on investigations of the impact of diagnostic and treatment delay on prognosis in invasive …
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