Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 2695 for “"ligands"”.
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Reactions at coordinated ligands: redox-active ligands and coordination of Lewis acids
… three approaches were the use of redox-active ligands, ligand protonation and Lewis acid coordination to ligands. The focus is on ligand design rather than substrate or metal optimization with a primary interest in reactivity with dihydrogen. The main thrust of the work has been the …
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NKG2D Ligands in Cancer
… cell lines that expressed low levels of NKG2D ligands were susceptible to NK cell lysis. Furthermore, we found that only 30% of the cancer cell lines were susceptible to NK cell killing and all of them expressed high level of NKG2D ligands. The dependency on NKG2D pathway in these NK …
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Trans coordinating bidentate ligands
A number of novel bidentate ligands have been designed, which would, because of steric constraints, coordinate exclusively across the trans positions in a square planar complex. Such complexes could show optical activity centred on the metal if the four ligand groups (A,B,C,IJ in the diagram) were …
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Unsymmetrical tridentate phosphine ligands
… the preparation of unsymmetrical triphosphine ligands, which necessarily contain one central chiral phosphorus atom. The ttparent" tridentate phosphine is (2- diphenylphosphinoethyl)(3-diphenylphosphinopropyl) phenylphosphine, Ph2P(CH2)3PPh(CH2)2PPh2, "eptp". Other tridentates were prepared by …
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Estrogen Receptor Subtype Selective Ligands
… of several groups of non-steroidal ligands that show pronounced subtype-selective differences in ligand binding and transactivation potency or efficacy, the study of the structure-function relationships, and the molecular basis for the subtype-selective action. A …
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Synthesis of novel phosphine ligands
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1995.
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Interactions Between Heme-Globins and Ligands
Neuroglobin (Ngb) is a hexacoordinated heme protein closely related to the pentacoordinated hemoglobin (Hb) and myoglobin (Mb) and in the central and peripheral nervous systems with expression in some endocrine tissues.1–5 Ngb is believed to play roles in: sustaining ATP production under anaerobic …
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Characterisation of novel alpha1-adrenoceptor ligands
… a negative allosteric modulator of orthosteric ligands of the α1A-AR. The allosteric site was shown by docking of 4-aminoquinoline, C9, C10 and C11 to be composed of S832.61, F862.64 and E872.65, located on the extracellular part of transmembrane helix II. In further support of this region’s …
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Tetraazamacrocyclic ligands and their copper complexes
… the benzene rings were prepared. For the diimine ligands of this type both cationic and neutral copper(II) complexes were isolated and characterised; (the latter type result from loss of anilino protons on complex formation.) Compounds which are structurally related to the above …
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New alkylpiperazines as 5-HT7R ligands
Il recettore 5-HT7 è l’ultimo membro della famiglia dei recettori della serotonina, fu clonato e identificato per la prima volta nel 1993 e appartiene alla superfamiglia dei recettori accoppiati a proteina G. Lo splicing alternativo del gene che codifica per il recettore 5-HT7 genera isoforme …
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Pin1 Catalytic and WW Domain Ligands
… synthesize combinatorial libraries. To identify ligands for the Pin1 WW domain, a library, R1CO–pSer–Pro–NHR2, was designed. A new solid-phase phosphorylating reagent (SPPR) containing a phosphoramidite function was synthesized in one step from commercially available Wang resin. The SPPR was …
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Transition metal complexes of pentadentate ligands
… SALUAES, as pentadentate ligands is logical in that they offer an analogy to the environment around the cobalt atom in Vitamin B₁₂, I [see Figure I], represented below. These complexes might be expected to give some insight as to the behavior and role of the metal ion as it …
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Synthesis of P-Stereogenic Bisphosphine Ligands: Application as Hemi-labile Ligands in the Asymmetric Pauson-Khand Reaction
The synthesis of new P-stereogenic ligands and investigation of their use in a Co-catalysed asymmetric Pauson-Khand reaction has been carried out. The ligands were synthesised by asymmetric lithiation of a phosphine sulfide or a phosphine borane using alkyllithium/()-sparteine complexes, trapping …
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Novel Bifunctional Ligands For Neuropathic Pain: Design and Synthesis of Overlapping Pharmacophores of Opioid and Melanocortin Ligands
… as a therapeutic target. MC4R based agonist ligands produce anti-opioid effects, and researchers have shown that an antagonist of the MC4R can produce pronounced anti-allodynic effect. Opioid receptors have been the central and most efficacious targets sought after for relieving neuropathic …
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“CLICKED” BIVALENT MULTIFUNCTIONAL LIGANDS IN ALZHEIMER’S DISEASE.
… the therapeutic potential of multifunctional ligands that tackle various risk factors simultaneously as effective AD-modifying agents. This notion is further supported by the fact that while numerous AD-modifying agents targeting one single risk factor have been developed and a number of them …
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