Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 152 for “"knockout mouse"”.
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Functional Study of Hemogen Knockout Mouse Model
<p>Mouse Hemogen (Hemgn) is regarded as a homologue of human Erythroid Differentiation Associated Gene (EDAG). EDAG overexpression has been postulated for association with some leukemia cases. Meanwhile, Hemgn has been found to contribute to Hoxb4 mediated hematopoietic stem cell expansion. Based …
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Learning and cemory in the cav1.2 knockout mouse
… of Morris water maze experiments were performed. Knockout mice showed no deficits in short-term (24-hr) memory trials; however, on a 30-day memory probe, knockout mice performed significantly more poorly than their littermate controls. These results indicate the importance of forebrainspecific …
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Developmental Deregulation and Tumorigenesis Inhibition In 14-3-3Zeta Knockout Mouse
… I generated a strong 14-3-3z hypomorphic mutant mouse model by Gene Trap. We found that the homozygous mutant mice are lethal neonatally due to respiratory failure. This lethality could be rescued when outbred to CD-1 or backcrossed to FVB/N mouse strain.</p> <p>Early mammary gland development …
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Impaired and enhanced spatial representation of the PSD-95 knockout mouse
… factors involved with synaptic transmission. A mouse whose wildtype gene was replaced with truncation mutant of PSD-95 preserving two PDZ binding domains causes a spatial learning and memory deficit and a dramatic enhancement of synaptic strengthening. Long Term Potentiation is enhanced at all …
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The KATP -Knockout Mouse: A Model of Susceptibility to Post-Concussion Syndrome
… to poor neurological outcomes, the Kir6.2-knockout mouse. We conducted multiple behavioral tests and analyzed the cellular stress response through assessment of heat shock protein (Hsps) gene expression. We hypothesized that following mTBI, Kir6.2-knockout mice would have increased …
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Generation of focal Depdc5 knockout mouse model and implications for focal epilepsy
… virus (AAV) mediated focal cortical Depdc5 knockout mouse model. Viral vectors containing either 2/8AAV-Cre or control 2/8AAV-GFP were injected into the unilateral motor cortex of postnatal day zero or day one Depdc5 floxed (Depdc5c/c or Depdc5c/-) mouse pups. We confirmed a significant …
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Biochemical and genetic analysis of the adaptor protein SH3P7 : insights from a newly generated knockout mouse
… and endocytosis. To inactivate the mouse sh3p7 gene, the gene was first cloned and characterized. This allowed the construction of a deletion vector, which was used to target the sh3p7 gene in embryonic stem cells. Sh3p7-/- mice were successfully produced and are viable and fertile. …
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A vitamin D enriched diet attenuates sex-specific behavioral deficits in the NS-Pten knockout mouse.
… The neural subset-specific (NS) Pten knockout (KO) mouse has shown autistic-like deficits and has a lower bone mineral density. We examined the effect of a vitamin D enriched diet in the NS-Pten KO mouse. Results indicated that a vitamin D diet attenuated altered activity levels in …
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Dietary protein ameliorates goblet cell loss and modifies inflammatory responses in the colon of hnRNPI knockout mouse
… Transgenic mice with hnRNPI specifically knockout in intestinal epithelial cells (IECs) develop spontaneous colitis at an early age. Moderate dietary protein has been demonstrated to exert beneficial effects for individuals with colitis, however, mechanisms of how dietary protein impacts …
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Role of 11β-hydroxysteroid dehydrogenase type 2 in protection against inflammation during atherogenesis: studies in the Apoe-/- /11β-HSD2-/- double knockout mouse.
… Consistent with this, Apoe-/-/11β-HSD2-/- double knockout (DKO) mice show accelerated atheroma development. The present thesis tested the hypothesis that inactivation of 11β-HSD2, allowing inappropriate activation of MR in cells of the vasculature, accelerates atherogenesis through promotion of a …
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Investigation of Sensory Cell-Specific Changes in Gene Expression in Microrna-183 Family Knockout Mouse Inner Ear From Bulk RNA Sequencing Analysis
… conducted bulk RNA sequencing to compare newborn mouse inner ear tissues from wild-type versus miR-183 family knockout (KO) mice. Bulk RNA sequencing revealed numerous gene expression changes in the cochlear sensory epithelium and spiral ganglion due to miR-183 family loss-of-function. However, …
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Characterization of the brain as a site of fructose metabolism and of an aldolase B knockout mouse that mimics human hereditary fructose intolerance
… in the aldolase B gene (ALDOB, human; Aldo2, mouse). With low levels of fructose exposure, HFI patients develop NAFLD and liver fibrosis, sharing pathologies with MBS. Targeting Aldo2 for deletion in mice (Aldo2-/-) provides a major step in validating that fructose metabolism in mice mimics …
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Defining the Role of Pannexin1 in Skeletal Muscle and Satellite Cell Function in vivo and ex vivo Using a Novel Conditional Knockout Mouse Model
… Using a novel skeletal-muscle-specific Panx1 knockout (Panx1^smKO) mouse model, this thesis highlights the influences Panx1 plays in muscular development and maintenance, as well as in muscle function. Loss of Panx1 led to a fiber-type switch coinciding with smaller fibers in both the tibialis …
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Mice Lacking Delta -6 Desaturase Provide New Insight Into the Essentiality of Highly Unsaturated Fatty Acids
This knockout mouse presents itself as an ideal model for the continued investigation of HUFA including AA, DHA and DPA.
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Characterization of Cre Mouse Models to Target CNS Barriers for Generating Conditional Knockouts of ABC Transporters
… and have been studied using global transporter knockout mouse models. Since the CNS compartment and location of transporters is unique at each barrier site, a global knockout model does not address questions of how each barrier site contributes to ineffectiveness of drugs getting into the CNS. …
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Neurochemical Measurements in Rodents that Model Huntingtion's Disease and Oxidative Stress
… to the increased dopamine levels of this knockout mouse. The results suggest that dopamine in reserve pool vesicles accumulates in the MrsA knockout mouse. This evidence supports previous reports that suggest the amount of dopamine in reserve pools is dependent on the overall dopamine …
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DAPK3 Suppresses Mammary Acini Morphogenesis and is Required for Mouse Development
… physiological roles in vivo due to the lack of knockout animals. To address these gaps in our fundamental understanding of DAPK3 we</p><p>utilized the MCF10A 3D tumorigenesis model in vitro and generated a constitutive DAPK3 knockout mouse. Using the MCF10A 3D morphogenesis model we identified …
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THE ROLE OF THE TRANSCRIPTION FACTOR DEAF-1 IN PROSTATE FUNCTION
… out mice were generated using conventional gene knockout methods to study the standard null phenotype. Deaf-1 is necessary for neural tube development and 68% of Deaf-1 null mice embryos show excencephaly. Loss of Deaf-1 is associated with decreased apoptotic response in knockout mouse embryo …
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유전자 적중법을 이용한 조건적 LDHB 유전자 삭제 마우스 제작
… vector about LDHB gene used by LDHB genome(mouse). And then, this targeting vector insert into the ES cell. Then targeted ES cell inject into blastocyst. As a result, we have got the chimera, LDHB targeted mouse. And now, we have gained the LDHB knockout mouse that generated by mating LDHB …
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The role of circadian rhythms in reproduction: development and fertility in the bmal1 null mouse.
… including reduction of fertility. The bmal1 mouse provides an animal model for central and peripheral loss of rhythmicity. Herein the reproductive function and postnatal development in the bmal1 knockout mouse has been evaluated. The reproductive capability of the heterozygous breeding colony …
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