Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 221 for “"intraperitoneal"”.
-
Sustained-release implants for intraperitoneal cisplatin delivery
… directly into the abdomen, also known as intraperitoneal (IP) chemotherapy. IP chemotherapy can help treat peritoneal metastasis in many advanced gynecologic and gastrointestinal cancers and has shown particular promise in treating advanced ovarian cancer. It is however tremendously …
-
NANOPARTICLE DEPOT FOR INTRAPERITONEAL CHEMOTHERAPY OF OVARIAN CANCER
Intraperitoneal (IP) chemotherapy is a promising post-surgical therapy of ovarian cancer, with the full potential yet to be proven. To facilitate IP chemotherapy of ovarian cancer, we have developed a nanoparticle depot for IP chemotherapy consisted of paclitaxel (PTX) nanocrystals (PNC) and …
-
Drug delivery of paclitaxel for an intraperitoneal chemotherapy
… a high mortality. In recent years, hyperthermic intraperitoneal chemotherapy (HIPEC) after cytoreductive surgery has been introduced as an alternative treatment. An interesting drug for HIPEC is paclitaxel. However, the use of paclitaxel is hampered by its poor solubility and the currently used …
-
Chemotherapy-Eluting Intraperitoneal Implants for Advanced Stage Ovarian Cancer Treatment
… for sustained abdominal chemotherapy delivery, intraperitoneal (IP) chemotherapy. IP chemotherapy has improved survival in ovarian cancer (OC) patients, but its adoption has suffered due to resource requirements and dose-limiting toxicities. We previously showed that an IP device that delivers …
-
An investigation of intraperitoneal procaine penicillin G administration in lactating dairy cows
… profile of procaine penicillin G after intraperitoneal (IP) administration in 8 lactating dairy cows. Procaine pencillin G (PPG, 21,000 IU/kg) was deposited into the abdominal cavity of each cow following an incision in the right paralumbar fossa. Blood and milk samples were taken over …
-
Design of an intraperitoneal drug-release device for advanced ovarian cancer therapy
… followed by adjuvant chemotherapy. Combination intraperitoneal (IP) and intravenous (IV) chemotherapy has been shown to lengthen survival over IV therapy alone. Large-volume infusions, drug-associated toxicity, and catheter-associated complications, however, increase morbidity and limit patient …
-
An intraperitoneal implantable drug delivery device for the treatment of ovarian cancer
… surgery, followed by intravenous (IV) or intraperitoneal (IP) chemotherapy with cisplatin and taxol. Clinical trials showed that the IP cisplatin treatment regimen was able to prolong overall survival by 16 months but only 42% of subjects completed all cycles of the IP therapy. The primary …
-
Biodistribution Studies of 64Cu-DOTA-Cetuximab after Intraperitoneal and Intravenous Injection in a Malignant Ascites Mouse Model of Human Gastric Carcinoma
Intraperitoneal (i.p.) radioimmunotherapy (RIT) may be a promising treatment strategy for intraperitoneally-confined malignant diseases including malignant ascites (MA) in gastric cancer. We conducted a comparative biodistribution study of 64Cu-DOTAcetuximab in subcutaneous (SQ) tumor and MA mouse …
-
Management of civilian penetrating rectal injuries in an urban trauma centre
… complications and mortality were noted. Intraperitoneal rectal injuries were primarily repaired, with or without faecal diversion. Extraperitoneal rectal injuries were generally left untouched, and a diverting loop colostomy done. Intraperitoneal bladder injuries were primarily repaired …
-
Immunoisolation Approaches for Islet Transplantation
… device which are typically implanted intraperitoneally. Intraperitoneal microencapsulated islet grafts are suboptimal, requiring at least double the number of islets to reverse hyperglycaemia compared to non-encapsulated islet grafts. The large size of microencapsulated islet grafts …
-
Estudio de dos modelos de alcoholización en ratas adolescentes sobre el selenio y los sistemas de defensa antioxidante. Proyección a pacientes alcohólicos crónicos
… por vía oral, más fisiológico, y otro por vía intraperitoneal, más utilizado por los investigadores. Ambos modelos reprodujeron el patrón de consumo tipo "botellón" o "binge drinking" (en término anglosajón). Los animales se distribuyeron en cuatro grupos experimentales, denominados grupo …
-
Aetiologie, Klinik und Prognose bei männlichen Rindern mit Harnröhrenverschluss
… urinary bladder or subcutaneous oedema or intraperitoneal urine accumulation are considered to be diagnostic. Not only the parameters of the special but also of the general physical examination turned out to be important in the evaluation of the stage of the disease and the detection of …
-
ANAESTHESIA AND PAIN MANAGEMENT IN COMPANION ANIMALS
… facet of small animals clinical practice. Intraperitoneal and intra-articular administration of analgesic drugs are two alternative, simple and low-cost techniques for perioperative pain management in small animal practice. Based on the results obtained in the first study of this PhD …
-
Relative allergenicity of modified bovine milk proteins
… to the test proteins using separate oral and intraperitoneal experimental protocols. In addition, an enzyme linked immunosorbent assay (ELISA) was used to determine the relative concentrations of antigen specific immunoglobulins G and E in the antisera. Mice which received the test proteins by …
-
Estudo comparativo do efeito de warifteína e metil-warifteína, alcaloides de Cissamplelos sympodialis ECHL (Menispermaceae), no processo inflamatório agudo.
… . The vascular permeability was assessed by intraperitoneal injection of acetic acid, and protein concentrations were quantified spectrophotometrically using Evans blue . The cell migration was assessed by intraperitoneal injection of zymosan , with consequent peritoneal lavage and cell …
-
TARGETED POLYMER NANOPARTICLES FOR THE DETECTION AND TREATMENT OF DISSEMINATED COLORECTAL CANCER IN VIVO
… to treat by conventional methods. Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in combination with cytoreductive surgery (CRS) has improved the 5-year survival rate of late-stage CRC patients from 12% to 51%. However, the survival rates of these patients have stagnated, which emphasizes the …
-
Pancreatite aguda experimental induzida pela L-Arginina : avaliação bioquímica e histológica
… grupo experimento (n=70) administrou-se injeção intraperitoneal de 500mg/100g de peso corporal de L-Arginina dividida em doses iguais e injetada em duas etapas com intervalos de 15 minutos. No grupo controle (n=35), foi injetado solução salina isotônica por via intraperitoneal. Foram analisados …
-
The role of the inositol phosphatase, SHIP, in the innate immune response to Salmonella Typhimurium
… an increased susceptibility to both oral and intraperitoneal S. Typhimurium infection and had significantly higher bacterial loads in intestinal and systemic sites than ship⁺/⁺mice, indicating a role for SHIP in the gut and systemic pathogenesis of S. Typhimurium in vivo. Blood cytokine levels …
Page 1 of 12