Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 78 for “"interneuron"”.
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Ephrin Receptors, AIY Interneuron Physiology, and Behavior
… its sensory neurons is processed via a pair of interneurons called AIYL and AIYR. In wild-type animals, the AIY cell bodies lie just posterior to the pharynx, and extend an anterior process that contacts its contralateral partner at the base of the nerve ring. The AIYL and R processes then …
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Contributions of distinct interneuron types to neocortical dynamics
Inhibitory interneurons are thought to play a crucial role in several features of neocortical processing, including dynamics on the timescale of milliseconds. Their anatomical and physiological characteristics are diverse, suggesting that different types regulate distinct aspects of neocortical …
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Investigation of Accessory Olfactory Interneuron Physiology and Function After Experience-Dependent Plasticity
… female mice after social experience. In the AOB, interneurons called internal granule cells (IGCs) express the plasticity-associated immediate-early gene Arc following intermale aggression or mating. Here, I sought to understand how Arc-expressing IGCs shape AOB information processing and social …
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Shaping of Spike-Timing-Dependent Plasticity curve using interneuron and calcium dynamics
The field of Computational Neuroscience is where neuroscience and computational modelling merge together. It is an ever-emerging area of research where the level of biological modelling can range from small-scale cellular models, to the larger network scale models. This MSc Thesis will detail the …
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Inhibition, Synapses, and Spike-Timing: Identification and disruption of pyramidal cell-interneuron interactions in SPW-Rs
… excitatory pyramidal cells and inhibitory interneurons shape ensemble activity which encodes sequential experience. An extremely diverse set of inhibitory interneurons, with variation in gene expression, synaptic targeting, state-dependent activity, and connectivity, contribute …
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INTERNEURON TRANSPLANTS AS A TREATMENT FOR SEIZURES AND SOCIAL DEFICITS IN A MOUSE MODEL OF DRAVET SYNDROME
GABAergic inhibitory interneuron transplants have been shown to ameliorate seizures and epilepsy-associated behavioral deficits in several preclinical rodent models of epilepsy. These studies have generally focused on focal temporal epilepsy models, but less is understood about the efficacy of …
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Interneuron networks and cortical dynamics : emulated whisking drives SOM interneurons in the ketamine anesthetized mouse SI neocortex
… confirm the hypothesis that separate classes of interneurons respond differentially to sensory stimulation independent of volitional or other top-down control on the part of the animal. I also test and confirm the hypothesis that, based only on bottom-up sensory stimulation the activity of two …
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Classification of Neuronal Nicotinic Acetylcholine Receptors in Rat CA1 Hippocampal Interneuron Subpopulations Defined by Calcium-Binding Protein mRNA Expression
… (alpha2-alpha5, alpha7, beta2-beta4) from interneurons from the stratum radiatum or stratum oriens within the CA1 region of rat hippocampi was analyzed using quantitative real time RT-PCR. Eighty-seven percent of the interneurons examined expressed CaBP mRNA. Parvalbumin mRNA was detected …
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Die Rolle der Synaptische Kurzzeitplastizität im neuronale Schaltkreise
… aus einer exzitatorischen Eingangssynapse, einem Interneuron und einer inhibitorischen Ausgangssynapse. In dieser Arbeit betrachten wir gleichzeitig zwei solche inhibitorische Schaltkreise im Kleinhirn mit dem Ziel, die Dynamik der Eingangs- und Ausgangssynapsen, die intrinsischen …
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Characterization of an Inhibitory Pathway to Feeding Command Neurons in the Brain of Pleurobranchaea Californica and an Analysis of the Changes in This Pathway That Occur as a Result of Food-Avoidance Conditioning
… pathway consists of 3 serially connected interneurons. The first population, the Interneuron 1s (Int-1s), mono-synaptically inhibits the PCNs. A second population, the Interneuron 2s (Int-2s) excite the Int-1s. A third population, the Interneuron 3s (Int-3s), mono-synaptically excites the …
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Genetic Functional Dissection of the Synaptic Output of a Dual-Function Integrating Neuron
… over time. This thesis focuses on a single interneuron, RIM, and a single behavior, the reversal, to better understand how the circuits driving motor outputs accomplish the seemingly contradictory tasks of generating appropriate and variable behaviors. In the compact and well-defined nervous …
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The Diversity of Cortical Interneurons
… and memory consolidation. The cortical interneurons are key elements of the cortical system. These interneurons stabilize networks, but at the same time they also add non-linear effects to the excitatory system to make the cortical network more dynamic. To achieve this, cortical …
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Behavioural and Metabolic Characterization of NPR-9 and AIB Signaling Dynamics in Caenorhabditis Elegans
… neurons, integrate sensory evoked signals via interneurons, and modulate downstream pathways dependent on environmental context. Internal cues, such as a well fed or starved condition, can also reconfigure the neural circuitry. Interneuron AIB functions as an integration hub that integrates …
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The Role of Pax3 in Neuronal Differentiation of the Ophthalmic (OpV) Trigeminal Placode and Neural Tube during Chicken Embryonic Development
… in the restriction and differentiation of dorsal interneuron progenitors has been difficult to assess due to the many additional factors involved in specification and patterning of the neural tube. We have used electroporation in the chick model system to ectopically express Pax3 and Pax7 …
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The Role of PTF1A in Spinal Cord Development
… (dI4, E10.5) and late born (dILA, E12.5) dorsal interneuron populations identified by homeodomain factors Lhx1/5 and Pax2. Furthermore, in the absence of PTF1a, the dI4 dorsal interneurons trans-fate to dI5 (Lmx1b+), and the dILA to dILB (Lmx1b+;Tlx3+). This mis-specification of neurons results …
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Developing High Purity Embryonic Stem Cell-Derived V2a Interneurons for In Vitro Investigation and Transplantation Following Spinal Cord Injury
… has been attributed to plasticity in local interneuron populations, which are able to create novel circuits that bypass the inhibitory lesion to activate pre-existing motor pathways. Cell replacement strategies and growth factor delivery platforms often attempt to enhance these natural …
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Entwicklung eines strukturtreuen passiven Kabelleitermodells eines inhibitorischen Interneurons im Gyrus Dentatus des Hippokampus der Ratte
… kurze und lange Strompulse von Interneuronen im Gyrus dentatus des Hippokampus der Ratte gemessen, die gleichzeitig mit Biocytin gefüllt und anschließend histologisch entwickelt wurden. Ein einzelnes Interneuron wurde aufgrund verschiedener Qualitätskriterien für die Entwicklung …
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Validating ngn-1 transcriptome targets in C. elegans
… whereas <em>glr-6</em> is expressed in the RIA interneuron. Preliminary data reveals that <em>ngn-1</em> is required for correct sensory neuron morphology and may have a role in fate determination of the RIA interneuron. Together, these data add further evidence that <em>ngn-1</em> functions …
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Transcription factor Pax6 protects mouse cortical cell fate specification
… and use glutamate as the main neurotransmitter. Interneurons are mostly GABAergic and use GABA as their main neurotransmitter. PCs are the output units of the cortex and comprise ~80-85% of the mouse cortex. Interneurons modulate the activity of PCs and comprise ~20-15% of the mouse cortex. These …
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Neural Circuit Dependence of Acute and Subacute Nociception in C. Elegans
… neurons that is connected by a single class of interneuron, bypassing the higher processing centers. Both neural circuits also feature higher processing pathways that receive information from sensory neurons and provide further input onto the direct pathway. While the anatomical wiring of the C. …
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