Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 429 for “"integrin"”.
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Integrin-targeted cancer immunotherapy
Integrins are a family of heterodimeric cell surface receptors that are functionally important for cell adhesion, migration and proliferation. Certain integrins, especially those that are known to recognize the arginine-glycine-aspartate (RGD) motif, are heavily overexpressed in many cancers …
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Integrin alpha6beta4 contributions in pancreatic adenocarcinoma
… dissertation, I determined how the pro-invasive integrin alpha6beta4 expression was related to pancreatic adenocarcinoma tumor progression in tumor samples and assessed in-vitro if the expression of this integrin was required for the migration and invasion of pancreatic cancer cells. In addition, …
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Integrin α2 and Akt in early hematopoiesis
… stem and progenitor cells still far lags behind. Integrins are heterodimeric transmembrane protein receptors regulating many important cellular processes including homing of HSCs by binding to neighboring cells or extracellular matrix proteins. First, we showed that integrin α2 is a novel marker …
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The α7β1 integrin accelerates exercise-induced myogenesis
… transgenic overexpression of the α7β1 integrin can protect against exercise induced-injury and promote the appearance of multipotent mesenchymal-like (Sca-1+CD45-) stem cells in skeletal muscle. PURPOSE: The purpose of this study was to determine if overexpression of the α7β1 integrin …
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Integrin-vermittelte Invasion von Staphylococcus aureus in Säugerzellen
… und dem Fn-Rezeptor auf der Wirtszellseite, dem Integrin 51, dienen. Neben der Anheftung an das Wirtsgewebe kann die indirekte Assoziation mit Integrin 51 die Aufnahme der Bakterien durch die eukaryontische Zelle auslösen. Wie die bakterielle Adhäsion an Integrin 51 und die Aggregation der …
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Signaling of integrin lower leg and transmembrane domains
Integrin conformational changes mediate integrin activation and signaling triggered by intracellular molecules or extracellular ligands. Even though it has been shown that TM and/or cytoplasmic α and β domains associate in the resting state and separation of these domains is required for integrin …
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Regulation of Cell Migration by Integrin -Mediated Adhesion
… identifying new molecules involved in regulating integrin-mediated adhesion during cell migration. The technique of mammalian cDNA expression cloning was used to identify regulators of cell-substratum adhesion. Through this approach, a cDNA with homology to RACK1, a receptor for activated protein …
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An Alpha7beta1 Integrin-Based Treatment of Muscular Dystrophy
… in adult skeletal muscles are the alpha7beta1 integrin complex and the dystrophin protein complex. Both act as molecular chains that connect the actin cytoskeleton to laminin in the basal lamina. Disruption of either linkage system leads to muscular dystrophy in humans and mice. To determine if …
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Integrin Alpha Subunit Expression and Cytoplasmic Domain Function
The $\beta\sb1$ integrins are a family of $\alpha\beta$ heterodimeric cell surface receptors which mediate cell adhesion to molecules of the extracellular matrix (ECM), and also span the membrane and associate with the cytoskeleton via their cytoplasmic domains. By mediating the interaction of the …
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Regulation of integrin-mediated linkages during cell migration
The objective of this study was to determine how integrin adhesion interact with both cytoskeletal elements and ligands to determine cell migration speed. An understanding of these parameters will aid in developing methods to control cell migration to treat diseases such as cancer, to aid wound …
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Characterization of proteins purified from a beta(1) integrin affinity column: A novel ecm molecule and a muscle-specific integrin alpha subunit
Previous work on the distribution of the $\beta$1 integrins on skeletal muscle revealed that integrin occupied all of the major junctional regions on muscle. It also showed interesting, anomalous proteins on SDS-PAGE from $\beta$1 affinity purifications from muscle tissue. The possibility that …
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Analysis of Β8 Integrin In Neurogenesis and Neurovascular Homeostasis
… have shown that loss of the ECM receptor, αvβ8 integrin, in NSCs in the embryonic mouse brain leads to severe developmental vascular defects and premature death. Here, the functions of αvβ8 integrin in the adult brain have been examined using mice that have been genetically manipulated to lack a …
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Integrin-ligand interactions and cytokine production by monocytic cells
… Soluble CD23 also interacts with members of the integrin family of membrane receptors. Integrins are heterodimeric transmembrane receptors that participate in bidirectional signalling across membranes and have a critical role in cellular adhesion reactions. CD23 interacts with four integrins, …
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The membrane lipid composition regulates talin mediated integrin activation
Integrins are a family of transmembrane receptors that mediate cell-cell and cell-extra cellular matrix (ECM) interaction and signaling. Inside-out activation of integrin receptors often requires the binding of the cytoplasmic domain of the subunits by talin. This interaction leads to separation of …
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The Alpha7beta1 Integrin in Skeletal Muscle and Muscular Dystrophy
… thesis examines the effects of enhancing alpha7 integrin on cellular functions and global gene expression in myoblasts and skeletal muscle. I found that 3-fold more alpha7 integrin promotes myoblast adhesion, proliferation and resistance to apoptosis without affecting differentiation. In …
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Analyzing The Role of Αvβ8 Integrin In Glioma-Induced Angiogenesis
… aimed to determine the functional roles for αvβ8 integrin in astrocytoma-induced angiogenesis. These studies originate from our analyses of αvβ8 integrin in developmental brain angiogenesis. αv and β8 knockout (KO) mice develop brain-specific vascular phenotypes that resemble vascular pathologies …
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Th17 Cell Pathogenicity Promoted by Integrin α3 During Autoimmune Neuroinflammation
… Th17 cell migration. Here, we report integrin α3 as a Th17 cell-selective determinant of pathogenicity in experimental autoimmune encephalomyelitis, a mouse model of MS. CNS-infiltrating Th17 cells express high integrin α3, the expression of which is induced by transcription factors …
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Molecular Enhancement of Alpha 7 Integrin to Ameliorate Muscular Dystrophy
… cytoskeleton in skeletal muscle. The alpha7beta1 integrin also links laminin in the extracellular matrix to actin in skeletal muscle. It has been shown that transgenic overexpression of the alpha7 integrin chain in mdx/utr (-/-) mice, a model for Duchenne muscular dystrophy, ameliorates dystrophic …
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