Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 142 for “"infarct"”.
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Effect of Rat Strain Stereotactic Coordinates on Infarct Volume
… Long Evans rats sustain a significantly larger infarct volume compared to Sprague Dawley rats using Group 2 coordinates; Group 1 cortical injection coordinates produced a larger infarct than Group 2 coordinates in FSA Sprague Dawley rats; drug treatment showed no effect on total infarct volume, …
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The time course of healing of myocardial infarct in pigs.
Abstract Not Available.
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The use of biomaterials for stem cell therapies to prevent myocardial damage post-infarct
… of damaged heart tissue following a myocardial infarction. While current medical practices to address the immediate aftermath of a myocardial infarction (MI) have evolved tremendously, there are few, if any, techniques currently administered to slow, cease, or reverse the negative side effects …
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Infarct size and free fatty acids in the early phase of acute myocardial infarction
The management of acute myocardial infarction (AMI) has been improved by the realisation that the size of infarction can influence mortality (Sobel et al, 1972) and that the infarct size can be altered by subsequent therapy (Maroko et al, 1972). The identification of any factor which may have …
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A computational study of post-infarct mechanical effects of injected biomaterial into ischaemic myocardium
… ischaemic heart disease, involving a myocardial infarction (MI). Emerging MI therapies involving biomaterial injections have shown some benefits; the underlying mechanisms of which remain unclear. Computational models offer considerable potential to study the biomechanics of a myocardial …
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Imaging Post-Infarct Myocardial Inflammation with ⁶⁸Ga-DOTATATE PET/MRI and insights into COVID-19 associated myocardial injury
i) Post-Infarct Myocardial Inflammation and Imaging Background: Inflammation and its resolution modulate post-infarct myocardial injury. An excessive or prolonged inflammatory phase after myocardial infarction (MI) may contribute to adverse cardiac remodelling. <sup>68</sup>Ga-DOTATATE is a PET …
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Acute Myocardial Infarction: The Relationship between Duration of Ischaemia and Infarct Size in Humans - Assessment by MRI and SPECT
The effect of duration of ischaemia on final infarct size is well established in animal studies, but not fully evaluated in humans. Delayed contrast-enhanced magnetic resonance imaging (DE-MRI) can be used to distinguish between viable and non-viable myocardium and thus to quantify infarct size. We …
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INVESTIGATION OF GENETIC FACTORS DETERMINING ISCHEMIC STROKE OUTCOME
… factors of ischemic stroke outcome measured by infarct volume. This model is the middle cerebral artery occlusion (MCAO) model. First, we screened infarct volumes across 32 inbred mouse strains. The infarct volume varies between strains, and this strongly suggests that infarct volume is …
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Quantitative assessment of myocardial infarction: On the relationship between anatomy and electrophysiology using MRI and ECG
Both presence and extent of myocardial infarction are important prognostic factors for mortality and quality of life in patients with ischemic heart disease. Thus, it is of great clinical importance to be able to diagnose and characterize myocardial infarction. One way to diagnose myocardial …
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Computational biomechanics of acute myocardial infarction and its treatment
… is an emerging therapy for myocardial infarction. Computational methods can help to study the mechanical effect s of biomaterial injectates on the infarcted heart s and can contribute to advance and optimise the concept of this therapy. The distribution of polyethylene glycol hydrogel …
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Dysfunctional but viable myocardium - ischemic heart disease assessed by magnetic resonance imaging and single photon emission computed tomography
… that wall thickening decreases with increasing infarct transmurality. However, the variation in wall thickening was large, and importantly, influenced more so by the function of adjacent myocardium than by infarct transmurality. This underscores the difficulty of using resting function alone to …
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Hypothermia as an adjunctive therapy in Acute Myocardial Infarction and Cardiogenic Shock
… patients with an ongoing ST-elevation myocardial infarction (STEMI) is to re-establish coronary flow in the epicardial arteries as soon as possible in order to reduce infarct size and associated complications. Hypothermia has in experimental studies been shown to reduce infarct size. Clinical …
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Schnelle und akkurate Bestimmung der relativen Infarktgröße am Menschen durch kontrastmittelverstärkte Magnet-Resonanz-Tomographie im Vergleich mit der F-Fluorodesoxyglukose-Positronen-Emissions-Tomographie
… study were to compare in humans in-vivo relative infarct size measurements with contrast enhanced magnetic resonance imaging (ceMRI) using 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) as a reference standard (first part) and to quantify relative infarct sizing using semi-automatic …
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Repeated full dose thrombolysis in patients hospitalised with myocardial infarction : safety and efficacy
The treatment and outcome myocardial infarction has been revolutionised by the demonstration that thrombolytic grugs can open the infarct-related arterty, salvage ischaemic myocardium, preserve left ventricular function and save lives. However, thrombolytic drugs are not uniformly effective in …
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Effekt einer transendokardialen kathetergestützten Applikation von Stromal cell derived factor 1[alpha] auf die linksventrikuläre Funktion im Herzinfarktmodell im Schwein
… function in a porcine model of myocardial infarction. In domestic pigs myocardial infarction was induced via microembolization of the distal left anterior descending artery. Catheter-based transendocardial injection of SDF-1alpha into the infarct and periinfarct myocardium was performed two …
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The Cannabinoid-2 Receptor Agonist O-1966 Reverses Postischemic Learning and Memory Deficits Through Anti-Inflammatory Processes
… within a thin therapeutic window of the initial infarct. This requirement results in less than 10% of stroke patients being eligible for treatment. There are currently no treatment options that are effective in the subacute phase of the disease and no treatments that are effective in reversing …
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fMRI assessment of ischemic stroke in humans
… tissue. There are two major injury regions: the infarct and penumbra. Mostly, since the infarct regions became dead tissues rapidly after stroke, there is a tiny possibility to rescue them in time. But penumbra parts are different. Tissues there will be viable for hours after ischemia. Hence, …
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Papildomas adenozino vaidmuo mažinant infarkto dydį ir išsaugant kairiojo skilvelio funkciją pacientams, sergantiems ūminiu miokardo infarktu /
… intervention, i.e. PCI), role in reducing the infarct size and preserving the left ventricular function in patients with acute myocardial infarction. During the study we examined patients with the left ventricular anterior wall acute myocardial infarction (AMI), when PCI and stenting were used …
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Determining the role of the LPI/GPR55 system in the development of obesity and associated cardiovascular consequences.
… knockout and HFD intervention on the myocardial infarct size sustained following a period of ischaemia/reperfusion (I/R) and 3) make use of an in vitro model to elucidate the mechanisms by which changes occur in the adipose tissue of mice fed a HFD. GPR55-/- mice fed a HFD for 12-weeks gained …
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Quantitative and Qualitative Assessment of the Myocardium at Risk
One of the major determinants of the final infarct size during an acute coronary occlusion is the size of the myocardium subjected to ischemia. Identification and quantification of this so-called myocardium at risk in the acute phase of ischemia has been difficult in patients with conventional …
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