Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"hyperinsulinemia"”.
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Cellular Mechanisms Involved in Reactive Carbonyl and Hyperinsulinemia Enhancement of Diabetic Complications
The findings in this thesis demonstrate that (1) hyperinsulinemia negatively impacts B-cell survival (2) and impairs the anti-inflammatory actions of IL-4 in macrophages and finally (3) the reactive carbonyl methylglyoxal enhances chemotherapeutic drug-dependent cytotoxicity. We report that …
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Hyperinsulinemia and Hyperglycemia Contribute to Diabetic Complications Through Cytokine Resistance and Altered Macrophage Function
… association between two hallmarks of type 2 DM, hyperinsulinemia and hyperglycemia, and the conditions pertinent to the development of diabetes-accelerated atherosclerosis. Chapters 2 through 4 establish that (1) the rapamycin pathway plays an integral role in serine phosphorylation dependent …
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DIETARY INTERVENTIONS TARGETING GLUCOSE METABOLISM AND HYPERINSULINEMIA: A NEW TRANSLATIONAL PERSPECTIVE FOR THE MANAGEMENT OF ACUTE INTERMITTENT PORPHYRIA
… that AIP mice developed glucose intolerance and hyperinsulinemia during fasting. In this model, hepatic glycogen storages were not exploited to normalize glycemia and alternative mechanisms as ketogenesis were aberrantly activated to face with energy demand. In addition, AIP patients with …
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Regulation of Nutrient Metabolism in Equine Skeletal Muscle and Adipose Tissue
… increased fasting plasma insulin concentrations (hyperinsulinemia) while altered lipid metabolism is evidenced by increased plasma lipid concentrations. Obesity in horses also increases the risk of the painful hoof disease, laminitis. Three experiments were performed to investigate the regulation …
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The effect of an exercise intervention on insulin sensitivity, insulin secretion and insulin clearance in black obese South African women
… present with low insulin sensitivity (SI) and hyperinsulinemia, the latter due to high insulin secretion and reduced clearance. In addition, they exhibit lower levels of central and ectopic fat, compared to their white counterparts, contradicting the known correlates of SI typically reported in …
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Coupling mechanisms of insulin secretion - roles of mitochondrial metabolism and cAMP.
… in¬creasing their secretion of insulin, causing hyperinsulinemia. This state may not be a major risk factor per se; in fact, many people develop severe insulin resistance and hyperinsulinemia without ever acquiring diabetes. However, beta-cells in some individuals, perhaps genetically …
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Type 2 Diabetes Impairs Interleukin-4 Function in Macrophages and Amplifies the Brain-Based Neuroimmune Response
… degradation, (2) chronic hyperglycemia and hyperinsulinemia disrupt specific anti-inflammatory functions of IL-4 in macrophages as a result of diminished IRS-2 mediated signaling and increased SOCS-3 expression, and (3) the IL-1beta-mediated neuroimmune response is amplified in db/db mice …
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Equine obesity and its role in insulin resistance, inflammation and risk for laminitis
… pasture-associated laminitis, including hyperinsulinemia (> 32 mU/L), hyperleptinemia (> 7.3 ng/mL), and generalized (body condition score ≥ 7) and localized (cresty neck score ≥ 4) obesity. Induction of obesity in 13 Arabian geldings by 4 months of overfeeding resulted in compensated …
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THE ROLE OF NIEMANN-PICK C1-LIKE 1 (NPC1L1) PROTEIN IN CHOLESTEROL TRANSPORT AND METABOLIC DISEASES
… mice against HFD-induced insulin resistance and hyperinsulinemia, a state known to drive hepatic lipogenesis. .
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The equine metabolic syndrome: studies on the pathophysiology of obesity, insulin resistance, and laminitis in equids
… to carbohydrate challenge and accompanied hyperinsulinemia. Primary inflammatory events (including laminar inflammatory gene expression and leukocyte infiltration) were not associated with dietary carbohydrate challenge and do not appear central to EMS-associated laminitis. The purpose of …
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Insulin resistance in cancer cachexia and metabolic syndrome
… mediators. One of the main features of MetS is hyperinsulinemia, which is generally associated with an attempt of the β-cell to compensate for diminished insulin sensitivity (insulin resistance). There is growing evidence that hyperinsulinemia per se may contribute to the development of insulin …
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Determining the effect of lipid nanoemulsions on insulin signaling and the inflammatory pathways at the Blood-Brain Barrier
… huge implications for memory and cognition(2). Hyperinsulinemia observed in AD and T2DM contributes to vascular inflammation, which in turn, leads to endothelial insulin resistance by impairing insulin receptor (IR) and insulin resistance substrate (IRS)-1(1). The insulin resistance leads to a …
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The effects of insulin and the insulin-like growth factors (IGF-I and IGF-II) on the proliferation and differentiation of cells isolated from placentae of non-diabetic and diabetic subjects
Maternai peripheral hyperinsulinemia and fetal hyperinsulinism that occurs as a conséquence of the treatment of diabetic pregnancy hâve been associated with both gross and microscopic, cellular changes. Thèse include an apparent hyperplacentation and fetal macrosomia and trophoblastic …
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A Review to Critique the Literature on Polycystic Ovarian Syndrome Origins
… with hyperandrogenism, insulin resistance, and hyperinsulinemia, suggesting an interaction between glucose metabolism and the ovary. There are differing criteria established to diagnose PCOS, which complicates its diagnosis. Gene studies have not led to many conclusions regarding a genetic basis …
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Physiological consequences of exposure to heat stress and the mycotoxin zearalenone
… of interest is a heat-stress induced state of hyperinsulinemia and hypoglycemia while self-limiting feed intake. In regards to effects on feedstuffs, high ambient temperatures are associated with elevated concentrations of mycotoxins in cereal grains. Mycotoxins are problematic because, at …
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The Pathophysiological Importance of Nicotinamide Phosphoribosyltransferase as a Key NAD Biosynthesis Enzyme in Metabolic Homeostasis
… insulin secretion accompanied by hyperinsulinemia, and administration of NMN partially restores insulin sensitivity but almost completely ameliorates the responsiveness of pancreatic β cells to glucose and hyperinsulinemia in vivo. Taken together, our results suggest the new …
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Modeling “Abnormal” Ovulatory Dynamics: Enzymes, Insulin, and the Impact of Stress
… ovulatory cycle – increased aromatase activity, hyperinsulinemia, suppression of luteinizing hormone (LH), and the influence of cortisol on kisspeptin signaling. High levels of simulated chronic stress cause significant disruption of the ovulatory cycle. Investigating the impact of acute stress, …
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Genomic analysis of hepatic insulin resistance
… which results in simultaneous hyperglycemia and hyperinsulinemia. Because of the prevalence of type II diabetes, many researchers are investigating the genetics of glucose homeostasis, however, traditional mapping techniques have not been successful in determining all of the genes that regulate …
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Glucose tolerance, plasma insulin, and plasma glucagon in relation to obesity in chickens
… selected for rapid growth is associated with hyperinsulinemia and insulin resistance.
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Insulin Recepto Loss Impairs Mammary Tumourigenesis in Mice
… and the obesity-associated type 2 diabetes. Hyperinsulinemia, common in the obese state, has been associated with higher risk of death and recurrence in BC. Up to 80% of breast cancers overexpress the insulin receptor (INSR), which correlates with worse prognosis. To directly probe the role …
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