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Showing 1 to 20 of 171 for “"hsp70"”.
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Interaction of HspBP1 with Hsp70
The Hsp70 family protein members are involved in many diverse processes that are essential for cell survival. The Hsp70 cochaperones control and specify Hsp70 interactions by modifying Hsp70 activity and linking Hsp70 proteins to specific cellular processes. Understanding the mechanistic details of …
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Elucidation of the role of the linker motifs of Plasmodium falciparum Hsp70-1 and Hsp70-z
… its life cycle. Some of the parasite Hsp70 family members, amongst them, PfHsp70-1 and PfHsp70-z, are essential for parasite survival. PfHsp70-1 is a canonical Hsp70, which closely resembles Escherichia coli Hsp70, DnaK. On the other hand, PfHsp70-z is a non-canonical Hsp70 which …
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HSP70: a therapeutic biomarker for treatment of glioma
… Recently, highly inducible molecular chaperones HSP70 and HSP90 are emerging as important anti-cancer targets. Previously, proteomic analysis had demonstrated that post-induction of HSP70 on HSP90 inhibition undermines the efficacy of treatment. The present study has quantified transcriptional …
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Characterisation of the plasmodium falciparum HSP70-HSP90 organising protein
… stress linked to its life cycle. P. falciparum Hsp70-1 (PfHsp70-1; PF3D7_0818900) and P. falciparum Hsp90 (PfHsp90; PF3D7_0708400) are some of the major Hsps involved in the cytoprotection of the parasite and therefore pathogenesis of malaria. Hsp70 and Hsp90 are brought into close proximity by …
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Aufklärung des molekularen Mechanismus des Nukleotidaustausches von Hsp70-Chaperonen
… Klasse der 70 kDa Hitzeschock-Proteine (Hsp70) übernimmt mit ihren Co-Chaperonen wichtige Aufgaben bei der korrekten Faltung neu-synthetisierter Proteine. Darüber hinaus schützen die Hsp70s besonders unter Hitzestress die Zelle vor gefährlichem Verklumpen (Aggregation) missgefalteter …
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Evaluation of the immunomodulatory activity of Plasmodium falciparum hsp70-1
… prevail in the host environment. P. falciparum Hsp70-1 (PfHsp70-1) is a ubiquitous, cytosol-localised Hsp70 that is essential for parasite survival. Apart from their role as molecular chaperones, it is believed that some Hsps of parasitic origin are capable of modulating host immunity through …
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Hsp70-Mediated Regulation of Hsf1 Transcriptional Activity In Saccharomyces Cerevisiae
… of HSF1 involves the major heat shock proteins Hsp70 and Hsp90. Recent advances in the understanding of this regulatory circuit in <em>Saccharomyces cerevisiae</em> have shown that the Hsp70 Ssa1 acts as a sensor for some proteotoxic stresses and is capable of a direct interaction with Hsf1. …
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Identification of small molecule inhibitors targeting Plasmodium falciparum Hsp70-Hop pathway
… for survival. Heat shock protein 70 (Hsp70) together with heat shock protein 90 (Hsp90) are regarded as the most abundant cellular chaperones. Hsp70 and Hsp90 cooperate in order to exchange peptide substrates for folding and maturation. The cooperation of Hsp90 and Hsp70 is known to be …
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Functional Analysis of Cytosolic Hsp70 Nucleotide Exchange Factor Networks In Yeast
<p>The Hsp70 class of molecular chaperones play critical roles in protein homeostasis via an ATP-dependent folding cycle. Cytosolic Hsp70s in the budding yeast <em>Saccharomyces cerevisiae, </em>Ssa and Ssb, interact with up to three distinct nucleotide exchange factors (NEFs) homologous to human …
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Assessing the role of Hsp70 in prion propagation in Saccharomyces cerevisiae
… The heat shock proteins (HSP) such as Hsp40, Hsp70 and Hsp104, are essential for prion propagation in yeast. Hsp70 is a highly conserved protein composed of an N-terminal ATPase domain, a peptide-binding domain (PBD) and a C-terminal domain. In this study we describe a genetic screen that …
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HSP70 as a Target for Correction of Wilson Disease Causing ATP7B Mutants
… of WT and H1069Q variants of ATP7B, I found HSP70 as a specific mutant interactor that regulates ER retention and degradation of ATP7B-H1069Q. HSP70 suppression (with either RNAi or allosteric inhibitor) improved stability of the mutant and facilitated its export from the ER to the Golgi and …
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Expression von Hitzeschockprotein 70 (Hsp70) in den Atemwegen und Lungen von Brandtodesfällen
… exprimierten Zellmarkers "Hitzeschockprotein" (Hsp70) im Respirationstrakt bei Brandleichen nachzuweisen. Als Kontrollgruppe dienten 55 nicht selektierte Fälle aus Freiburg, die nicht mit einem Brandgeschehen in Zusammenhang gebracht werden konnten. <br>Es konnte eine statistisch signifikant …
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In cellulo and biophysical exploration of the role of GGMP residues of Hsp70
Hsp70 is a prominent molecular chaperone. Structurally, Hsp70 is composed of two domains, C-terminus substrate binding domain (SBD) and nucleotide binding domain (NBD). The NBD of Hsp70 is responsible for its ATPase activity. Some Hsp70s of parasites particularly those of apicomplexa are marked by …
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Biochemical Characterization of Binding Partners of Two Hsp70 Co-Chaperones In Saccharomyces Cerevisiae
… repair or removal of misfolded proteins.</p> <p>Hsp70, an evolutionarily conserved molecular chaperone, promotes protein folding and helps maintain them in a functional state. Requisite co-chaperones, including nucleotide exchange factors (NEFs) strictly regulate and serve to recruit Hsp70 to …
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Functional significance of Hsp70 post-translational modification in prion propagation and cellular function
… essential role for molecular chaperones, namely Hsp70 and Hsp104. The Hsp70 chaperone family and its associated co-chaperones are highly conserved from yeast to mammals. A major function of Hsp70 is to prevent the aggregation of denatured proteins by binding to exposed hydrophobic regions and …
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Investigating The Role of Prmt1 and Arginine Methylation of Hsp70 In Human Pancreatic Cancer
… of this study, several heat shock protein 70 (HSP70) family members were found to interact with PRMT1 in co-immunoprecipitation assays. Furthermore, using in vitro methylation assay and mass spectrometry analysis, I revealed that HSP70 was a novel methylation substrate of PRMT1, and conserved …
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Ueber die Beteiligung der Hitzeschockproteine HSP27 und HSP70 an einer Resistenz, Resistenzentwicklung unter CMF-Therapie
… in Mamma-Karzinomen stark exprimierte HSP27 und HSP70 scheinen hier beteiligt. Hitzeschockproteine sind Teil eines durch Noxen induzierten Mechanismus, welcher Schutz vor weiterer Noxenexposition verleiht, also die entsprechenen Zellen im Unterschied zu nicht exponierten Kontrollzellen zu …
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Redox Sensing By Yeast Hsp70 Facilitates Modulation of Protein Quality Control and The Cytoprotective Response
… (proteostasis) relies on the ubiquitous Hsp70 chaperone family. Hsp70 activity has been previously shown to be modulated by modification of two key cysteines in the ATPase domain by oxidizing or thiol-modifying compounds. To investigate the biological consequences of cysteine modification …
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Identification and partial characterisation of the HSP70 gene of the South African abalone Haliotis midae
… in understanding invertebrate immunity. The HSP70 gene from Haliotis midae was successfuly cloned and sequenced, and was found to have highest similarity (99%) with Haliotis diversicolor.
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