Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"heart function"”.
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SIRT1 ACTIVATION IMPROVES HEART FUNCTION THROUGH INHIBITION OF INFLAMMATION IN CHAGAS DISEASE
… 1 (SIRT1) would be beneficial in maintaining heart health in Chagas disease. We found that treatment with SIRT1 agonists, given in a therapeutic window of time after Trypanosoma cruzi infection, had no beneficial effects in reducing the cardiac remodeling and mitochondrial biogenic defects in …
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Effects of mutant SHP2 expression on heart function in Duchenne muscular dystrophy
… their forties. Consequently, the prevalence of heart disease has risen in DMD patients. Dilated cardiomyopathy typically develops during adolescence and progresses to heart failure. SH2 domain-containing tyrosine phosphatase 2 (SHP2) plays a regulatory role in several cell signaling events. Work …
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BUBR1 in Cardiac Biology: From Cardiogenesis to Adult Heart Function and Aging
Congenital heart defects and cardiac diseases associated with aging such as heart failure are leading contributors to morbidity and mortality worldwide, yet their underlying molecular mechanisms remain incompletely understood. This dissertation investigates the role of BubR1, a mitotic checkpoint …
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THE INFLUENCE OF EXERCISE BEFORE AND DURING PREGNANCY ON OFFSPRING HEART FUNCTION AND DEVELOPMENT
… benefits for fetal and infant development (e.g. heart health and development). Most studies examining the influence of exercise during pregnancy on infant outcomes have enrolled women that were previously active and the exercise during pregnancy was self-reported. Therefore, we do not know if …
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The effects of hypocapnia on cardiac electrical activity and heart function and its relevance to the diagnosis of coronary artery disease
… O\(_2\)), on cardiac electrical activity and heart function were investigated using an electrocardiogram (ECG) and echocardiogram. In addition, a pilot study was conducted to examine the effect of hypocapnia on the ECG of four patients suffering from coronary artery disease with stable angina. …
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Defining a role for the cystic fibrosis transmembrane conductance regulator in the heart
… fibrosis transmembrane conductance regulator) function affects numerous tissues and systems throughout the body. Concerning the heart, right ventricular dysfunction secondary to pulmonary abnormalities has long been recognized. However, the issue as to whether loss of CFTR function causes …
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Identification and Characterization of the Role of REEP5 in Sarco-Endoplasmic Reticulum Formation, Maintenance, and Function in Cardiac Muscle
Heart failure (HF) remains the most rapidly rising cardiovascular disease and the leading cause of inpatient hospitalization worldwide, with costs exceeding $30 billion dollars annually in North America. While many key regulators of heart function have been identified, yet effective therapies aimed …
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The role of early management and hormone replacement therapy in potential heart and lung donors
Heart and lung transplantation activity is frustrated by the lack of availability of donor organs. The haemodynamic, hormonal and inflammatory changes that follow brain stem death leads to donor organ injury. Appropriate donor management is essential to avoid further damage to already injured donor …
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Heartbeat rate modulation mediated by the ventral nerve cord in the honey bee, APIS MELLIFERA
… circulatory physiologists believe the insect heart to be myogenic. There is disagreement, however, about mechanisms regulating heart function. Modulation is considered to occur via either neural or neurohormonal mechanisms but there is little existing data of the type necessary for proving one …
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Mitochondrial protein acetylation and left ventricular function in a model of hypertrophic cardiomyopathy and heart failure
Rationale: The childhood heart disease of Friedreich’s Ataxia (FRDA) is characterized by hypertrophy and failure. It is caused by loss of frataxin (FXN), a mitochondrial protein involved in energy homeostasis. FRDA model hearts have increased mitochondrial protein acetylation and impaired sirtuin 3 …
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Testing metabolic and pharmacological agents for recovery following de novo acute heart failure in an isolated rat heart model
Acute heart failure is a potentially lethal clinical emergency without any effective therapy. Using an isolated rat heart model, we established and validated a model of de novo acute heart failure to study novel putative cardio protective therapies against acute heart failure, including glucose, …
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Risk Factors Associated With Pressure Injury in Pediatric Congenital Heart Disease Patients
<p>Pediatric congenital heart disease (CHD) patients have unique risk factors associated with the pathophysiology of abnormal heart function. This vulnerable population is likely at an increased risk of acquiring a pressure injury during hospitalization. There are limited studies that include …
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The Effects of Cocaine and Ecstasy on Cardiac Myocytes and the Intact Myocardium
… investigation pertains to their effects on the heart. The purpose of the current studies was to test the hypothesis that exposure to cocaine or ecstasy will adversely affect cellular homeostasis and normal heart function. Cultured cardiac myocytes (H9c2) and New Zealand White rabbits …
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Leveraging Right and Left Ventricular Coupling for Optimization of Mechanical Circulatory Support
… mechanical support risks decompensation if the heart and lung cannot tolerate these changes. One particularly concerning consequence of altered coupling is that upwards of 40% of patients with left-sided mechanical support face ensuing right heart failure, which requires urgent action and often …
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Microfuidic Devices and Open Access Tool for Localized Microinjection and Heart Monitoring of Drosophila Melanogaster
… of intact Drosophila larvae for recording heart activities upon injection of controlled dosages of different chemicals. In objective 2. we have developed software for in-vivo quantification of essential heartbeat parameters on intact Drosophila larvae. Several image segmentation and signal …
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A theoretical study of left ventricular and heart muscle dynamics
… of the left ventricle of the human heart considered as a pump have been extensively analysed. Using a new approach relying heavily on the Tensor Calculus, a theoretical model describing the mechanical and dynamical operation of the left ventricle has been developed. This has …
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ΜΕΛΕΤΗ ΤΗΣ ΕΠΙΔΡΑΣΗΣ ΤΟΥ PAF ΣΤΟ ΚΥΚΛΟΦΟΡΙΚΟ ΣΥΣΤΗΜΑ ΤΩΝ ΕΠΙΜΥΩΝ ΚΑΙ ΣΤΗ ΡΥΘΜΙΣΗ ΤΗΣ ΜΕΤΑΦΟΡΑΣ ΙΟΝΤΩΝ ΣΤΟ ΠΡΩΤΟΖΩΟ TETRAHYMENA PYRIFORMIS
… CA2+, NA+ AND K+ WHICH PLAYS A MAJOR ROLE ON THE HEART FUNCTION WERE STUDIED. FOR THE BETTER EXPLANATION OF THE AGEPC ACTION TWO DRUGS (VERAPAMIL AND DIGOXIN) WERE USED AS POSSIBLE INHIBITORS AND WHICH ARE OFTEN USED IN CARDIAC DISEASES. IN THIS STUDY THE CELL OF THE PROTOZOO TETRAHYMENA …
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Hydration and Water Distribution Studies of Heart Muscle by Nuclear Magnetic Relaxation
The multinuclear magnetic relaxation behavior of heart muscle from chicken, pork, and beef is investigated. Nonlinear regression analysis of the $\sp1$H transverse magnetization decay yields the best fit with three exponential components that are likely to correspond to three separate types of …
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Electrocardiogram signal processing and classification using neural network computing
… measurement of the electrical activity of the heart, and it is called the language of the heart, since from which the heart function and abnormality can be assessed, and this analysis process can be greatly assisted by current computer technology. In this thesis, artificial neural networks are …
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Functional Effects of Calcium Regulation of Thin Filaments at Single Particle Resolution
<p>Heart disease is the leading cause of death in the United States. Understanding heart function at the molecular level is critical for developing of more effective treatments. In the cardiac muscle, the thin filament is composed by troponin (Tn), tropomyosin (Tm), and F-actin. It provides …
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