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Showing 1 to 20 of 304 for “"haplotype"”.
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Haplotype block and genetic association
… genome has attracted much attention since each haplotype block contains limited sequence variation, which can reduce the complexity in genetic mapping studies. This dissertation focuses on estimating haplotype block structures and their application to genetic mapping using single nucleotide …
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Haplotype Inference through Sequential Monte Carlo
… arguments have been made for the use of haplotypes, i.e. combinations of alleles at multiple loci in individual chromosomes, as opposed to genotypes so the problem of haplotype inference is particularly relevant. Existing haplotyping methods include population based methods, methods for …
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Shared Haplotype Length Regression and Its Application
… of a novel statistical approach based on haplotype sharing concepts. The approach is motivated by the fact that a new variant in a population arising via mutation or migration will reside on a unique haplotype. Assuming the new allele does not become extinct, recombination events at each …
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Algorithms For Haplotype Inference And Block Partitioning
… of SNPs on a block of the chromosome is called a haplotype. Each block might contain a large number of SNPs, but a small subset of these SNPs are sufficient to uniquely dentify each haplotype in the block. The haplotype map or HapMap is a map of these haplotype blocks. Haplotypes, rather than …
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Haplotype-Based Association Studies: Approaches to Current Challenges
<p>Haplotype-based association studies have greatly aided researchers in their attempts to map genes. However, current designs of haplotype-based association studies lead to several challenges from a statistical perspective. To reduce the number of variants, some researchers have employed …
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Haplotype-Informed Allelic Imbalance Detection From Rna In Cancer
… approach that overcomes these challenges using haplotype information to aid detection of somatic chromosomal copy number alterations (SCNAs), which result in allelic imbalance, i.e., deviations from the expected 1-to-1 allelic ratios at heterozygous loci. We initially applied a native version of …
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Haplotype-Based Approaches For The Study Of Human Evolution
… these two projects together is a reliance on haplotype-based methods, which leverage patterns of linkage across genetic variants, to better understand the evolutionary forces at play across the genome. The first chapter addresses the question, how often are signatures of recent positive …
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Linkage disequilibrium and haplotype block patterns in popcorn populations
Linkage disequilibrium (LD) and haplotype blocks have been a preliminary and powerful knowledge for genomic investigates in humans, animals and plants. We aimed to describe the LD measures, D’ and r 2 , and to characterize haplotype block patterns in popcorn populations (synthetic and breeding …
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An HMM-based boundary-flexible model of human haplotype variation
… of a meaningful and detailed description of haplotype variation holds the promise for more powerful genetic association studies. The segmentation of the human genome into blocks of limited haplotype diversity has been successfully employed by models that describe common variation. Some …
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Linkage disequilibrium and haplotype block structure in six commercial pig lines
O sucesso de estudos de associação e, consequentemente, a seleção genômica dependem da densidade de marcadores utilizados nas análises, a qual, por sua vez, é determinada pela extensão do desequilíbrio de ligação (LD) ao longo do genoma. O LD é organizado em blocos de haplótipos, separados por hot …
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Computational Methods for Haplotype-aware De Novo Genome Assembly from Long Reads
… each genome copy and strain (together are called haplotype here), which is referred to as haplotype-aware genome assembly, plays a crucial role in genomics, medicine, and many other disciplines, because biological functionalities or phenotypic appearance can differ substantially across different …
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Forensic identification of six of Tanzanian populations using the extended haplotype markers
… studies. Eleven Y chromosome extended haplotype markers were selected for this study, these includes Minimal haplotypes markers i.e. DYS19, DYS390, DYS391, DYS392, DYS393, DYS385a/b, DYS389I/II and two additional markers DYS438 and DYS439. Six populations of Tanzania were investigated …
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Haplotype-Specific Effects of the Slam/Cd2 Family on the Immune Response
… of the Slam/CD2 family revealed two stable haplotypes in a panel of 33 common inbred strains of mice. The first haplotype is only found in B6 and other C57- related strains. The more common second haplotype is found in Sle1b and other autoimmune strains such as MRL, NOD, and NZB, as well as …
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Mitochondrial Haplotype Influences the Impact of Simulated Climate Warming on a Tropical Ectotherm
… a significant interaction between mitochondrial haplotype and temperature treatment, thus demonstrating genotypedependent effects and the potential for an adaptive evolutionary response to climate warming.
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Investigation into X-STR haplotype frequencies for forensic human identification in South Africa
… using StatsX and Arlequin. Herein, allele and haplotype frequencies and forensic parameters for the South African population are reported, as well as data related to the reproducibility, sensitivity, limit of detection, and concordance of the Investigator Argus X-12 QS kit. DXS10135 was the …
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AlphaFold2 reveals structural patterns of seasonal haplotype diversification in SARS-CoV-2 structural protein variants
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-09-16 without embargo terms
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DNA Sequence and Haplotype Variation Analysis of Inflammatory Response Genes NLRX1, IL6, and IL8 in the Turkey (Meleagris gallopavo)
Genotype-phenotype analyses continue to be the primary goal for genome analyses in livestock and poultry breeding. Essential to accomplish this goal is the need to identify variation at the genomic level. To test the hypothesis that DNA sequence variations in inflammatory response genes are …
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DNA Sequence and Haplotype Variation Analyses of Circadian Clock Genes and Their Effects on Phenotypes in the Turkey, Meleagris gallopavo
… DNA sequence variations at the nucleotide and haplotype levels are associated with some of growth, reproductive parameters and plasma melatonin of turkeys. Thus DNA sequence variations that identified of the circadian genes may have some regulatory role in the molecular mechanism of the …
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Application of High Resolution Melting analysis for haplotype detection in phylogeographic research and case studies of Arenaria ciliata, A. norvegica and Minuartia recurva (Caryophyllaceae)
… on real-time PCR is introduced as a tool for haplotype detection in phylogeographic research. Second, phylogeographic study of three arctic-alpine or alpine plant species in the family Caryophyllaceae is carried out based on the haplotype data obtained through established protocol of HRM …
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