Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"granuloma"”.
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A zebrafish model to study the schistosome egg granuloma
… produce, and is primarily characterized by the granulomas which form around them. While the granulomas have pathological consequences to the host, they are thought to be essential to facilitate egg expulsion and completion of the parasite life cycle. Here, I have developed a larval zebrafish …
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Effect of Lactoferrin to Increase Drug Permeability of Primary Pulmonary Mycobacterial Granulomas
… The host-pathogen interaction, pulmonary granuloma formation, and <em>Mtb</em> adaptions result in increased complexity of the disease. Granulomas are formed by active immune responses generated during <em>Mtb</em> infection, and serve to contain and limit bacterial dissemination. The …
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The role of IL-4 and IL-13 responsiveness during Schistosoma mansoni induced inflammation
… due to poor egg excretion and dysregulated granuloma formation. This resulted in increased mortality. To determine the role of AAMФ in granuloma we aimed to describe S.mansoni egg induced granuloma formation in the presence and absence of AAMФ using LysMcreIL-4Rα-/lox mice.
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Cell Wall Lipids Promoting Host Angiogenesis During Mycobacterial Infection
… of characteristic immune cell aggregates called granulomas. In humans and animal models, tuberculous granuloma formation is accompanied by dramatic remodeling of host vasculature which ultimately benefits the infecting mycobacteria, suggesting the bacteria may actively drive this host process. …
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HP Turns 17: T helper 17 cell response during hypersensitivity pneumonitis (HP) and factors controlling it
… antigens. It is characterized by alveolitis, granuloma formation, and fibrosis. Since HP is a T cell-mediated disease, it is important to determine the type of T cell response associated with granuloma formation and the factors that control this response. We hypothesized that HP is associated …
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Pathogenesis of experimental tuberculosis in guinea pigs
… tissues and organs of the body. Granulomatous inflammation can become organized into a distinct inflammatory mass referred to as a granuloma. Granuloma formation is thought to represent a favorable host response that functions to contain the infection, thus preventing spread …
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Το ηωσινόφιλο κοκκίωμα των οστών: από ορθοπεδική άποψη
THIRTY FIVE CASES OF EOSINOPHILIC GRANULOMA OF BONE WHICH WERE TREATED IN THE ORTHOPAEDIC CLINICS OF ASCLIPIION HOSPITAL DURING THE LAST 20 YEARS, HISTOLOGICALLY CONFIRMED, WERE REVIEWED. THE RARITY OF THE DISEASE WAS CONFIRMED BECAUSE ITS FREQUENCY WAS FOUND ONLY 1% IN RELATION TO THE OTHER …
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Characterizing Host Protective Immune Responses to the Parasitic Worm Heligmosomoides polygyrus
… H. polygyrus larvae induce an intestinal granuloma response whereby immune cells, mostly alternatively activated macrophages and eosinophils, accumulate around the tissue encysted parasites. In vitro, these cells and antibodies immobilize, damage/kill worms within the granuloma. This is …
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Hybrid modeling techniques to support drug-development and post-market analysis of anti-infectives
… first case-study regards the support of a novel granuloma-centric approach to anti-tuberculosis (TB) regimen design through the quantification of site-of-action pharmacokinetic attainments of any anti-TB compound to come. In a step-wise manner, an in vivo minimal physiologically-based …
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Protein Kinase D1 in Myeloid Cells Promotes Disease Progression and Severity in S. rectivirgula Induced Hypersensitivity Pneumonitis
… and alveoli of the lung that leads to granuloma formation. Myeloid lineage immune cells play a critical role in the early and late stages of the disease, and this activity is mediated through toll-like receptors (TLRs) expressed by these cells. Protein kinase D1 (PKD1) has previously …
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Immune Modulation of The Mycobacterium Tuberculosis Granulomatous Response
… (MTB) infection by the formation of granulomas, which initially prevent uncontrolled bacterial proliferation and dissemination. However, increasing evidence suggests that granuloma formation promotes persistence of the organism by physically separating infected cells from effector …
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Pharmacologic investigation of the anti-inflammatory activity of cryogenine and selected benzoquinolizine derivatives
… pedal edema) and proliferative (cotton pellet granuloma) models of inflammation when administered orally.
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Pathology of parasitic infections in marine teleosts
… of the lesion which was Interpreted as a granuloma. Eggs released by this progenetic metacercaria did not produce separate granulomata.
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The role of endotoxin receptors toll-like receptor 4 and lipopolysaccharide-binding protein in Mycobacterium tuberculosis infection
… inflammatory processes and in the development of granuloma? What role do the PRRs play in driving cytokine and chemokine response? Specifically, the following mice were infected aerogenically with Mtb H37Rv to further investigate their roles in vivo in mounting an effective immune response: …
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Hematologic effects of cryogenine and certain selected anti-inflammatory agents
… adjuvant-induced arthritis and cotton pellet granuloma formation) during drug evaluation. The parameters under investigation included: total white blood cell count, differential leukocyte count, sedimentation rate and serum protein patterns.</p>
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Anti-platelet aggregation activity of melaleuca bracteata var.revolution gold derived betulinic acid and its derivatives
… was investigated using the cotton pellet-induced granuloma model in rats. The homogenates from the granuloma tissues were used to determine the effect of the test compounds on catalase (CAT) and superoxide dismutase (SOD) activities. The in vitro effect of the triterpenes on cyclooxygenase COX-1 …
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Physiologically-Based Pharmacokinetic (PBPK) Modeling for the Preclinical Development of Spectinamide Antibiotics
… lesions, we also utilized the established Simcyp granuloma model to explore the distribution of spectinamide 1599 within granuloma substructures. Simulation results suggest substantial exposure in all lesion substructures, with particularly high exposure in the rim region and in macrophages of the …
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Reactivation of persistant tuberculosis
… system and survive in a dormant state within granuloma. lmmunosuppression, however, may result in reactivation of active tuberculosis resulting in clinical disease. Using low dose aerosol infection of M. tuberculosis in mice, a short-duration model of rifampicin-isoniazid (RMP-INH)-induced …
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Immunologic and Protective Effects of Vaccines for Mycobacterium marinum in Morone sp
… reduced splenic bacterial counts, and reduced granuloma formation compared to the control groups. However, though the vaccination groups did not demonstrate the same acute effects post-challenge as the control groups, the vaccination groups ultimately developed increased splenic bacterial …
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Zebrafish Mutagenesis Study of Host Determinants of Mycobacterial Infection Outcome
… show accelerated macrophage death resulting in granuloma failure. Pharmacological inhibition of cell death pathways associated with mycobacterial infection did not influence uxt mutant susceptibility to infection, suggesting that uxt deficiency results in a novel form of death in …
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