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Showing 1 to 13 of 13 for “"glutaredoxin"”.
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Characterization of the Role of Glutaredoxin 3 and Its Binding Partners In Maintaining Iron Homeostasis In Saccharomyces Cerevisiae
… pathway that includes the cytosolic monothiol glutaredoxins, Grx3 and Grx4. The crystal structure of the thioredoxin-like domain of Grx3 has been determined at 1.5 ├â┬à resolution and represents the first published structure of this domain for the monothiol glutaredoxin family. To characterize …
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Adventitious disulfide bond formation in Escherichia coli and the involvement of thioredoxin and glutaredoxin in suppressing oxidative stress
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-12-01
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Novel strategies to increase Sirtuin-1 activity in aortic aneurysm
… cysteines on SirT1 (3M SirT1) or overexpressing glutaredoxin-1 (Glrx), an enzyme that prevents oxidative modifications on SirT1, was able to restore SirT1 activity in liver cells. OBJECTIVES: The goal of this study is to enhance SirT1 activity in aortas and VSM cells in a mouse model of AA …
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KINETIC, THERMODYNAMIC AND MECHANISTIC FEATURES OF ESCHERICHIA COLI BCP, AN UNUSUALLY VERSATILE PEROXIREDOXIN
… including Trx1, thioredoxin 2 (Trx2), glutaredoxin 1 (Grx1) and glutaredoxin 3 (Grx3). <italic>Ec</italic>BCP exhibited an unexpectedly high redox potential of – 145.9 ± 3.2 mV, the highest recorded value for a Prx. The unusually high redox potential increases the …
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Novel Molecules that Regulate Bone Formation and Bone Resorption
… In my dissertation, we investigated the role of Glutaredoxin 5 (Grx5), Diabetes and Obesity Related protein (DOR), and Claudin 18 (Cldn-18), novel molecules involved in regulating bone formation and bone resorption. We demonstrated that Grx5 protects osteoblasts from oxidative stress induced …
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IDENTIFICATIN AND CHARACTERIZATION OF PATHOGENICITY GENES IN FUSARIUM VIRGULIFORME, THE CAUSAL AGENET OF SUDDEN DEATH SYNDROME (SDS) IN SOYBEAN
… identification and characterization of dithiol glutaredoxin gene in <italic>F. virguliforme</italic> . The role of FvGRX2 in the fungal defense to phytoalexin, glyceollin and induced oxidative burst was also investigated by generating an<italic>FvΔgrx2</italic> knockout. In order to establish a …
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Isolation and Characterization of Proteins Interacting with Tobacco Transcription Factor TGA2.2
… in der Hefe mit At1g28480 Protein, ein Glutaredoxin, das bekannt, um Disulfid-Brücke zwischen Proteine zu katalysieren. At1g50570 interagiert mit alle TGA- Faktoren aus Tabak. Die Interaktion zwischen At1g28480 und TGA2.2 wurde weder durch oxydierende Stresszustände beinflusst, noch …
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Characterizing Factors That Influence Intracellular Thiol-Disulfide Equilibrium
… the role that the oxidoreductase human glutaredoxin 1(hGrx1) plays in reduction of the critical disulfide bond in human superoxide dismutase 1 (hSOD1). hSOD1 is normally a protective enzyme that detoxifies superoxide (O2*). However, mutations in hSOD1 can cause amyotrophic lateral …
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Arabidopsis thaliana class II TGA transcription factors provide a molecular link between salicylic acid and ethylene defense signalling
… und deren Interaktionspartner, die CC-Typ Glutaredoxine, als entscheidendes regulatorisches Modul im antagonistischen Zusammenspiel des SA- und JA-Signalweges auf den JA/ET-Signalweg identifiziert. In Kapitel II werden die Klasse II TGA-Transkriptionsfaktoren, die bisher nur bekannt als …
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Large-scale studies and biophysical analysis of systems involved in plant immunity.
… that clade I TGA recruits a specific novel glutaredoxin as a corepressor to dampen the expression of a set of SAR-regulated genes controlled by salicylic acid (SA) and the SAR-orchestrator, NPR1. Finally, we demonstrated that NPR1 binds SA and that this interaction leads to the …
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Homoglutathione Synthetase And The Plant Thiol-Redox Proteome
… redox-couples and reversible, thioredoxin- or glutaredoxin-mediated protein disulfides. This work examines first the structural basis for synthesis of these small molecules and second how plants are able to adapt and respond to changes in environmental redox state. Among the major …
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Functional stability of plant peroxiredoxins
… and PrxII C in presence of thiredoxin (Trx) and glutaredoxin (Grx). In vitro, Trx enabled higher activity of PrxII B than of PrxII C, whereas Grx-dependent peroxidase function was more enhanced with PrxII C. The cytosolic Grx CxxC4 allowed for the regeneration of both Prxs but not the cytosolic …
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D-METHIONINE (D-MET) MECHANISMS UNDERLYING OTOPROTECTION FROM NOISE- AND AMINOGLYCOSIDE-INDUCED HEARING LOSS
… collected for endogenous antioxidant analysis. Glutaredoxin 2 (Grx2) was also analyzed 21 days post-noise exposure. Lower D-met doses (25 and 50 mg/kg/dose) increased superoxide dismutase and catalase activity. Glutathione reductase and glutathione peroxidase activities significantly increased …