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Showing 1 to 20 of 88 for “"gluconeogenesis"”.
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An In silico Liver: Model of gluconeogenesis
… to represent the complex interplay between gluconeogenesis, lipid metabolism, and alcohol metabolism in the fasted rat liver. Biochemical pathways are represented by key kinetic reactions that include allosteric and substrates effectors, and phosphorylation/dephosphorylation enzymes …
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Control of Gluconeogenesis in Biotin-Deficient Rats
Made available in DSpace on 2015-05-12T22:36:27Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 7219786.PDF: 5521611 bytes, checksum: d109163986b52797bd3a0f2da3be7e1b (MD5) Previous issue date: 1972
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Cellular Studies of Gluconeogenesis in the Ruminant
Made available in DSpace on 2014-12-14T15:29:38Z (GMT). No. of bitstreams: 1 7524401.pdf: 3931235 bytes, checksum: 3cc3c11eb5c2e21d2ad71b9cbbbe6ecb (MD5) Previous issue date: 1975
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The role of salt-inducible kinase in the control of hepatic gluconeogenesis
Regulation of hepatic gluconeogenesis by hormones insulin and glucagon is central to glucose homeostasis. Recent work has proposed that amongst the salt inducible kinase isoforms (SIK1, 2 and 3), members of the AMPK-related kinase family, the SIK2 isoform may play a role as signalling mediator in …
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Influence of Homeorhetic State on Ruminant Metabolism and Substrate Selection for Hepatic Gluconeogenesis
… that the contribution of amino acids to hepatic gluconeogenesis would increase when glucose demand was increased in ruminants. Our first approach was to establish a sheep model for increased glucose demand. Four wethers injected with excipient or.5, 1.0, or 2.0 g/d of phlorizin excreted an …
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A New Technique for the Isolation of Chicken Hepatocytes and Their Use in Investigations on Gluconeogenesis
Made available in DSpace on 2014-12-13T19:42:50Z (GMT). No. of bitstreams: 1 8004272.pdf: 3837185 bytes, checksum: e86b1631839b3acf28b11e1060f23f9a (MD5) Previous issue date: 1979
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Propionate induces gluconeogenesis in dairy cattle through direct activation of the bovine cytosolic phosphoenolpyruvate carboxykinase gene promoter
… (PEP), a critical reaction for gluconeogenesis. The two isoforms of PCK, namely cytosolic PCK (PCK1), and the mitochondrial PCK (PCK2) are abundantly expressed in liver and kidney. Increased PCK1 activity and mRNA expression in liver is observed as feed intake recovers during …
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Endogenous glucose production and gluconeogenesis during exercise in athletes on either a low-carbohydrate or mixed diet
… source of this glucose is via the process of gluconeogenesis (GNG). However, endogenous glucose production (EGP) and GNG has not been studied during exercise in athletes on a LCHF diet. Therefore, the aim of this study was to determine if there are differences in EGP, GNG and glycogenolysis …
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Gluconeogenesis as a system : development of in vivo flux analysis of hepatic glucose production in Type 2 Diabetes
… glucose production in the liver. Hepatic gluconeogenesis provides de novo formation of glucose from three carbon precursors such as glycerol, lactate, pyruvate and alanine. The upregulation of this pathway underlies the persistent hyperglycemia observed in diabetic patients. We have …
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Gluconeogenesis in the liver of growing and lactating ruminants: the influence of ration composition and stage of lactation
… are important factors in ruminant metabolism.. Gluconeogenesis, a pathway especially important in ruminants, is affected by both factors. In calves and cows, concentrate rations increased glucose production. Ration RDN, studied in calves, affected lactate metabolism to glucose. The liver of …
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ER Stress is Linked to the Regulation of Hepatic Gluconeogenesis and Phosphatidylinositol 3-kinase/Akt Signaling Post Burn Injury
Burn injury is a severe form of trauma that causes changes in glucose metabolism. Glucose metabolism is controlled during early burn injury but later results in stress induced diabetes. We have shown that this is due to differential regulation of the insulin signaling pathway in the liver.
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Preliminary investigations for studying the effects of low carbohydrate high fat diets on gluconeogenesis in type 2 diabetes patients
… is the dysregulation of glucose production via gluconeogenesis, which is a key pathology of T2D but which has been incompletely studied. Indeed, the effects of LCHF eating on gluconeogenesis in T2D patients has not yet been studied, nor has gluconeogenesis been investigated in the context of T2D …
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Effects of Reduced Phenolic Acids on Ruminant Hepatic Metabolism
… All the reduced phenolics inhibited gluconeogenesis from propionate in bovine liver tissue at.4 mM and BA, PPA, and CA inhibited it at.2 mM. Oxidation of palmitate was inhibited by all the reduced phenolics (.2 mM) with 4OHPPA being least inhibitory. The reduced phenolics caused …
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Non-Canonical Roles of Cytosolic Phosphoenolpyruvate Carboxykinase in Small Intestine Metabolism
… to be the quintessential regulatory enzyme of gluconeogenesis. This common perspective of PEPCK solely functioning in gluconeogenesis is too narrow and does not do justice to the complexity and number of pathways in which this enzyme participates. PEPCK performs important roles in a number of …
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ΕΠΙΔΡΑΣΙΣ L-ΘΡΥΠΤΟΦΑΝΗΣ ΕΠΙ ΕΝΖΥΜΩΝ ΤΟΥ ΜΕΤΑΒΟΛΙΣΜΟΥ ΤΗΣ ΑΛΑΝΙΝΗΣ, ΓΛΟΥΤΑΜΙΝΙΚΟΥ ΚΑΙ ΑΣΠΑΡΤΙΚΟΥ ΗΠΑΤΟΣ ΕΠΙΜΥΟΣ
… OF GPT. 5) L- THRYPTOPHANE INHIBITS LIVER GLUCONEOGENESIS BY THE INHIBITIONIN THE SPECIFIC ACTIVITIES OF GPT AND GOT. 6) GLUCONEOGENESIS AND GPT GOT (EXTRAMITOCHONDRIAL) ARE RELATED.
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Dietary Protein Regulation of Insulin Sensitivity and Glucose Homeostasis
… disposal of dietary CHO and upregulating hepatic gluconeogenesis under fasted conditions.
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Investigation of chicken embryo metabolism and substrate utilization during later development
… to 32 wk-old hens. Study Three aimed to quantify gluconeogenesis, and substrate utilization and partition in e14 and e19 embryos. A constant infusion protocol (8 h) was developed for delivery of [U-<super>13</super>C] glucose and [U-<super>13</super>C] glycerol into the chorio-allantoic fluid. …
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Defective branched chain amino acid catabolism impairs exercise capacity and glucose homeostasis in the mouse
… exercise, and the impact of elevated BCAAs on gluconeogenesis during exhaustive exercise. We found that defective BCAA catabolism significantly decreased endurance exercise capacity in the mouse, and this impairment may be due to disruption of glucose homeostasis. Although elevated BCAAs did …
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The role of pyruvate dehydrogenase kinase in glucose and ketone body metabolism
… that hypoglycemia was due to a reduced rate of gluconeogenesis. We hypothesized that hyperglycemia would be prevented in DKO mice fed a high saturated fat diet for 30 weeks. As expected, DKO mice fed a high fat diet had improved glucose tolerance, decreased adiposity, and were euglycemic due to …
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