Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"gene mapping"”.
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Gene Mapping of Morphological Traits in Chickens
… a source of experimental material to study the genetics of morphological traits. An important first step in such studies is to map the genes and the causal mutations that influence these traits. This research focused on gene mapping of 12 morphological traits including 4 intra-feather color …
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Power Analysis and Extension of a Robust Test of Linkage and Association of Human Complex Disease Genes
… main focus of this work is a modern approach for gene mapping of complex human diseases, the Transmission/Disequilibrium Test (TDT). My studies demonstrate that the TDT is a robust, nuclear family based analysis that can test linkage in the presence of association. I show the advantages and …
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The LASSO linear mixed model for mapping quantitative trait loci
… was one of the traits measured in the Davies' Gene Mapping Project. These data form the motivation for the methods presented in this thesis. Multiple QTL models have been previously proposed and are likely to be superior to single QTL models. The multiple QTL models can be loosely divided into …
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Single molecule analysis of DNA electrophoresis in microdevices
… electrophoresis technology is inadequate for mapping large O[100 kilobasepair] DNA, several promising lab-on-chip designs for DNA mapping have been recently proposed that require either 1) a DNA molecule negotiating an obstacle course in a microchannel or 2) stretching a DNA molecule for …
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Simulating DNA behavior in microfluidic devices
… size of these devices. One such application is gene mapping, which extracts, at a. coarse level, the information embedded in the base pair sequence of genomic DNA. This technology relies on the ability to manipulate single DNA molecules in order to perform such tasks as separating DNA based on …
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CMOS nanofluidics
… mentioned above, clinical applications, such as gene mapping for virus identification and protein separation for cancer diagnosis and monitoring, could potentially run on a chip without external equipment.
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Molecular characterization of three mental illness susceptibility genes
… notably the presence of psychosis. Overlapping genetic factors are involved in their pathogenesis and recently, genome-wide linkage scans and association studies have identified many new genes. However, studies focusing on functional follow-up for these genes are very rare, leaving a big gap in …
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The Genetic Architecture of Alopecia Areata
… dearth of information about the underlying pathogenesis. In AA, autoimmunity arises against the hair follicles in the skin, which causes hair loss associated with an aberrant accumulation of immune-response cells around the affected hair follicles. Evidence supporting a genetic basis for AA stems …
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Regiões genómicas associadas à variação da coloração da pelagem em bovinos da raça GIR
… was to perform a GWAS to identify candidate genes for the coat phenotype and perform fine mapping of the MC1R gene, a gene that has already been reported to affect the coat in other cattle breeds. A total of 574 Gir animals were genotyped with a commercial Zoetis low-density chip of 29,842 …
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Haplotype-Based Association Studies: Approaches to Current Challenges
… aided researchers in their attempts to map genes. However, current designs of haplotype-based association studies lead to several challenges from a statistical perspective. To reduce the number of variants, some researchers have employed hierarchical clustering. This thesis starts by …
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Physical and genetical investigation of the Xp11.3 region on the short arm of the human X-chromosome
… inactivation status of the DXS8237E and PCTKl gene differ: the first undergoes normal inactivation and the second escapes this process. The status of the UBEl gene has been controversial, although it is widely excepted that it does escape X chromosome inactivation. Physical mapping of the …
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Mapping quantitative trait loci using multiple linked markers via Residual Maximum Likelihood
Mapping quantitative trait loci in outbred populations is important since development of inbred lines in livestock species is usually not feasible. Traditional genetic mapping methods, such as Least Squares and Maximum Likelihood, cannot fully accommodate complex pedigree structures, and more …
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Subclinical Phenotypes and Genotypes in Parents of Children with Non-Syndromic Cleft of Lip and/or Palate
… risk estimation and provide more informative and genetically homogenous groups for gene mapping.<b><br/></b><b><br/></b><b>Aim</b>: To assess facial morphology, the prevalence of upper lip sub-epithelial orbicularis oris (MOO) defects and lower lip whorls, and to determine tooth size and arch …
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Investigation of Putative Genetic Factors Associated with Soybean [Glycine Max (L.) Merr.] Seed Quality Traits
… requires a thorough understanding of the genetic factors that affect the manifestation of value added traits. Value added traits investigated in this study include seed sucrose, raffinose, stachyose, and phytate content, seed weight, and maturity. The objective of the first part of this …
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Understanding the Genetic Basis of Obesity: Lessons from Man’s Best Friend
… between environmental, behavioural, and genetic factors. Study of human obesity has been extensive whilst that in dogs has been limited. Past data on how biological risk factors impact canine obesity have been contradictory and the genetic basis of canine obesity is poorly understood. The …
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Profound childhood deafness in South Africa : a clinical and molecular genetic approach
… is hereditary in origin. In order to elucidate genetic factors in profound childhood deafness in South Africa, a diagnostic screening survey of 1060 hearing impaired children attending five special schools for the deaf was performed and the aetiology of hearing impairment in each child was …
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MUTACIN IV PRODUCTION IN STREPTOCOCCUS MUTANS UA159: CHARACTERIZATION, REGULATION, AND MECHANISM OF SELF-IMMUNITY
… and NlmB peptides to mutacin IV activity. Using genetic and biochemical approaches, we showed that the presence of both genes is required for optimum mutacin IV activity. We also showed that mutacin IV is active against multiple Streptococcus species. Our studies revealed that mutacin IV has …
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Identification, Validation, and Mapping of Phytophthora sojae and Soybean Mosaic Virus Resistance Genes in Soybean
… with core effectors to identify resistance genes (R-genes) that will be durable under field conditions. Four segregating populations and two recombinant inbred line (RIL) populations have been screened with core effectors. Effector-based screening methods were combined with pathogen-based …
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Generation of a human gene index and its application to disease candidacy
With easy access to technology to generate expressed sequence tags (ESTs), several groups have sequenced from thousands to several thousands of ESTs. These ESTs benefit from consolidation and organization to deliver significant biological value. A number of EST projects are underway to extract …
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Erstellung einer humanen und murinen physikalischen Genkarte zur Eingrenzung des Gen-Lokus für adoleszente Nephronophthise (NPH3), Identifizierung von Kandidatengenen und Mutationsanalyse des Kandidatengens KIAA0678
… terminalen Nierenversagen führt. Die kritische genetische Region konnte auf Chromosom 3q21-q22 identifiziert werden und weist Syntenie mit dem Lokus der murinen zystischen Nierenerkrankung pcy auf Maus-Chromosom 9 auf. Zum Nephronophthise-Erkrankungskomplex gehören auch Syndrome mit extrarenaler …
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