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Showing 1 to 20 of 32 for “"galectin-3"”.
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Functional properties of galectin-3. Beyond the sugar binding.
… activity of different macrophages. Proteins from galectin family were found to contribute to disease pathophysiology. Therefore, there is an intensive interest in understanding different galectin functions. The aim of this thesis was to pin-point specific galectin-3 roles in differently activated …
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Galectin-3 Enhances The Malignant Melanoma Phenotype By Regulating Autotaxin
… specimens and cell lines, the over expression of galectin-3 is associated with disease progression and metastatic potential. Herein, we have sought out to determine whether galectin-3 affects the malignant melanoma phenotype by regulating downstream target genes. To that end, galectin-3 was stably …
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Investigation of conventional and unconventional protein secretion using galectin-3
… surrounding the regulation of protein secretion. Galectin-3, an unconventionally secreted protein, was used here to investigate both conventional and unconventional protein secretion. The unconventional protein secretion of galectin-3 is poorly understood. To address this, genetic manipulation of …
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The role of Galectin-3 in the pathogenesis of Parkinson's Disease
… Recientemente se ha relacionado a la proteína Galectina-3 (Gal3) con los Cuerpos de Lewy en cerebros post-mortem. Gal3 es una proteína de unión a galactósidos sin actividad catalítica y expresada principalmente por células de la microglía, las células inmunes del sistema nervioso central, en …
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The Role of Galectin-3 in Pathogen Sensing and Cell Autonomous Defense
… leaflet of the membrane to the host cytosol. Galectins, cytosolic host glycan binding proteins, are then able to recognize the exposed sugars and bind them. Subsequently, host defense proteins including the guanylate binding proteins (GBPs) are recruited to the damaged membrane. I propose that …
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The role of galectin-3 and galectin-9 in the chronic inflammation of rheumatoid arthritis
… of a family of immunomodulatory proteins (galectins) in fibroblasts from rhematoid arthritis patients. Synovial fibroblasts were found to differ significantly from bone marrow and skin fibroblasts with higher expression of galectin-9 and galectin-12 in synovial fibroblasts. Galectin-9 and …
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Mechanistic Study of The Small Molecule Inhibitor DX-52-1
… with nanomolar concentration. We have identified galectin-3, a multifunctional protein whose best-known function is its sugar binding ability, as a secondary target of DX-52-1 with functions in cell motility. In addition, we have identified HUK-921, another small molecule with antimigratory …
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Identification of differentially expressed genes in breast cancer tissues and cells
… in nude mice; obtained by stable transfection of galectin-3 gene in a non-tumorigenic BT 549 breast cell line, was analyzed by differential display. Galectin-3, a calcium independent carbohydrate binding protein has been shown to be involved in many biological processes, but its exact function is …
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Studies on the Damage Associated Molecular Patterns (DAMPs)-induced Inflammatory Events in the Brain Immune Cells
… immune system. The second part, I showed that galectin-3 exerts cytokine-like regulatory actions in rat and mouse brain-resident immune cells. Expression and secretion of galectin-3 were significantly enhanced in glia under IFN--stimulated, inflamed conditions. After exposure to galectin-3, …
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The design and synthesis of fluorescent peptides and disaccharides for tumour imaging.
… probes. Chapter 2: β-Galactoside targeting of galectin-3 Galectins are a family of intra and extra-cellular proteins which bind specifically to the β-galactoside carbohydrate residues of cellular glycoproteins. Several galectins, but most significantly galectin-3, have been found to mediate …
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Structural analysis of cytokine signaling modulators
… modulate signal transduction by interacting with galectin-3 and generating a cell surface lattice. This opposes constitutive endocytosis and reduces the thresholds for cytokine signaling. The preferred ligands for galectin-3 are the poly-N-acetyl lactosaminylated tetra-antennary glycans which are …
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Microglial Phagocytosis of Bacteria and Synapses
… In this work, involvement of calreticulin, galectin-3, apolipoprotein E and β-amyloid in microglial phagocytosis of bacteria were studied. Microglia activated with bacterial endotoxin upregulated and released extracellular calreticulin and galectin-3 in culture, and both proteins could bind …
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Galectin binding proteins in serum and bronchoalveolar lavage -in healthy and pathological conditions
Galectins are carbohydrate binding proteins, implicated in conditions of both inflammation and cancer. Connections between chronic inflammation and cancer are proposed by the increased remodelling and proliferation that occurs, leading to enhanced survival and proliferation of malignant cells. …
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Engineered approaches to querying the microenvironment of cancer metastasis
… of ECM composed of fibronectin with any of galectin-3, galectin-8, or laminin. In the next part of this thesis, these molecules are investigated for their involvement in mice bearing the autochthonous tumors or in humans with lung cancer. The integrin Q3p1 is found to mediate adhesion to the …
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Characteristics and outcomes of acute heart failure in sub Saharan Africa
… relationship between plasma levels of BNP and galectin 3 and outcomes (cardiovascular (CV) death or HF hospitalization through week 24) as well as the relationship between the plasma levels of BNP and Gal3 and both left ventricular (LV) and right ventricular (RV) remodeling in patients with AHF.
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Biophysical and biochemical factors in the cellular microenvironment; effects on cell migration and invasion
… phosphorylation of a lectin binding protein, galectin-3. Upon phosphorylation, galectin-3 is secreted into the ECM from where it is able to modulate traction force and associated events involving focal adhesion maturation and adhesion strength. It however, does not influence mechanosensing. …
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Targeting LGALS3 to treat steatotic liver disease and hepatocarcinogenesis
… potential targets or biomarkers, and among them, Galectin 3 (Gal-3) appears to be one of the most promising. While Gal-3 is not expressed by hepatocytes in the healthy liver, its elevated serum levels have been observed in individuals with steatotic liver disease, non-alcoholic steatohepatitis …
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Analyzing Interactions Between Cells And Extracellular Matrix By Atomic Force Microscopy
… adhesion receptors for ECM, mediate the former, galectins, a family of animal lectins, the latter. In the second chapter of this thesis, the contributions of both receptor families to the interactions of epithelial MDCK cells with ECM proteins are presented. It was found that galectins-3 and 9 …
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Immunohistochemical Markers and Ultrasound Elastography - New Diagnostic Options in the Assessment of Thyroid Nodules // Имунохистохимични маркери и ултразвукова еластография - нови диагностични възможности в уточняването на тиреоидните възли
… е използването на имунохистохимичен панел от Galectin-3, Cytokeratin-19 и HBME1, които се позитивират в различните варианти на папиларния, фоликуларния и анапластичния карцином, както и в лимфни метастази от първичен тиреоиден рак. При съмнение за онкоцитарен тумор към този панел следва да се …
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The Role Of The Sparc Acidic Domain And Egf-Like Module In Glioma Migration, Invasion, And Signaling
… activation and the secretion and processing of galectin-3, a known target of MMPs. To investigate the roles of specific domains, we used a SPARC-GFP fusion protein and deletion mutant constructs of SPARC-GFP with deletions of either the Acidic Domain or EGF-like Module. We confirm our previous …
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